Results 291 to 300 of about 11,832,408 (324)

Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases

Pharmacological Reports
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A diverse set of cell signaling mediators and their interactions play critical roles in neuroinflammation. The release of pro-inflammatory mediators in response to neural dysfunction is detrimental to normal cell
Veerta Sharma, Prateek Sharma, T. Singh
semanticscholar   +3 more sources

TLR-4 Signaling in Pericytes

2021
Introduction Pericytes are cells with intriguing properties that have only recently attracted the attention of numerous researchers. In the past years, their function was mainly associated with microvascular homeostasis, angiogenesis and maintenance of blood-tissue barriers.
Stasi, Alessandra, Franzin, Rossana, Netti, Giuseppe Stefano, Ranieri, Elena, Gesualdo, Loreto, Stallone, Giovanni, Castellano, Giuseppe   +6 more
openaire   +2 more sources

TLR-4 polymorphisms and leukocyte TLR-4 expression in febrile UTI and renal scarring

Pediatric Nephrology, 2013
In this study, we aimed to determine the relation of TLR-4 Asp299Gly and Thr399Ile polymorphisms and monocyte/neutrophil TLR-4 expression to febrile urinary tract infection (UTI) and renal scar development in children.The study was performed in children with a history of febrile UTI.
Kızıldağ, Sefa, Ateş, Halil, Soylu, Alper, Kavukçu, Salih, Torun Bayram, Meral   +4 more
openaire   +3 more sources

Quercetin Modulates Nrf2 and NF-κB/TLR-4 Pathways to Protect against Isoniazid and Rifampicin Induced Hepatotoxicity in vivo.

Canadian Journal of Physiology and Pharmacology, 2021
Isoniazid and rifampicin are crucial for treating tuberculosis (TB); however, they can cause severe hepatotoxicity leading to liver failure. Therapeutic options are limited and ineffective.
Sukumaran Sanjay, C. Girish, P. Toi, Z. Bobby   +3 more
semanticscholar   +1 more source

Hemorrhage-induced acute lung injury is TLR-4 dependent

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2004
Toll-like receptor 4 (TLR-4), initially identified as an LPS receptor, is critical to the signaling of a variety of danger signals, including heat shock protein 60, fibrinogen, and fibronectin. Recent data also suggest that TLR-4 plays a role in determining survival in both endotoxemia and hemorrhagic shock.
Katherine A, Barsness, John, Arcaroli, Alden H, Harken, Edward, Abraham, Anirban, Banerjee, Leonid, Reznikov, Robert C, McIntyre   +6 more
openaire   +2 more sources

TLR-2 Arg753Gln, TLR-4 Asp299Gly, and TLR-4 Thr399Ile polymorphisms in Henoch Schonlein purpura with and without renal involvement

Rheumatology International, 2009
Infections may trigger or aggravate glomerulonephritidis and renal vasculitis like Henoch Schonlein purpura (HSP). HSP is seen more frequently in patients with familial Mediterranean fever in which TLR-2 Arg753Gln polymorphism frequency is increased. Although renal involvement is the most important factor affecting the prognosis in HSP, it is not known
CİNGÖZ, SULTAN, KIZILDAĞ, SEFA, Sakizli, Meral, KAVUKÇU, SALİH, Turkmen, Mehmet, Demir, Belde Kasap, SOYLU, ALPER   +6 more
openaire   +3 more sources

TLR‐4 targeting contributes to the recovery of osteoimmunology in periodontitis

Journal of Periodontal Research, 2021
AbstractObjectiveThe aim of this study was to determine the potential role of TLR‐4 in the osteoimmunological imbalance of periodontitis.BackgroundAlthough current evidence supports that TLR‐4 plays an important role in the inflammatory response of periodontal tissues triggered by microorganisms, little information is available regarding the function ...
Xi Yang, Xiaoan Tao, Weijuan Qi, Zhao Liu, Yamin Wang, Qianqian Han, Chenrong Xu   +6 more
openaire   +2 more sources

Immune Response Against Sporothrix schenckii in TLR-4-Deficient Mice

Mycopathologia, 2012
For many fungal diseases, macrophages are the major cell population implicated in host protection, primarily by their ability to eliminate the invading fungal pathogen through phagocytosis. In sporotrichosis, this remains true, because of macrophages’ ability to recognize Sporothrix schenckii through specific receptors for some of the fungus’ cellular ...
Sassa, Micheli Fernanda, Ferreira, Lucas Souza, de Abreu Ribeiro, Livia Carolina, Carlos, Iracilda Zeppone   +3 more
openaire   +3 more sources

HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2

Shock, 2006
In response to bacterial endotoxin (e.g., LPS) or endogenous proinflammatory cytokines (e.g., TNF and IL-1beta), innate immune cells release HMGB1, a late cytokine mediator of lethal endotoxemia and sepsis. The delayed kinetics of HMGB1 release makes it an attractive therapeutic target with a wider window of opportunity for the treatment of lethal ...
Man, Yu, Haichao, Wang, Aihao, Ding, Douglas T, Golenbock, Eicke, Latz, Christopher J, Czura, Matthew J, Fenton, Kevin J, Tracey, Huan, Yang   +8 more
openaire   +2 more sources

Brucella abortus induces mast cell activation through TLR-2 and TLR-4

Microbial Pathogenesis, 2023
The Gram-negative bacteria Brucella abortus is a major cause of brucellosis in animals and humans. The host innate immune response to B. abortus is mainly associated with phagocytic cells such as dendritic cells, neutrophils, and macrophages. However, as mast cells naturally reside in the main bacterial entry sites they may be involved in bacterial ...
Adriana Dominguez-Flores, Gloria M. Rodríguez López, Rodolfo Soria-Castro, Rubén López-Santiago, Octavio Rodríguez-Cortés, Sonia M. Pérez-Tapia, Alma D. Chávez-Blanco, Sergio Estrada-Parra, Raúl Flores-Mejía, Rommel Chacón-Salinas   +9 more
openaire   +2 more sources