Results 1 to 10 of about 100,799 (312)

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases [PDF]

Circulation Research, 2003
Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration.
Visse, R, Nagase, H
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MATRIX METALLOPROTEINASES AND TISSUE INHIBITORS OF MATRIX METALLOPROTEINASES DURING PREGNANCY AND DELIVERY

Acta Biomedica Scientifica, 2012
Matrix metalloproteinases are main proteolytic enzymes breaking down most components of extracellular matrix of various tissues. In the review shows role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases during implantation,
Yu. V. Korenovsky, L. M. Sinelnikova, O. N. Filchakova, Yu. V. Shabalina, Ye. G. Yershova, N. I. Fadeyeva, S. A. Yelchaninova   +6 more
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Analysis of the Role of Gene Variants in Matrix Metalloproteinases and Their Tissue Inhibitors in Bronchopulmonary Dysplasia (BPD): A Study in the Polish Population [PDF]

Current Issues in Molecular Biology
This study aimed to explore the association between genetic variants of matrix metalloproteinases (MMP-1 rs1799750, MMP-9 rs17576, and rs17577) and their tissue inhibitors (TIMP-1 rs4898, TIMP-2 rs2277698, and rs55743137) in the development of ...
Dawid Szpecht, Kareem Abu-Amara, Grażyna Kurzawinska, Agnieszka Seremak-Mrozikiewicz   +3 more
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Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases Ratio: A Biomarker of Bone Resorption in Geriatric Osteoporosis? [PDF]

Annals of Geriatric Medicine and Research, 2023
Background Matrix metalloproteinases (MMPs) play an important role in bone resorption and are regulated by tissue inhibitors of metalloproteinases (TIMPs).
Bahar Bektan Kanat, Gulru Ulugerger Avci, Osman Faruk Bayramlar, Damla Unal, Ozge Sonmez, Ibrahim Murat Bolayirli, Alper Doventas, Deniz Suna Erdincler, Hakan Yavuzer   +8 more
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Clinical Investigation of Matrix Metalloproteinases, Tissue Inhibitors of Matrix Metalloproteinases, and Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Complexes and Their Networks in Apical Periodontitis [PDF]

Journal of Endodontics, 2016
This clinical study investigated the levels of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) and respective forms (MMP/TIMP complexes) in apical periodontitis to determine their networks in the development of clinical/radiographic features, thus quantifying the levels of endotoxins (lipopolysaccharides) present in primarily infected ...
Frederico C. Martinho, Flávia F.C. Teixeira, Flávia G.R. Cardoso, Nádia S. Ferreira, Gustavo G. Nascimento, Cláudio A.T. Carvalho, Márcia C. Valera   +6 more
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Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention

Frontiers in Physiology, 2021
Systemic sclerosis (SSc) is a chronic debilitating idiopathic disorder, characterized by deposition of excessive extracellular matrix (ECM) proteins such as collagen which leads to fibrosis of the skin and other internal organs.
Edwin Leong, Michael Bezuhly, Michael Bezuhly, Jean S. Marshall, Jean S. Marshall   +4 more
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The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study

BMC Research Notes, 2021
Objective Matrix metalloproteinases (MMPs) are important regulators of vascular and uterine remodeling. They exhibit proteolytic activity implicating the efficiency of trophoblast invasion to the uterine wall involving marked hemodynamic and uterine ...
Ritva Nissi, Markku Santala, Anne Talvensaari-Mattila   +2 more
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Engineered Sarafotoxins as Tissue Inhibitor of Metalloproteinases-like Matrix Metalloproteinase Inhibitors [PDF]

Journal of Biological Chemistry, 2007
The sarafotoxins and endothelins are approximately 25-residue peptides that spontaneously fold into a defined tertiary structure with specific pairing of four cysteines into two disulfide bonds. Their structures show an interesting topological similarity to the core of the metalloproteinase interaction sites of the tissue inhibitors of ...
Janelle L, Lauer-Fields, Mare, Cudic, Shuo, Wei, Frank, Mari, Gregg B, Fields, Keith, Brew   +5 more
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Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Echinoderms: Structure and Possible Functions

Cells, 2021
Echinoderms are one of the most ancient groups of invertebrates. The study of their genomes has made it possible to conclude that these animals have a wide variety of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs ...
Igor Yu. Dolmatov, Vladimir A. Nizhnichenko, Lyudmila S. Dolmatova   +2 more
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Tissue Inhibitor of Metalloproteinase-1: Actions beyond Matrix Metalloproteinase Inhibition [PDF]

Cardiology, 2015
Matrix metalloproteinases (MMPs) are a family of zinc-dependent enzymes, which include 25 current members. MMPs degrade structural components of extracellular matrix and process bioactive molecules including cytokines, chemokines, and growth factors [1].
Merry L. Lindsey, Andriy Yabluchanskiy, Yonggang Ma   +2 more
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