Results 11 to 20 of about 160,265 (347)

Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface [PDF]

The Ukrainian Biochemical Journal, 2019
Platelets play a key role in hemostasis as cofactors of thrombin generation, fibrin polymerization centers­, and initiators of clot retraction, while their ability to modulate clot dissolution remains less understood.
T. Grinenko, О. Yusova, O. Revka, I. Patalakh, T. Yatsenko   +4 more
doaj   +1 more source

Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies [PDF]

Neuroscience, 2010
A growing body of evidence demonstrates the involvement of plasminogen activators (PAs) in a number of physiologic and pathologic events in the CNS. Induction of both tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) has been observed in different experimental models of epilepsy and tPA has been implicated in the mechanisms ...
A. M. Iyer, E. Zurolo, K. Boer, J. C. Baayen, GIANGASPERO, FELICE, A. Arcella, G. C. Di Gennaro, ESPOSITO, Vincenzo, W. G. M. Spliet, P. C. Van Rijen, D. Troost, J. A. Gorter, E. Aronica   +12 more
openaire   +8 more sources

Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury after traumatic brain injury

Neural Regeneration Research, 2020
Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported.
Jun-Jie Zhao, Zun-Wei Liu, Bo Wang, Ting-Qin Huang, Dan Guo, Yong-Lin Zhao, Jin-Ning Song   +6 more
doaj   +1 more source

Tissue Plasminogen Activator in Psoriasis

Journal of Investigative Dermatology, 1990
Elevated levels of the serine proteinase plasminogen activator are observed in psoriatic lesions. In contrast to normal epidermis, lesional psoriatic epidermis contains primarily tissue type plasminogen activator (tPA) activity and much lower levels of urokinase type plasminogen activator (uPA) activity.
Gerald S. Lazarus, Nathalie Busso, Pamela J. Jensen, Dominique Belin, Dominique Belin, Pascale Gubler, Jean-Dominique Vassalli, Janet Baird   +7 more
openaire   +4 more sources

The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays.

PLoS ONE, 2017
Due to controversial evidence in the literature pertaining to the activity of plasminogen activator inhibitor-1 in platelets, we examined the effects of residual platelets present in plasma (a potential pre-analytical variable) on various plasminogen ...
Marlien Pieters, Sunelle A Barnard, Du Toit Loots, Dingeman C Rijken   +3 more
doaj   +1 more source

In acute ischemic stroke patients with smoking incidence, are more women than men more likely to be included or excluded from thrombolysis therapy?

Women's Health, 2020
Background: Clinical factors associated with exclusion from recombinant tissue plasminogen activator in both men and women are not completely understood.
Oluyemi R Rotimi, Iretioluwa F Ajani, Alexandria Penwell, Shyyon Lari, Brittany Walker, Thomas I Nathaniel   +5 more
doaj   +1 more source

Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II trials [PDF]

, 2009
<p><b>Background and Purpose:</b> A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies.</p> <p><b>Methods:</b> We examined patients with
Cucchiara, B., Demchuk, A., Kasner, S.E., Lees, K.R., Levine, S.R., Lyden, P., Messe, S.R., Sansing, L., Tanne, D.   +8 more
core   +1 more source

Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis

Haematologica, 2012
Background We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation.Design and Methods Circulating microparticles ...
Romaric Lacroix, Laurent Plawinski, Stéphane Robert, Loïc Doeuvre, Florence Sabatier, Sara Martinez de Lizarrondo, Anna Mezzapesa, Francine Anfosso, Aurelie S. Leroyer, Pascale Poullin, Noémie Jourde, Makon-Sébastien Njock, Chantal M. Boulanger, Eduardo Anglés-Cano, Françoise Dignat-George   +14 more
doaj   +1 more source

Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Frontiers in Pharmacology, 2021
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the ...
María D. Valls, María Soldado, Jorge Arasa, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, Bruce N. Cronstein, Bruce N. Cronstein, M. Antonia Noguera, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Terencio, M. Carmen Montesinos, M. Carmen Montesinos   +14 more
doaj   +1 more source

Spectrophotometric analysis of thrombolytic activity: SATA assay [PDF]

, 2017
Introduction: Measurement of thrombolytic activity i.e. clot lysis is crucial for research and development of novel thrombolytics. It is also a key factor in assessment of the effectiveness of conventionally used thrombolytic agents in the clinic, which ...
Entekhabi, Nazila, Eskandani, Morteza, Farhoudi, Mehdi, Mohammadian, Reza, Rafi, Mohammad, Zamanlu, Masumeh   +5 more
core   +2 more sources