Results 61 to 70 of about 167,623,506 (304)

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Expressions of matrix metalloproteinases 1 and 3 and their tissue inhibitors in the conjunctival tissue and fibroblasts cultured from conjunctivochalasis [PDF]

International Journal of Ophthalmology, 2017
AIM: To investigate the expression of matrix metalloproteinases 1 and 3 (MMP-1 and MMP-3) and their tissue inhibitors of metalloproteinases 1 and 3 (TIMP-1 and TIMP-3) in the conjunctiva of eyes with conjunctivochalasis (CCh).
Min-Hong Xiang, Xing-Ru Zhang, Zhen-Yong Zhang, Qing-Song Li, Han-Min Wang, Zhu-Mei Han, Huan-Ming Zhou, Yuan-Ling Jia, Xing-Xing Chen   +8 more
doaj   +1 more source

Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9

Matrix Biology, 2023
Extracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments.
Sasha Coates-Park, Carolyn Lazaroff, Sadeechya Gurung, Josh Rich, Alexandra Colladay, Maura O'Neill, Georgina S. Butler, Christopher M. Overall, William G. Stetler-Stevenson, David Peeney   +9 more
openaire   +2 more sources

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts [PDF]

, 2016
Introduction Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in
Andrew J Skelton, Todryk, Stephen M., Rowan, Andrew, Skelton, Andrew J., Skelton, Andrew J, Williams, Rachel C., Preshaw, Philip M.; id_orcid, Preshaw, Philip M, Taylor, John, Rowan, Andrew D., Skelton, Andrew, Preshaw, Philip, Taylor, John J, Taylor, John J., Todryk, Stephen, Philip M Preshaw, Todryk, Stephen M, Rachel C Williams, Stephen M Todryk, Williams, Rachel C, Andrew D Rowan, Rowan, Andrew D, John J Taylor   +22 more
core   +2 more sources

Immunohistochemical Expression of Tissue Inhibitor of Metalloproteinase-1 (Timp-1) in Invasive Breast Carcinoma

Biomolecules & Biomedicine, 2009
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a natural inhibitor of matrix metalloproteinas-es (MMPs). Aim of this study was to assess the immunohistochemical expression of TIMP-1 in invasive breast carcinomas, and to examine its association with
Suada Kuskunović, Svjetlana Radović, Mirsad Dorić, Ajna Hukić, Mirsad Babić, Ivana Tomić, Ivan Selak   +6 more
doaj   +1 more source

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1 [PDF]

, 2000
Bachmeier BE, Nerlich AG, Boukamp P, et al. Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1. BIOLOGICAL CHEMISTRY.
Boukamp, P, Tschesche, Harald, Bachmeier, BE, Bachmeier, B. E., Nerlich, A. G., Fink, E., Fritz, H, Fink, E, Fritz, H., Tschesche, H., Lichtinghagen, R., Nerlich, AG, Lichtinghagen, R, Boukamp, P.   +13 more
core   +1 more source

Early Predictive Value of Matrix Metalloproteinase -9 and Tissue inhibitor of Metalloproteinase-1 for Acute Kidney Injury in Burn Patients: A Cohort Study

مجلة كلية الطب
Background: Acute kidney injury is a serious complication of burn injuries. Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 regulate extracellular matrix remodeling, and their dysregulation may contribute to the development of ...
Maytham H. Tarrad, Manal K. Rasheed, Mohammed H. Al-Sodani   +2 more
doaj   +1 more source

Tissue Inhibitor of Metalloproteinase-3 Promotes Schwann Cell Myelination

ASN Neuro, 2017
Tissue inhibitor of metalloproteinase-3 (TIMP-3) inhibits the activities of various metalloproteinases including matrix metalloproteinases and ADAM family proteins.
Jihyun Kim, Anthony Elias, Taeweon Lee, Patrice Maurel, Haesun A. Kim   +4 more
doaj   +1 more source