Results 181 to 190 of about 26,024 (216)
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Purification and properties of native titin
Journal of Molecular Biology, 1984A procedure has been developed for the extraction and purification of the massive myofibrillar protein titin without exposing it to denaturing conditions. The form of the molecule that has been isolated is soluble at high ionic strength and alkaline pH, but precipitates in low salt or at pH values below 7.
J, Trinick, P, Knight, A, Whiting
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Nature, 1998
The gigantic muscle protein titin is a scaffold upon which the contractile units of striated muscle are assembled. Its catalytic domain is a protein kinase, and this region has now been crystallized. The structure reveals several surprises about the function of the titin kinase, and should help us to work out how this enzyme is regulated.
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The gigantic muscle protein titin is a scaffold upon which the contractile units of striated muscle are assembled. Its catalytic domain is a protein kinase, and this region has now been crystallized. The structure reveals several surprises about the function of the titin kinase, and should help us to work out how this enzyme is regulated.
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Biofizika, 2007
The titin isoform composition in skeletal and cardiac muscles of humans and animals has been studied using SDS elecrtophoresis in agarose-strengthened 1.3-2.3% polyacrylamide gels modified by us and immunoblot analysis in order to reveal new titin isoforms with molecular weights of more than 3700 kDa.
I M, Vikhliantsev, Z A, Podlubnaia
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The titin isoform composition in skeletal and cardiac muscles of humans and animals has been studied using SDS elecrtophoresis in agarose-strengthened 1.3-2.3% polyacrylamide gels modified by us and immunoblot analysis in order to reveal new titin isoforms with molecular weights of more than 3700 kDa.
I M, Vikhliantsev, Z A, Podlubnaia
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Titin: properties and family relationships
Nature Reviews Molecular Cell Biology, 2003In striated muscles, the rapid production of macroscopic levels of force and displacement stems directly from highly ordered and hierarchical protein organization, with the sarcomere as the elemental contractile unit. There is now a wealth of evidence indicating that the giant elastic protein titin has important roles in controlling the structure and ...
Larissa, Tskhovrebova, John, Trinick
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Structure and function of titin and nebulin
Current Opinion in Cell Biology, 1995Recent investigations of titin anchorage and elasticity have been supplemented with in vitro expression studies on isolated domains of titin and nebulin. These have yielded new insights into the molecular basis of the functions of these proteins in muscle.
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