Results 31 to 40 of about 4,698,204 (249)

Transplantation of Umbilical Cord-Derived Mesenchymal Stem Cells Attenuates Surgical Wound-Induced Blood-Brain Barrier Dysfunction in Mice

Stem Cells International, 2023
Blood-brain barrier (BBB) is the most important component of central nervous system (CNS) to keep toxins and pathogens from CNS. Although our studies demonstrated that using interleukin-6 antibodies (IL-6-AB) reversed the increased permeability of BBB ...
Jie Yang, Hongyu Li, Mingzi Ran, Shuxu Yang, Kui Ma, Cuiping Zhang, Minglu Xiao, Yuguang Yang, Xiaobing Fu, Siming Yang   +9 more
doaj   +1 more source

Study of the inflammatory activating process in the early stage of Fusobacterium nucleatum infected PDLSCs

International Journal of Oral Science, 2023
Fusobacterium nucleatum (F. nucleatum) is an early pathogenic colonizer in periodontitis, but the host response to infection with this pathogen remains unclear. In this study, we built an F. nucleatum infectious model with human periodontal ligament stem
Yushang Wang, Lihua Wang, Tianyong Sun, Song Shen, Zixuan Li, Xiaomei Ma, Xiufeng Gu, Xiumei Zhang, Ai Peng, Xin Xu, Qiang Feng   +10 more
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Force-Induced Nitric Oxide Promotes Osteogenic Activity during Orthodontic Tooth Movement in Mice

Stem Cells International, 2022
Objectives. The aim of this study was to investigate the effect of nitric oxide (NO) on orthodontic tooth movement and the regulatory effect on bone formation. Design.
Yuqing Sun, Jingfei Fu, Feiran Lin, Shengnan Li, Juan Du, Yi Liu, Yuxing Bai   +6 more
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Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway

Frontiers in Oncology, 2020
The treatment of melanoma has remained a difficult challenge. Targeting the tumor stroma has recently attracted attention for developing novel strategies for melanoma therapy.
Tingjian Zu, Tingjian Zu, Jie Wen, Jie Wen, Lin Xu, Lin Xu, Lin Xu, Hui Li, Jun Mi, Jun Mi, Hui Li, Cord Brakebusch, David E. Fisher, Xunwei Wu, Xunwei Wu, Xunwei Wu   +15 more
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A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells

Cell Death and Disease, 2021
p53, the major tumor suppressor, is frequently mutated in many cancers, and up to 84% of human melanomas harbor wild-type p53, which is considered to be an ideal target for melanoma therapy.
Jie Wen, Wenqian Chen, Baoxiang Zhao, Qiuping Xu, Chang Liu, Qun Zhang, Zhiwei Xie, Yonggan Yan, Jing Guo, Jun Huang, Junying Miao, Xunwei Wu   +11 more
doaj   +1 more source

Effects of ERK/p38 MAPKs signaling pathways on MTA-mediated osteo/odontogenic differentiation of stem cells from apical papilla: a vitro study

BMC Oral Health, 2020
Background Stem cells from apical papilla (SCAP) located in the root apex of immature permanent teeth are a reliable cell source for pulp-dentine complex regeneration.
Jing Du, Yating Lu, Mengxiao Song, Lin Yang, Junqing Liu, Xinyu Chen, Yue Ma, Yan Wang   +7 more
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Genipin and insulin combined treatment improves implant osseointegration in type 2 diabetic rats

Journal of Orthopaedic Surgery and Research, 2021
Background Type 2 diabetes mellitus (T2DM) has a harmful effect on the stability and osseointegration of dental implants. T2DM induces mitochondrial damage by inhibiting AMPK signaling, resulting in oxidative stress and poor osteogenesis in the peri ...
Jiajia Zhang, Ya-nan Wang, Tingting Jia, Haiyun Huang, Dongjiao Zhang, Xin Xu   +5 more
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Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes

Frontiers in Cell and Developmental Biology, 2021
Mutations of H-Ras, a member of the RAS family, are preferentially found in cutaneous squamous cell carcinomas (SCCs). H-Ras has been reported to induce autophagy, which plays an essential role in tissue homeostasis in multiple types of cancer cells and ...
Shuangshuang Wang, Hua Qian, Liwei Zhang, Panpan Liu, Panpan Liu, Dexuan Zhuang, Qun Zhang, Fuxiang Bai, Zhihong Wang, Yonggan Yan, Jing Guo, Jing Guo, Jun Huang, Xunwei Wu, Xunwei Wu   +14 more
doaj   +1 more source

Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems

Stem Cell Research & Therapy, 2019
Background Billions of dollars are invested annually by pharmaceutical companies in search of new options for treating hair loss conditions; nevertheless, the challenge remains.
Yiqun Su, Jie Wen, Junrong Zhu, Zhiwei Xie, Chang Liu, Chuan Ma, Qun Zhang, Xin Xu, Xunwei Wu   +8 more
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High-fat and high-glucose microenvironment decreases Runx2 and TAZ expression and inhibits bone regeneration in the mouse

Journal of Orthopaedic Surgery and Research, 2019
Background Type 2 diabetes mellitus (T2DM) and hyperlipidemia are negatively related to bone regeneration. The aim of this study was to evaluate the effect of high-fat and high-glucose microenvironment on bone regeneration and to detect the expression of
Xuan Wu, Yunpeng Zhang, Yixiao Xing, Bin Zhao, Cong Zhou, Yong Wen, Xin Xu   +6 more
doaj   +1 more source