Results 191 to 200 of about 22,741 (230)
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Shiver me titin! Elucidating titin's role in shivering thermogenesis
Journal of Experimental Biology, 2015ABSTRACT Shivering frequency scales predictably with body mass and is 10 times higher in a mouse than a moose. The link between shivering frequency and body mass may lie in the tuning of muscle elastic properties. Titin functions as a muscle ‘spring’, so shivering frequency may be linked to titin's structure.
Kari R, Taylor-Burt +4 more
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Titin as a Chromosomal Protein
2000We identified titin as a chromosomal protein using a human autoimmune scleroderma serum. We cloned the corresponding gene in the fruitfly, Drosophila melanogaster. We have demonstrated that titin is not only expressed and localized in striated muscle but is also distributed uniformly on condensed mitotic chromosomes using multiple antibodies directed ...
C, Machado, D J, Andrew
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1999
Abstract The name connectin was originally used in 1977 to designate a SOS-insoluble protein mixture from exhaustively extracted striated muscle. Subsequent isolation of titin from the ‘connectin’ fraction in 1981 led to the synonymous usage of titin and connectin in recent literature.
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Abstract The name connectin was originally used in 1977 to designate a SOS-insoluble protein mixture from exhaustively extracted striated muscle. Subsequent isolation of titin from the ‘connectin’ fraction in 1981 led to the synonymous usage of titin and connectin in recent literature.
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Biophysics, 2006
By our modified SDS gel electrophoresis and immunoblotting, the isoform composition of titin in skeletal and cardiac muscles of human and animals was studied to reveal new titin forms above 3700 kDa in size. The data obtained suggest that the new large-size titin species are the intact (original) isoforms of this protein, whereas the known N2A, N2B ...
I. M. Vikhlyantsev, Z. A. Podlubnaya
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By our modified SDS gel electrophoresis and immunoblotting, the isoform composition of titin in skeletal and cardiac muscles of human and animals was studied to reveal new titin forms above 3700 kDa in size. The data obtained suggest that the new large-size titin species are the intact (original) isoforms of this protein, whereas the known N2A, N2B ...
I. M. Vikhlyantsev, Z. A. Podlubnaya
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Nature, 1998
The gigantic muscle protein titin is a scaffold upon which the contractile units of striated muscle are assembled. Its catalytic domain is a protein kinase, and this region has now been crystallized. The structure reveals several surprises about the function of the titin kinase, and should help us to work out how this enzyme is regulated.
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The gigantic muscle protein titin is a scaffold upon which the contractile units of striated muscle are assembled. Its catalytic domain is a protein kinase, and this region has now been crystallized. The structure reveals several surprises about the function of the titin kinase, and should help us to work out how this enzyme is regulated.
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Titin antibodies in myasthenia gravis
Neurology, 1993Approximately 15% of patients with myasthenia gravis (MG) have thymus neoplasia. These MG with thymoma (MGT) patients show autoantibodies to striated muscle as well as autoantibodies to acetylcholine receptor. To characterize these thymoma-associated muscle antigens, we cloned a number of immunopositive cDNAs by immunoscreening muscle cDNA libraries ...
M, Gautel +9 more
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Titin--Springing Back to Youth?
Science of Aging Knowledge Environment, 2002Mutations in the muscle protein titin have been linked to dilated cardiomyopathy, a condition in which the heart chambers are enlarged and blood is ineffectively pumped, in humans and in animal models. This protein, which is a component of sarcomeres, provides essential scaffolding for other muscle proteins and acts as a spring to confer passive ...
Fawzia, Huq +2 more
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Purification and properties of native titin
Journal of Molecular Biology, 1984A procedure has been developed for the extraction and purification of the massive myofibrillar protein titin without exposing it to denaturing conditions. The form of the molecule that has been isolated is soluble at high ionic strength and alkaline pH, but precipitates in low salt or at pH values below 7.
J, Trinick, P, Knight, A, Whiting
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Titin: properties and family relationships
Nature Reviews Molecular Cell Biology, 2003In striated muscles, the rapid production of macroscopic levels of force and displacement stems directly from highly ordered and hierarchical protein organization, with the sarcomere as the elemental contractile unit. There is now a wealth of evidence indicating that the giant elastic protein titin has important roles in controlling the structure and ...
Larissa, Tskhovrebova, John, Trinick
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Titin folding energy and elasticity
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1993Molecules of the giant protein titin are responsible for the passive elasticity and central A-band location of muscle myofibrils. The molecular mechanism of titin elasticity is not known, but the I-band region of the molecule appears capable of approximately fourfold reversible extension.
Soteriou, A +3 more
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