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Tissue-Specific Differentiation of CD8+ Resident Memory T Cells
Trends in Immunology, 2021CD8+ tissue-resident memory T (TRM) cells play crucial roles in defense against infections and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice and humans, they exist in all nonlymphoid organs and share key characteristics across all tissues, including downregulation of tissue egress and lymph node homing pathways ...
Axel Kallies
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Peripheral tissue surveillance and residency by memory T cells
Trends in Immunology, 2013T cell immunity has long been described in terms of two circulating memory populations. Central memory T (T(CM)) cells migrate between the secondary lymphoid organs and are capable of mounting a recall proliferative response on pathogen re-encounter, whereas effector memory T (T(EM)) cells traffic between blood and extralymphoid compartments for ...
Thomas, Gebhardt +3 more
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Tissue-Resident Memory T Cells in Cancer Immunosurveillance
Trends in Immunology, 2019Following their activation and expansion in response to foreign threats, many T cells are retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8+ memory T (TRM) cells patrol barrier surfaces and nonlymphoid organs, where their critical role in protecting against viral and bacterial infections is well established ...
Simone L, Park +2 more
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Tissue-Resident Memory T Cells in Allergy
Clinical Reviews in Allergy & ImmunologyTissue-resident memory T (TRM) cells constitute a distinct subset within the memory T cell population, serving as the vanguard against invading pathogens and antigens in peripheral non-lymphoid tissues, including the respiratory tract, intestines, and skin.
Bojin, Long +8 more
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Behavior and Function of Tissue-Resident Memory T cells
2012Our understanding of memory T cell function in mice and men is to date in large part restricted to the behavior of circulating memory T cells. Emerging evidence, however, suggests that in addition to such systemic memory T cell populations, a separate population of locally confined memory T cells is generated at former sites of antigen encounter. Here,
Silvia, Ariotti +2 more
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Tissue resident memory T cells in respiratory infections
Current Opinion in Infectious DiseasesPurpose of review We review the latest evidence that respiratory tissue resident memory T (T RM ) cells are key to local and immediate adaptive immunity to bacterial and viral infections of the respiratory tract and the implication for the design
Karen N, McCarthy, Kingston H G, Mills
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Axes of heterogeneity in human tissue‐resident memory T cells
Immunological Reviews, 2023SummaryTissue‐resident memory T cells (TRM) represent a dedicated layer of localized immune memory in virtually every organ throughout the human body. By virtue of their long‐term residence in disparate tissues, TRM are shaped by a myriad of site‐specific influences and exhibit remarkable heterogeneity in form and function.
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CD8+ Tissue-Resident Memory T Cells: Versatile Guardians of the Tissue
The Journal of ImmunologyAbstract Tissue-resident memory T (Trm) cells are a subset of T cells maintained throughout life within nonlymphoid tissues without significant contribution from circulating memory T cells. CD8+ Trm cells contribute to both tissue surveillance and direct elimination of pathogens through a variety of mechanisms.
Giuseppina Marchesini Tovar +2 more
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Memory T Cell Subsets, Migration Patterns, and Tissue Residence
Annual Review of Immunology, 2013Tissues such as the skin and mucosae are frequently exposed to microbial pathogens. Infectious agents must be quickly and efficiently controlled by our immune system, but the low frequency of naive T cells specific for any one pathogen means dependence on primary responses initiated in draining lymph nodes, often allowing time for ...
Scott N, Mueller +3 more
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Resident memory T cells call the shots in tissue immunity
ImmunityVaccines that induce immunity in tissues are urgently needed. In this issue of Immunity, Joag et al. demonstrate that systemic vaccination of primates induces tissue-resident CD8+ T cells in numerous organs that can activate antiviral responses by stromal, parenchymal, and immune cells.
Sigrun, Stulz, Georg, Gasteiger
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