Results 121 to 130 of about 17,677,818 (279)

Regulation of T cell tissue residency and activation in human PCLS

Respiratory Research
Background Resident immune cells are central in shaping the lung’s tissue-specific immunity. Precision-cut lung slices (PCLS) preserve the native tissue microenvironment and are therefore an excellent ex vivo model to analyze residency and functionality ...
Tonia Bargmann, Charline Sommer, Lena Stowasser, Sophie Jacob, Louisa Jürgen, Sebastian Konzok, Christopher Werlein, Patrick Zardo, Lavinia Neubert, Danny Jonigk, Hans-Gerd Fieguth, Franziska Dahlmann, Katherina Sewald, Susann Dehmel, Armin Braun   +14 more
doaj   +1 more source

Location versus ID: what matters to lung-resident memory T cells?

Frontiers in Immunology
Tissue-resident memory T cells (TRM cells) are vital for the promotion of barrier immunity. The lung, a tissue constantly exposed to foreign pathogenic or non-pathogenic antigens, is not devoid of these cells.
Bruna Gois Macedo, Mia Y. Masuda, Henrique Borges da Silva   +2 more
doaj   +1 more source

Flexible Sensors for Robotics Tactile Perception: A Review

Advanced Robotics Research, EarlyView.
Flexible tactile sensing for robotics is reviewed through four interconnected dimensions. Physical mechanisms include piezoresistive, capacitive, piezoelectric, triboelectric, iontronic, and optical sensing. Structural design includes bioinspired, defect‐based, and MEMS‐based tactile systems.
Yu Song, Ying Chen, Yihao Chen, Xue Feng
wiley   +1 more source

Transcriptional programming of tissue-resident memory CD8+ T cells [PDF]

, 2018
Tissue-resident memory CD8+ T cells (TRM) are localized in non-lymphoid tissues throughout the body where they mediate long-lived protective immunity at common sites of pathogen exposure.
Goldrath, Ananda W, Milner, J Justin, J Justin Milner, Ananda W Goldrath   +3 more
core   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Dynamic Metabolic State of Tissue Resident CD8 T Cells

Frontiers in Immunology, 2019
In the past years, there have been significant advances in the understanding of how environmental conditions alone or in conjunction with pathogen invasion affect the metabolism of T cells, thereby influencing their activation, differentiation, and ...
Špela Konjar, Marc Veldhoen
doaj   +1 more source

CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells

, 2019
Data source: Supplementary information, https://doi.org/10.1038/s41590-019-0494-yTissue-resident memory T cells (TRM cells) are crucial mediators of adaptive immunity in nonlymphoid tissues.
Kokubo, K., Tobe, K., Kumagai, J., Goto, Y., Morimoto, Y., Ami Aoki, Onodera, A., Yuki Morimoto, Jin Kumagai, Damon J. Tumes, Naoko Mato, Koichi Hagiwara, Mato, N., Tim Sparwasser, Kiuchi, M., Yutaka Inagaki, Aoki, A., Yoshiyuki Goto, Tumes, D.J., Inagaki, Y., Kazuyuki Tobe, Atsushi Onodera, Toshinori Nakayama, Kiyoshi Hirahara, Nakayama, T., Sparwasser, T., Hagiwara, K., Kota Kokubo, Masahiro Kiuchi, Tomomi Ichikawa, Ichikawa, T., Hirahara, K.   +31 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Pulmonary immunization with recombinant influenza A virus stimulates M. tuberculosis-specific CD4(+) tissue resident memory T cells in the lung

, 2016
Pulmonary immunization with recombinant influenza A virus stimulates M.
M Florido (13658302), M Palendira (13658305), John Stambas (13077333), L Lin (7746038), H Muflihah (13405593), WJ Britton (7793780)   +5 more
core  

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source