Results 231 to 240 of about 162,477 (300)

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source

Intrapleural tissue plasminogen activator and deoxyribonuclease in complex pleural effusion and empyema, clinical outcomes, and predictors. [PDF]

Ther Adv Respir Dis
Sedhai YR, Bhat P, Acharya R, Qureshi NQ, Mohammed F, Waheed I, Khan TMA, Ahmed MA, Kazimuddin N, Kafle A, Steff RT, Singh K.   +11 more
europepmc   +1 more source

Adjunctive Thrombolytics After Successful Endovascular Reperfusion: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Annals of Neurology, Volume 98, Issue 6, Page 1299-1314, December 2025.
Objective The efficacy and safety of intra‐arterial thrombolysis (IAT) as an adjunct to endovascular thrombectomy (EVT) in large vessel occlusion strokes (LVOS) remain uncertain, with recent randomized controlled trials (RCTs) yielding conflicting results.
Mohamed F. Doheim, Mahmoud H. Mohammaden, Ammar Jumah, Qingwu Yang, Wenjie Zi, Yangmei Chen, Yamei Tang, Yajie Liu, Xiaochuan Huo, Liping Liu, Bernard Yan, Zhongrong Miao, Wei Hu, Chunrong Tao, Xinfeng Liu, Liqun Jiao, Xuesong Bai, Wenhuo Chen, Diogo C. Haussen, Thanh Nguyen, Raul G. Nogueira   +20 more
wiley   +1 more source

Correction: Usefulness of carotid duplex ultrasonography in predicting residual large-vessel occlusions after intravenous recombinant tissue plasminogen activator therapy in patients with acute ischemic stroke. [PDF]

J Med Ultrason (2001)
Kaburagi K, Shimizu T, Hagiwara Y, Fukano T, Shibata S, Hoshino M, Sasaki N, Akiyama H, Hasegawa Y, Yamano Y.   +9 more
europepmc   +1 more source

Iron enhances reactive oxygen species generation and initiates neutrophil extracellular traps formation on the endothelium to exacerbate stroke

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Under hypoxic conditions, iron from red blood cells and injured tissues is taken up by endothelial cells. During reoxygenation, this iron is exported via Fpn1, promoting NETs formation by enhancing ROS production through the Fenton reaction, ultimately exacerbating cerebral injury.
Weijian Fan, Zebin Fang, Yuxiang Weng, Tianxiang Zhan, Kaiyuan Huang, Jianwei Pan, Renya Zhan   +6 more
wiley   +1 more source

DL‐3‐n‐Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing GCN5L1‐Mediated Drp1 Acetylation in Neurons and Mouse Brains

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
This study provides a novel insight into the molecular mechanism whereby NBP protects mitochondria against ischemia/hypoxia damage, offering a promising drug for mitochondria‐targeting therapeutics for ischemic stroke. ABSTRACT Background Mitochondrial dysfunction is an initial event of the cascade reactions triggered by ischemic stroke, contributing ...
Haitao Zhang, Ning Zhang, Xiaotong Yang, Jiejie Zhang, Xiaoli Ge, Lei Wang, Shan Wang, Ya Wen   +7 more
wiley   +1 more source

Tissue plasminogen activator associated pulmonary hemorrhage in patient with ACTA2-associated arteriopathy. [PDF]

J Vasc Surg Cases Innov Tech
Hughes TG, Wurth MA, Sheppard MB.
europepmc   +1 more source

Disrupting BMP/TGF‐β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Evaluation of targeted gene silencing and exogenous BMP9 administration in HPMECs. AQP1 silencing decreased TGFB1, TGFBR1, and BMPR2 expression, while BMP9 administration returned TGFB1 to basal levels. TGFB1 silencing upregulated BMP9, while downregulating BMP10 and BMPR2 expression. BMP9 administration downregulated AQP1 expression.
Chrysi Keskinidou, Nikolaos S. Lotsios, Kostas A. Papavassiliou, Athanasios G. Papavassiliou, Ioanna Dimopoulou, Anastasia Kotanidou, David Langleben, Stylianos E. Orfanos, Alice G. Vassiliou   +8 more
wiley   +1 more source

Plasma tissue plasminogen activator-inhibitor complex levels in acute myocardial infarction patients: an observational study. [PDF]

BMC Cardiovasc Disord
Feng YF, Su MY, Xu HX, Zhang SZ, Ma YF, Chen HP.   +5 more
europepmc   +1 more source

Organ Crosstalk During Injury: Mechanisms of Lung–Kidney Interaction in Critical Illness

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Crosstalk between the lungs and kidneys may propagate multiorgan injury in critically ill patients. This review examines evidence of crosstalk between the lungs and kidneys after injury, focusing on translational and mechanistic studies. Pathophysiology and animal models of acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS) are ...
Kathryn M. Sullivan, Kathleen D. Liu, Michael A. Matthay   +2 more
wiley   +1 more source