Results 11 to 20 of about 83,548 (314)

Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury after traumatic brain injury

Neural Regeneration Research, 2020
Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported.
Jun-Jie Zhao, Zun-Wei Liu, Bo Wang, Ting-Qin Huang, Dan Guo, Yong-Lin Zhao, Jin-Ning Song   +6 more
doaj   +1 more source

Tissue Plasminogen Activator in Psoriasis

Journal of Investigative Dermatology, 1990
Elevated levels of the serine proteinase plasminogen activator are observed in psoriatic lesions. In contrast to normal epidermis, lesional psoriatic epidermis contains primarily tissue type plasminogen activator (tPA) activity and much lower levels of urokinase type plasminogen activator (uPA) activity.
Gerald S. Lazarus, Nathalie Busso, Pamela J. Jensen, Dominique Belin, Dominique Belin, Pascale Gubler, Jean-Dominique Vassalli, Janet Baird   +7 more
openaire   +4 more sources

The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays.

PLoS ONE, 2017
Due to controversial evidence in the literature pertaining to the activity of plasminogen activator inhibitor-1 in platelets, we examined the effects of residual platelets present in plasma (a potential pre-analytical variable) on various plasminogen ...
Marlien Pieters, Sunelle A Barnard, Du Toit Loots, Dingeman C Rijken   +3 more
doaj   +1 more source

In acute ischemic stroke patients with smoking incidence, are more women than men more likely to be included or excluded from thrombolysis therapy?

Women's Health, 2020
Background: Clinical factors associated with exclusion from recombinant tissue plasminogen activator in both men and women are not completely understood.
Oluyemi R Rotimi, Iretioluwa F Ajani, Alexandria Penwell, Shyyon Lari, Brittany Walker, Thomas I Nathaniel   +5 more
doaj   +1 more source

Tissue plasminogen activator mRNA in murine tissues [PDF]

FEBS Letters, 1988
The urokinase‐type and tissue‐type plasminogen activators are the two enzymes found in mammals, which specifically convert the zymogen plasminogen to plasmin. Using cDNA probes, we have assayed for the presence of the two types of plasminogen activator mRNAs in murine tissues.
Richard J. Rickles, Sidney Strickland
openaire   +3 more sources

Successful Treatment of Arterial Thrombus in an Extremely Low-Birth-Weight Preterm Neonate

Pediatrics and Neonatology, 2013
Arterial thromboembolism in the pediatric population frequently occurs secondary to arterial catheterization. Catheterization-related complications are more common in smaller and sicker infants, due to high prothrombotic activity, low levels of natural ...
Petek G. Kayıran, Berkan Gürakan, Sinan M. Kayıran   +2 more
doaj   +1 more source

Tissue plasminogen activator for dysfunctional tunneled vascular catheters for hemodialysis - single center experience [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Introduction/Objective. Thrombosis of hemodialysis catheters is one of the major complications, which leads to catheter dysfunction. Although tissue plasminogen activator has been proven to be effective in reestablishing blood flow rate through ...
Todorov Verica, Janković Aleksandar, Đurić Petar, Bulatović Ana, Popović Jovan, Dimković Nada   +5 more
doaj   +1 more source

Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis

Haematologica, 2012
Background We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation.Design and Methods Circulating microparticles ...
Romaric Lacroix, Laurent Plawinski, Stéphane Robert, Loïc Doeuvre, Florence Sabatier, Sara Martinez de Lizarrondo, Anna Mezzapesa, Francine Anfosso, Aurelie S. Leroyer, Pascale Poullin, Noémie Jourde, Makon-Sébastien Njock, Chantal M. Boulanger, Eduardo Anglés-Cano, Françoise Dignat-George   +14 more
doaj   +1 more source

Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Frontiers in Pharmacology, 2021
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the ...
María D. Valls, María Soldado, Jorge Arasa, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, Bruce N. Cronstein, Bruce N. Cronstein, M. Antonia Noguera, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Terencio, M. Carmen Montesinos, M. Carmen Montesinos   +14 more
doaj   +1 more source

Intravenous tissue plasminogen activator for ischemic stroke in early pregnancy dosed by actual body weight

SAGE Open Medical Case Reports, 2019
Introduction: Few published reports highlight intravenous tissue plasminogen activator use during the first trimester of pregnancy and provide outcomes for mother and fetus.
Gary D Peksa, Jamie Ostrem, Teresa Davis
doaj   +1 more source