Results 1 to 10 of about 59,510 (161)

Role of Matrix Metalloproteinases and Tissue Inhibitors in Sepsis Pathogenesis [PDF]

Medical Sciences
Background: This study investigates the role of MMPs and TIMPs in sepsis pathogenesis. We aim to assess multiple potential biomarkers including MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, TIMP-1, TIMP-2, TIMP-3 in serum, brain and kidney tissue samples ...
Rasime Sevgi Cenan, Ayşegül Karaoğlan, Hatice Paşaoğlu   +2 more
doaj   +2 more sources

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Echinoderms: Structure and Possible Functions

Cells, 2021
Echinoderms are one of the most ancient groups of invertebrates. The study of their genomes has made it possible to conclude that these animals have a wide variety of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs ...
Igor Yu. Dolmatov, Vladimir A. Nizhnichenko, Lyudmila S. Dolmatova   +2 more
doaj   +3 more sources

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases [PDF]

Circulation Research, 2003
Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration.
Hideaki Nagase, Robert Visse
exaly   +3 more sources

MATRIX METALLOPROTEINASES AND TISSUE INHIBITORS OF MATRIX METALLOPROTEINASES DURING PREGNANCY AND DELIVERY

Acta Biomedica Scientifica, 2012
Matrix metalloproteinases are main proteolytic enzymes breaking down most components of extracellular matrix of various tissues. In the review shows role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases during implantation,
Yu. V. Korenovsky, L. M. Sinelnikova, O. N. Filchakova, Yu. V. Shabalina, Ye. G. Yershova, N. I. Fadeyeva, S. A. Yelchaninova   +6 more
doaj   +1 more source

Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases Ratio: A Biomarker of Bone Resorption in Geriatric Osteoporosis? [PDF]

Annals of Geriatric Medicine and Research, 2023
Background Matrix metalloproteinases (MMPs) play an important role in bone resorption and are regulated by tissue inhibitors of metalloproteinases (TIMPs).
Bahar Bektan Kanat, Gulru Ulugerger Avci, Osman Faruk Bayramlar, Damla Unal, Ozge Sonmez, Ibrahim Murat Bolayirli, Alper Doventas, Deniz Suna Erdincler, Hakan Yavuzer   +8 more
doaj   +1 more source

Clinical Investigation of Matrix Metalloproteinases, Tissue Inhibitors of Matrix Metalloproteinases, and Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Complexes and Their Networks in Apical Periodontitis [PDF]

Journal of Endodontics, 2016
This clinical study investigated the levels of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) and respective forms (MMP/TIMP complexes) in apical periodontitis to determine their networks in the development of clinical/radiographic features, thus quantifying the levels of endotoxins (lipopolysaccharides) present in primarily infected ...
Frederico C. Martinho, Flávia F.C. Teixeira, Flávia G.R. Cardoso, Nádia S. Ferreira, Gustavo G. Nascimento, Cláudio A.T. Carvalho, Márcia C. Valera   +6 more
openaire   +3 more sources

The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study

BMC Research Notes, 2021
Objective Matrix metalloproteinases (MMPs) are important regulators of vascular and uterine remodeling. They exhibit proteolytic activity implicating the efficiency of trophoblast invasion to the uterine wall involving marked hemodynamic and uterine ...
Ritva Nissi, Markku Santala, Anne Talvensaari-Mattila   +2 more
doaj   +1 more source

Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention

Frontiers in Physiology, 2021
Systemic sclerosis (SSc) is a chronic debilitating idiopathic disorder, characterized by deposition of excessive extracellular matrix (ECM) proteins such as collagen which leads to fibrosis of the skin and other internal organs.
Edwin Leong, Michael Bezuhly, Michael Bezuhly, Jean S. Marshall, Jean S. Marshall   +4 more
doaj   +1 more source

Features of the level of matrix metalloproteinase-2, -3, -9 and tissue inhibitors of metalloproteinases-1, -2, -3, -4 in the aqueous humor of patients with primary open-angle glaucoma

Бюллетень сибирской медицины, 2022
Aim. To study the content of matrix metalloproteinase (MMP)-2, -3, -9 and tissue inhibitors of metalloproteinases (TIMPs) -1, -2, -3, -4 in the aqueous humor of patients with moderate primary open-angle glaucoma (POAG).Materials and methods.
V. V. Chernykh, V. I. Konenkov, O. V. Ermakova, N. B. Orlov, A. N. Trunov   +4 more
doaj   +1 more source

Content of matrix metalloproteinases in the blood of hypertensive patients with a high cardiovascular risk receiving statin therapy

Кардиоваскулярная терапия и профилактика, 2022
Aim. To compare the effect of atorvastatin and rosuvastatin as part of complex therapy in patients with hypertension (HTN) with a high cardiovascular risk on the level of matrix metalloproteinases -1, -9 (MMP-1, MMP-9) and tissue inhibitors of ...
V. P. Mikhin, O. A. Osipova, V. V. Vorotyntseva, D. N. Perutsky, N. I. Golovina   +4 more
doaj   +1 more source