Results 181 to 190 of about 150,598 (283)

A Chimeric Peptide Derived from a Bacterial Effector Protein Attenuates TLR-2/4-Mediated Production of Pro-Inflammatory Cytokines and Enhances the Cellular Availability of Gentamicin. [PDF]

J Inflamm Res
Nandi BR, Patra B, Radhakrishnan GK.
europepmc   +1 more source

Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-<i>κ</i>B pathway. [PDF]

Front Pharmacol
Dong Z, Dong Z, Xu L, Zhang J, Li L, Wang R, Huang X, Zou Z.   +7 more
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Features of toll-like receptor genes (TLR-2, TLR-3, TLR-4 and TLR-6) polymorphism in open-angle glaucoma patients. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Shevchenko AV, Prokofiev VF, Konenkov VI, Chernykh VV, Trunov AN.   +4 more
europepmc   +1 more source

Associations of Outdoor Air Pollution With Incidence of Cancers Other Than Lung Cancer in a Large US Prospective Cohort

International Journal of Cancer, EarlyView.
Associations between outdoor air pollution and cancers other than lung cancer remain unclear, particularly in the context of tobacco use. Here, the authors assessed possible links between ambient air pollutant exposure and incidence of 20 non‐lung cancers among adults followed over a 25‐year period in the United States.
W. Ryan Diver, Lauren R. Teras, Emily L. Deubler, Alpa V. Patel, Michelle C. Turner   +4 more
wiley   +1 more source

Variants rs3804099 and rs3804100 in the TLR2 Gene Induce Different Profiles of TLR-2 Expression and Cytokines in Response to Spike of SARS-CoV-2. [PDF]

Int J Mol Sci
Flores-González J, Monroy-Rodríguez Z, Falfán-Valencia R, Buendía-Roldán I, Fricke-Galindo I, Hernández-Zenteno R, Herrera-Sicairos R, Chávez-Galán L, Pérez-Rubio G.   +8 more
europepmc   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Sulfate-Reducing Bacteria Induce Pro-Inflammatory TNF-α and iNOS via PI3K/Akt Pathway in a TLR 2-Dependent Manner. [PDF]

Microorganisms
Singh SB, Braun CA, Carroll-Portillo A, Coffman CN, Lin HC.   +4 more
europepmc   +1 more source

Upstream stimulatory factor 2 (USF2) induced upregulation of triggering receptor expressed on myeloid cells 1 (TREM1) promotes endometritis by regulating toll-like receptor (TLR) 2/4-nuclear factor-kappaB (NF-κB) signaling pathway. [PDF]

Bioengineered, 2022
Zhang M, Yin C, Chen Y, Wang J, Jiang J.
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source