Results 181 to 190 of about 17,805,524 (287)

Eczema and food allergy in an Italian pediatric cohort: no association with TLR-2 and TLR-4 polymorphism

, 2010
Recent studies have indicated that Toll-like receptor polymorphisms or their impaired signalling, specifically TLR-2 and TLR-4, were correlated with a higher risk for allergy.
CORLETO, Vito Domenico, PAGNINI C, AVITABILE S, DELLE FAVE, Gianfranco, CIUCCI A, GALLI E, CERSOSIMO S, MANCINO G   +7 more
core  

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Serum TLR2 and S100B in Substance Abuse: A Clinical Perspective

International Journal of Medical Toxicology and Forensic Medicine
Background: Substance abuse leads to blood-brain barrier dysfunction and activation of neuro-inflammatory pathways. However, the contribution of serum levels of Toll-like receptor 2 (TLR-2) and S100 calcium-binding protein B (S100B) to neuropsychological
Babak Mostafazadeh, Mahtab Ramezani, Leila Simani, Shahin Shadnia, Fatemeh Abbaszadeh, Peyman Erfantalab Evini, Somayeh Monjazeb, Mitra Rahimi, Hossein Pakdaman, Faezeh Maghsudloo   +9 more
doaj  

<i>Porphyromonas gingivalis</i> Lysate Induces TLR-2/4-Dependent NF-κB Activation and Inflammatory Damage in the Human Placental Barrier. [PDF]

Int J Mol Sci
Araneda-Rojas S, Castillo C, Liempi A, Fernández-Moya A, Guerrero-Muñoz J, Alfaro S, Gallardo C, Arregui R, Hoare A, Gleisner MA, Hernández M, Kemmerling U.   +11 more
europepmc   +1 more source

Erratum: Author correction to "Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy" [Acta Pharm Sin B 14 (2024) 3205-3217]. [PDF]

Acta Pharm Sin B
Zhang BC, Lai CM, Luo BY, Shao JW.
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

A Chimeric Peptide Derived from a Bacterial Effector Protein Attenuates TLR-2/4-Mediated Production of Pro-Inflammatory Cytokines and Enhances the Cellular Availability of Gentamicin. [PDF]

J Inflamm Res
Nandi BR, Patra B, Radhakrishnan GK.
europepmc   +1 more source

Associations of Outdoor Air Pollution With Incidence of Cancers Other Than Lung Cancer in a Large US Prospective Cohort

International Journal of Cancer, EarlyView.
Associations between outdoor air pollution and cancers other than lung cancer remain unclear, particularly in the context of tobacco use. Here, the authors assessed possible links between ambient air pollutant exposure and incidence of 20 non‐lung cancers among adults followed over a 25‐year period in the United States.
W. Ryan Diver, Lauren R. Teras, Emily L. Deubler, Alpa V. Patel, Michelle C. Turner   +4 more
wiley   +1 more source

Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-<i>κ</i>B pathway. [PDF]

Front Pharmacol
Dong Z, Dong Z, Xu L, Zhang J, Li L, Wang R, Huang X, Zou Z.   +7 more
europepmc   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source