Scientific Reports, 2021 Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients.
Yu Zuo +9 more
doaj +2 more sources
In acute ischemic stroke patients with smoking incidence, are more women than men more likely to be included or excluded from thrombolysis therapy? [PDF]
Women's Health, 2020 Background: Clinical factors associated with exclusion from recombinant tissue plasminogen activator in both men and women are not completely understood.
Oluyemi R Rotimi +5 more
doaj +3 more sources
JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells [PDF]
Journal of Biomedical Science, 2011 Background Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular
Chen Wei-Kung +9 more
doaj +5 more sources
Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors [PDF]
Frontiers in Pharmacology, 2021 Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the ...
María D. Valls +14 more
doaj +3 more sources
Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines [PDF]
Journal of Neuroinflammation, 2019 Background Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune system stimulants.
Paola Pontecorvi +8 more
doaj +3 more sources
Incidence of Hemorrhagic Complications among Patients Treated with Thrombolytic in Erbil City, Iraq [PDF]
Al-Anbar Medical Journal, 2020 Background: Recombinant tissue-type plasminogen activator is an option of treatment for suspected occlusive vascular thrombi and its sequel (transmural myocardial infarction, pulmonary embolism, and ischemic stroke). The most important concern associated
Ahmed F. Hammad +2 more
doaj +1 more source
The Role of Fibrinolytic System in Health and Disease [PDF]
, 2022 This is a review of the topic of fibrinolysis contributed by authors who are specialized in the clinical and basic studies of this topic. These include: the endothelial receptor of tissue plasminogen activator, by Dr. Katherine Hajjar; regulation of S100
core +1 more source
Histone deacetylase inhibitor treatment increases coronary t-PA release in a porcine ischemia model. [PDF]
PLoS ONE, 2014 BACKGROUND: The expression of the tissue plasminogen activator gene can be affected by histone deacetylation inhibition and thus appears to be under epigenetic control.
Kristina Svennerholm +6 more
doaj +1 more source
Tissue plasminogen activator for acute ischemic stroke.
New England Journal of Medicine, 1996 BACKGROUND Thrombolytic therapy for acute ischemic stroke has been approached cautiously because there were high rates of intracerebral hemorrhage in early clinical trials.
Koroshetz Wj
semanticscholar +2 more sources
Journal of Thrombosis and Haemostasis, 2020 A prothrombotic coagulopathy is commonly found in critically ill COVID‐19 patients with acute respiratory distress syndrome (ARDS). A unique feature of COVID‐19 respiratory failure is a relatively preserved lung compliance and high Alveolar‐arterial ...
Janice Wang +8 more
semanticscholar +1 more source