Results 171 to 180 of about 26,024 (216)
A “Force Buffer” Protecting Immunoglobulin Titin† [PDF]
Angewandte Chemie - International Edition, 2010 The adventures of titin: in vertebrates, titin filaments control the extendibility of the muscle sarcomere. The titin immunoglobulin 27 unfolds through an intermediate (see structure; arrow: hydrogen bonds ruptured to reach intermediate) that it is ...
Helmut Grubmüller +2 more
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Biochemistry (Moscow), 2017
This review considers data on structural and functional features of titin, on the role of this protein in determination of mechanical properties of sarcomeres, and on specific features of regulation of the stiffness and elasticity of its molecules, amyloid aggregation of this protein in vitro, and possibilities of formation of intramolecular amyloid ...
E I, Yakupova +4 more
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This review considers data on structural and functional features of titin, on the role of this protein in determination of mechanical properties of sarcomeres, and on specific features of regulation of the stiffness and elasticity of its molecules, amyloid aggregation of this protein in vitro, and possibilities of formation of intramolecular amyloid ...
E I, Yakupova +4 more
openaire +2 more sources
Journal of Autoimmunity, 1997
More than 90% of myasthenia gravis (MG) patients with a thymoma have antibodies against titin. We have identified titin mRNA transcripts in thymomas by RT-PCR and Southern blotting. The transcripts cover the main immunogenic region (MIR) and a central I-band epitope reactive with some MG patients' antibodies.
G O, Skeie +6 more
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More than 90% of myasthenia gravis (MG) patients with a thymoma have antibodies against titin. We have identified titin mRNA transcripts in thymomas by RT-PCR and Southern blotting. The transcripts cover the main immunogenic region (MIR) and a central I-band epitope reactive with some MG patients' antibodies.
G O, Skeie +6 more
openaire +2 more sources
Titin in muscular dystrophy and cardiomyopathy: Urinary titin as a novel marker
Clinica Chimica Acta, 2019Titin, encoded by the gene TTN, is the largest human protein, and plays central roles in sarcomeric structures and functions in skeletal and cardiac muscles. Mutations of TTN are causally related to specific types of muscular dystrophies and cardiomyopathies.
Tomofumi Misaka +2 more
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Shiver me titin! Elucidating titin's role in shivering thermogenesis
Journal of Experimental Biology, 2015ABSTRACT Shivering frequency scales predictably with body mass and is 10 times higher in a mouse than a moose. The link between shivering frequency and body mass may lie in the tuning of muscle elastic properties. Titin functions as a muscle ‘spring’, so shivering frequency may be linked to titin's structure.
Kari R, Taylor-Burt +4 more
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Biophysics, 2006
By our modified SDS gel electrophoresis and immunoblotting, the isoform composition of titin in skeletal and cardiac muscles of human and animals was studied to reveal new titin forms above 3700 kDa in size. The data obtained suggest that the new large-size titin species are the intact (original) isoforms of this protein, whereas the known N2A, N2B ...
I. M. Vikhlyantsev, Z. A. Podlubnaya
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By our modified SDS gel electrophoresis and immunoblotting, the isoform composition of titin in skeletal and cardiac muscles of human and animals was studied to reveal new titin forms above 3700 kDa in size. The data obtained suggest that the new large-size titin species are the intact (original) isoforms of this protein, whereas the known N2A, N2B ...
I. M. Vikhlyantsev, Z. A. Podlubnaya
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Titin as a Chromosomal Protein
2000We identified titin as a chromosomal protein using a human autoimmune scleroderma serum. We cloned the corresponding gene in the fruitfly, Drosophila melanogaster. We have demonstrated that titin is not only expressed and localized in striated muscle but is also distributed uniformly on condensed mitotic chromosomes using multiple antibodies directed ...
C, Machado, D J, Andrew
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1999
Abstract The name connectin was originally used in 1977 to designate a SOS-insoluble protein mixture from exhaustively extracted striated muscle. Subsequent isolation of titin from the ‘connectin’ fraction in 1981 led to the synonymous usage of titin and connectin in recent literature.
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Abstract The name connectin was originally used in 1977 to designate a SOS-insoluble protein mixture from exhaustively extracted striated muscle. Subsequent isolation of titin from the ‘connectin’ fraction in 1981 led to the synonymous usage of titin and connectin in recent literature.
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Titin antibodies in myasthenia gravis
Neurology, 1993Approximately 15% of patients with myasthenia gravis (MG) have thymus neoplasia. These MG with thymoma (MGT) patients show autoantibodies to striated muscle as well as autoantibodies to acetylcholine receptor. To characterize these thymoma-associated muscle antigens, we cloned a number of immunopositive cDNAs by immunoscreening muscle cDNA libraries ...
M, Gautel +9 more
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Titin--Springing Back to Youth?
Science of Aging Knowledge Environment, 2002Mutations in the muscle protein titin have been linked to dilated cardiomyopathy, a condition in which the heart chambers are enlarged and blood is ineffectively pumped, in humans and in animal models. This protein, which is a component of sarcomeres, provides essential scaffolding for other muscle proteins and acts as a spring to confer passive ...
Fawzia, Huq +2 more
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