Results 21 to 30 of about 166,146,473 (295)

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

Activity of matrix metalloproteinases and their tissue inhibitors in serum in chronic granulating periodontitis

Patologìâ, 2019
Aim. The aim of the work is to study the activity of matrix metalloproteinases and their tissue inhibitors in chronic granular periodontitis. Materials and methods. We examined serum of 15 patients with chronic granulating periodontitis and 15 healthy
D. I. Haidash, I. S. Haidash, O. О. Bondar, Yu. О. Yevtushenko, O. I. Haidash   +4 more
doaj   +1 more source

Role of matrix metalloproteinases in diabetic foot ulcers: Potential therapeutic targets

Frontiers in Pharmacology, 2022
Diabetic foot ulcers (DFUs) are pathological states of tissue destruction of the foot or lower extremity in diabetic patients and are one of the serious chronic complications of diabetes mellitus.
Kang Fu, Xueyao Zheng, Yuhan Chen, Yuhan Chen, Liuying Wu, Liuying Wu, Zhiming Yang, Zhiming Yang, Xu Chen, Xu Chen, Wei Song, Wei Song   +11 more
doaj   +1 more source

Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]

, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Kolev, Kraszimir, Kolev Krasimir, Rottenberger Zsolt, Zsolt Rottenberger, Rottenberger, Zsolt, Krasimir Kolev   +5 more
core   +1 more source

The relationship between the first episode of wheezing and matrix metalloproteinases-9 and MMP-2 and tissue inhibitors of MMP-1 levels in preterm infants

Annals of Thoracic Medicine, 2013
Aims: Matrix metalloproteinases (MMP) have been associated with neonatal lung morbidity and MMP dysregulation contributes to the pathology of chronic and acute lung disorders.
Rabia Gonul Sezer, Gokhan Aydemir, Abdulkadir Bozaykut, Serdar Hira, Ilhan Asya Tanju, Ömer Özcan   +5 more
doaj   +1 more source

Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9

Matrix Biology, 2023
Extracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments.
Sasha Coates-Park, Carolyn Lazaroff, Sadeechya Gurung, Josh Rich, Alexandra Colladay, Maura O'Neill, Georgina S. Butler, Christopher M. Overall, William G. Stetler-Stevenson, David Peeney   +9 more
openaire   +2 more sources

Circulating Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Cardiac Amyloidosis [PDF]

Journal of the American Heart Association, 2013
Background Cardiac amyloidosis due to amyloid fibril deposition in the heart results in cardiomyopathy ( CMP ) with heart failure ( HF ) and/or conduction disturbances. Immunoglobulin light chain–related CMP ( AL
Tanaka, Komei, Essick, Eric E., Doros, Gheorghe, Tanriverdi, Kahraman, Connors, Lawreen H., Seldin, David C., Sam, Flora   +6 more
openaire   +2 more sources

Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma

World Journal of Surgical Oncology, 2013
Background Matrix metalloproteinases (MMPs) are one of the major classes of proteolytic enzymes involved in tumor invasion and metastasis and are inhibited by naturally occurring tissue inhibitors of metalloproteinases (TIMPs).
Qiao Zhen-kui, Li Yan-long, Lu Hong-tao, Wang Ke-liang, Xu Wan-hai   +4 more
doaj   +1 more source

MMPs and TIMPs expression in facial tissue of children with cleft lip and palate

Biomedical Papers, 2016
Background and Aims: Morphogenesis of the upper lip and palate is a complex process involving highly regulated interactions between epithelial and mesenchymal cells.
Liene Smane-Filipova, Mara Pilmane, Ilze Akota   +2 more
doaj   +1 more source

Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle

Experimental and Therapeutic Medicine, 2016
According to the growth state of hair follicles, the hair cycle is divided into the anagen, catagen and telogen phases. A number of biological factors have been shown to synchronize with the hair cycle. As an important component of the hair follicle, the extracellular matrix is regulated by matrix metalloproteinases (MMPs) and their inhibitors (tissue ...
HOU, CHUN, MIAO, YONG, WANG, XUE, CHEN, CHAOYUE, LIN, BOJIE, HU, ZHIQI   +5 more
openaire   +3 more sources