Results 131 to 140 of about 122,684 (358)

The Sample Type used Affects the Levels of Gelatinases (MMP-2 and -9) and their Inhibitors (TIMP-1 and -2) in Circulating Blood of Healthy Controls and Breast Cancer Patients

Biomarker Insights, 2007
New potential tumor markers such as matrix metalloproteinases and their inhibitors have been extensively studied during the last decades. The aim is to find prognostic markers that are measurable in easily available samples, such as serum or plasma.
Kuvaja Paula, Talvensaari-Mattila Anne, Turpeenniemi-Hujanen Taina   +2 more
doaj  

Translational augmentation of pro‐matrix metalloproteinase 3 (prostromelysin 1) and tissue inhibitor of metalloproteinases (TIMP)‐1 mRNAs induced by epidermal growth factor in human uterine cervical fibroblasts [PDF]

, 1996
Tetsuji Hosono, Akira Ito, Takashi Sato, Hideaki Nagase, Yo Mori   +4 more
openalex   +1 more source

TL1A/DR3 axis involvement in the inflammatory cytokine network during pulmonary sarcoidosis [PDF]

, 2015
BACKGROUND: TNF-like ligand 1A (TL1A), a recently recognized member of the TNF superfamily, and its death domain receptor 3 (DR3), firstly identified for their relevant role in T lymphocyte homeostasis, are now well-known mediators of several immune ...
A. Cabrelle, A. Teramo, C Agostini, C Agostini, C Agostini, C Agostini, C Agostini, C Agostini, C. Agostini, F Meylan, F. Calabrese, F. Calzetti, F. Cinetto, G Bamias, G Bamias, G Bamias, G Mautino, G. Semenzato, GW Jones, J Müller-Quernheim, KA Oswald-Richter, KL Wallace, KS Lee, L Li, L Nissinen, M Facco, M Facco, M. A. Cassatella, M. Facco, MA Cassatella, MA Judson, MT Henry, N Kamada, N Kamada, N. Tamassia, R Polverosi, RE Vandenbroucke, S. Carraro, SK Bedoya, TH Schreiber, TS Migone, V. Martini, VY Taraban, X Sun, Y Aiba, YJ Kang   +45 more
core   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Genes responsible for vaginal extracellular matrix metabolism are modulated by women's reproductive cycle and menopause

International Brazilian Journal of Urology, 2013
Objectives To analyze the expression of genes involved in extracellular matrix (ECM) biogenesis and remodeling in vaginal tissue of women with clinically normal pelvic floor support (defined as controls) according to the phase of menstrual cycle and ...
Oksana Shynlova, Maria A. T. Bortolini, May Alarab   +2 more
doaj  

Erratum to microRNA-221 promotes proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) by targeting tissue inhibitor of metalloproteinases-3 (TIMP3). [PDF]

Cardiovasc Diagn Ther, 2023
Editorial Office.
europepmc   +1 more source

Localization and Potential Role of Matrix Metalloproteinase-1 and Tissue Inhibitors of Metalloproteinase-1 and -2 in Different Phases of Bronchopulmonary Dysplasia [PDF]

, 2001
Willem A. Dik, Ronald R. de Krijger, Lambert Bonekamp, Brigitta A. E. Naber, Luc J. I. Zimmermann, Marjan A. Versnel   +5 more
openalex   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Evaluation the tissue inhibitor of matrix metalloproteinases first type concentration in various platelet-related products

Российский офтальмологический журнал
Purpose: to evaluate the content of tissue inhibitor of matrix metalloproteinase type 1 (TIMP-1) in platelet preparations obtained in different methods.Material and methods.
E. V. Chentsova, N. V. Borovkova, K. V. Sirotkina, O. V. Beznos, M. S. Makarov, I. N. Ponomarev, M. V. Storozheva   +6 more
doaj   +1 more source