Results 161 to 170 of about 17,677,818 (279)

Tissue-resident memory T cells in the nasal mucosa: gatekeepers of chronicity and relapse in allergic rhinitis. [PDF]

Front Immunol
Han X, Li F, Yang Q, Liu C, Ruan Y, He W, Li C, Chen T, Huang B, Liu G, Feng W.   +10 more
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Distinct tissue niches contribute to prostate tissue-resident memory T cell differentiation and heterogeneity 2256438

Introduction The prostate is an exocrine organ, a barrier tissue to the male reproductive system, and a site of malignancy, yet prostate tissue-resident memory T cells and the unique cues in the tissue environment remain unexplored.
Amir Ferry, Kianoosh Mempel, Jack Johanneson, Kitty Cheung, Stephanie Anover-Sombke, Natalie Zane, Julien Ishibashi, Baxter Melisso, Sara Quon, Ananda Goldrath, Ethan Xu, Nina Estep, Peter Challita, Maximilian Heeg, Miguel Reina-Campos, Giovanni Galletti, Nicole Scharping, Rana McKay, Kennidy Takehara, Vida Luna, Violante Olivari, Alexander Monell, Peter Skene   +22 more
core   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Tissue-resident memory T cells keep cancer dormant [PDF]

Cell Research, 2019
Sarah Sharon, Gabriel, Axel, Kallies
openaire   +2 more sources

Upper respiratory tract CD8+ tissue-resident memory T cells protect against viral transmission. [PDF]

J Exp Med
Michalets SE, Soto-Vazquez Y, Moore KM, Williams ME, Saha A, Jimenez A, Huang YS, Lowen AC, Scharer CD, Swaims-Kohlmeier A, Antia R, Kohlmeier JE.   +11 more
europepmc   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

Human lungs maintain tissue-resident memory T cells against a broad spectrum of pathogens. [PDF]

Nat Immunol
Fajardo-Rosas V, Ehtram A, Marchand-Casas I, Chee SJ, Mondal M, Ferrández Alaminos C, Castañeda-Castro FE, Roy Z, Chudley L, Shackcloth M, Cave J, Alzetani A, Woo E, Phillips E, Mallal S, Grifoni A, Schmiedel BJ, Sette A, Peters B, Ottensmeier CH, Vijayanand P.   +20 more
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Tissue-resident memory T cells in atopic dermatitis: mechanisms of residual inflammation, relapse, and therapeutic persistence. [PDF]

Front Immunol
Zdanowska N, Machoń N, Frączek A, Kasprowicz-Furmańczyk M, Czerwińska J, Owczarczyk-Saczonek A.   +5 more
europepmc   +1 more source