Results 261 to 270 of about 166,094,829 (292)

Tissue Inhibitor of Metalloproteinase Expression

1998
Invasion and metastasis are the most life threatening aspects of the oncogenic process. Present therapies, which focus mainly on disruption of growth and division of tumour cells, are of limited use against most highly malignant solid tumours, as they do not combat the invasive and metastatic characteristics of the tumour cells.
A. M. McElligott, A. H. Baker, H. McGlynn   +2 more
openaire   +1 more source

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in colonic adenomas-adenocarcinomas

Diseases of the Colon & Rectum, 1996
Colonic adenocarcinomas evolve through a multistep process from tubular adenomas to invasive adenocarcinomas. Matrix metalloproteinases (MMPs) have been implicated in proteolysis of basement membrane for initiation of metastatic cascade.By immunocytochemical staining, hyperplastic polyps, tubular adenomas, tubovillous adenomas, villous adenomas to ...
T, Tomita, K, Iwata
openaire   +2 more sources

Acetylation in the regulation of metalloproteinase and tissue inhibitor of metalloproteinases gene expression

Frontiers in Bioscience, 2007
Together, the matrix metalloproteinases (MMPs) are capable of degrading every component of the extracellular matrix (ECM). Besides degradation of the ECM, MMPs release bioactive molecules from the matrix or cell surface and play important role in tissue repair after injury, development and in a number of pathologies including arthritis and cancer ...
Clark IM, Swingler TE, Young DA
openaire   +3 more sources

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis

Cardiovascular Pathology, 2006
Coxsackievirus B3 (CVB3) is the major causative agent of myocarditis in humans. In the mouse model, the inflammatory phase of myocarditis results in extensive damage to the heart and triggers profound extracellular matrix (ECM) remodeling, which may ultimately lead to dilated cardiomyopathy.
Caroline, Cheung, Honglin, Luo, Bobby, Yanagawa, Hon Sing, Leong, Dinesh, Samarasekera, John C K, Lai, Agripina, Suarez, Jingchun, Zhang, Bruce M, McManus   +8 more
openaire   +2 more sources

Secretion of matrix metalloproteinases and their inhibitors (tissue inhibitor of metalloproteinases) by human prostate in explant cultures: reduced tissue inhibitor of metalloproteinase secretion by malignant tissues.

Cancer research, 1993
Unregulated secretion of matrix metalloproteinases (MMPs) or their endogenous protein inhibitors (tissue inhibitor of metalloproteinases, TIMPs) has been implicated in tumor invasion and metastasis. Species of MMPs and TIMPs secreted by epithelial cultures of normal, benign, and malignant prostate were identified and their levels were compared ...
B L, Lokeshwar, M G, Selzer, N L, Block, Z, Gunja-Smith   +3 more
openaire   +1 more source

Tissue Inhibitors of Metalloproteinases in Cancer

2002
Our understanding of the biological function of tissue inhibitors of metalloproteinases (TIMP) has significantly evolved from an initial focus on the extracellular matrix (ECM) to a much broader function that includes a regulatory role on cell growth, survival and transformation. The bases for this larger role of TIMPs are several. 1.
openaire   +1 more source

Tissue Inhibitors of Metalloproteinases

2008
Liliana Guedez, Enrique Zudaire, William G. Stetler-Stevenson   +2 more
openaire   +1 more source

Tissue Inhibitor of Metalloproteinase

2017
Marcello G. Masciantonio, Sean E. Gill
openaire   +1 more source

TISSUE INHIBITOR OF METALLOPROTEINASES

1986
T. E. Cawston, E. Mercer, C. Mooney, J. K. Wright   +3 more
openaire   +1 more source

Lack of Tissue Inhibitor of Metalloproteinases 2 Leads to Exacerbated Left Ventricular Dysfunction and Adverse Extracellular Matrix Remodeling in Response to Biomechanical Stress

Circulation, 2011
Dong Fan, Zamaneh Kassiri
exaly