Results 51 to 60 of about 167,623,506 (304)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival [PDF]

, 2009
Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited.
Braun, Thomas, Besig, Sophie, Baur, Dorothee M., Prinz, Christian, Rad, Roland, Hoefler, Heinz, Höfler, Heinz, Voland, Petra, Perren, Aurel, Langer, Rupert, Voland, P;Besig, S;Rad, R;Braun, T;Baur, DM;Perren, A;Langer, R;Höfler, H;Prinz, C, Voland, Petra;Besig, Sophie;Rad, Roland;Braun, Thomas;Baur, Dorothee M.;Perren, Aurel;Langer, Rupert;Höfler, Heinz;Prinz, Christian   +11 more
core   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in diagnosis of pleural effusion of malignant origin [PDF]

, 2016
OBJECTIVES: The aim of the present study was to evaluate the diagnostic accuracy of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in differentiating benign from malignant exudative pleural effusions.
DI CARLO, ANGELINA, Mario Santini, Marina Di, Domenico, Santini M., Di Domenico M., Antonio Mazzella, FIORELLI, Alfonso, Feola, Antonia, Mazzella A., Feola A., Fiorelli A., Serena Ricci, D'Angelo L., Alfonso Fiorelli, *, Ricci S., Marina Di Domenico, D'ANGELO, Luigi, Mazzella, Antonio, Di Carlo A., Alfonso Fiorelli, Antonia Feola, Angelina Di Carlo, DI DOMENICO, Marina, D’Angelo, Luigi, Luigi D'Angelo, Ricci, Serena, Santini, Mario   +26 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Clinical Investigation of Matrix Metalloproteinases, Tissue Inhibitors of Matrix Metalloproteinases, and Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Complexes and Their Networks in Apical Periodontitis [PDF]

Journal of Endodontics, 2016
This clinical study investigated the levels of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) and respective forms (MMP/TIMP complexes) in apical periodontitis to determine their networks in the development of clinical/radiographic features, thus quantifying the levels of endotoxins (lipopolysaccharides) present in primarily infected ...
Frederico C. Martinho, Flávia F.C. Teixeira, Flávia G.R. Cardoso, Nádia S. Ferreira, Gustavo G. Nascimento, Cláudio A.T. Carvalho, Márcia C. Valera   +6 more
openaire   +3 more sources

Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]

, 2010
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Burkhart, Julia M., Schwarz, Amelie, Christian Ries, Utzschneider, Daniel, Karolina Plaza, Debela, M., Amelie Schwarz, Plaza, Karolina, Beaufort, Nathalie, Creutzburg, Sabine, Ries, C., Schmitt, M., Burkhart, J. M., Beaufort, N., Plaza, K., Ries, Christian, Schwarz, A., Sabine Creutzburg, Mekdes Debela, Creutzburg, S., Schmitt, Manfred, Utzschneider, D., Julia M. Burkhart, Magdolen, Viktor, Debela, Mekdes, Viktor Magdolen, Nathalie Beaufort, Magdolen, V., Beaufort, N;Plaza, K;Utzschneider, D;Schwarz, A;Burkhart, JM;Creutzburg, S;Debela, M;Schmitt, M;Ries, C;Magdolen, V   +28 more
core   +1 more source

MMP-2 and TIMP-2 in patients with heart failure and chronic kidney disease

Open Medicine, 2018
The aim of the study was to assess MMP-2 (matrix metalloproteinase-2) and TIMP-2 (tissue inhibitor of metalloproteinase-2) serum levels in patients with diverse types of heart failure (HF) and chronic kidney disease (CKD).
Kobusiak-Prokopowicz Malgorzata, Krzysztofik Justyna, Kaaz Konrad, Jolda-Mydlowska Beata, Mysiak Andrzej   +4 more
doaj   +1 more source

Association of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels with diabetic foot ulcer in Egyptians with type 2 diabetes mellitus

Journal of Medicine in Scientific Research, 2018
Background The imbalance between matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) may play an important role in impaired healing of diabetic foot ulcer.
Ghada H Sayed, Ghada A Omar, Ayat I Ghanem, Naglaa F Mohamed, Mourad I El-Kholy   +4 more
doaj   +1 more source

Circulating Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Cardiac Amyloidosis [PDF]

Journal of the American Heart Association, 2013
Background Cardiac amyloidosis due to amyloid fibril deposition in the heart results in cardiomyopathy ( CMP ) with heart failure ( HF ) and/or conduction disturbances. Immunoglobulin light chain–related CMP ( AL
Tanaka, Komei, Essick, Eric E., Doros, Gheorghe, Tanriverdi, Kahraman, Connors, Lawreen H., Seldin, David C., Sam, Flora   +6 more
openaire   +2 more sources