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TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS [PDF]

, 2013
The study included 70 patients with a transplanted kidney and 50 healthy volunteers representing a control group. Median age of the transplanted patients was 53 years (48-58 years). Transplanted patients had been receiving an adjuvant kidney therapy for an average of 4 years (2-6 years).
Glavaš, Josipa, Sesar, Sanda, Alkhamis, Tamara, Kralik, Kristina, Prlić, Damir, Barbić, Jerko   +5 more
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Imidacloprid induced histomorphological changes and expression of TLR-4 and TNFα in lung

Pesticide Biochemistry and Physiology, 2016
The imidacloprid is used worldwide as a pesticide and has been linked with endocrine disturbances and reduced pulmonary function. However, effects of imidacloprid alone or in combination with microbial molecules on lungs are not fully understood. Because the pulmonary effects of interactions of endotoxins with imidacloprid are unknown, we designed a ...
Arif Ahmad, Pandit, Shanti, Choudhary, , Ramneek, Baljit, Singh, R S, Sethi   +4 more
openaire   +2 more sources

Immune Response Against Sporothrix schenckii in TLR-4-Deficient Mice

Mycopathologia, 2012
For many fungal diseases, macrophages are the major cell population implicated in host protection, primarily by their ability to eliminate the invading fungal pathogen through phagocytosis. In sporotrichosis, this remains true, because of macrophages’ ability to recognize Sporothrix schenckii through specific receptors for some of the fungus’ cellular ...
Sassa, Micheli Fernanda, Ferreira, Lucas Souza, de Abreu Ribeiro, Livia Carolina, Carlos, Iracilda Zeppone   +3 more
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Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.

The American journal of pathology, 2003
Acute lung injury (ALI) leading to respiratory distress is a common sequela of shock/trauma, however, modeling this process in mice with a single shock or septic event is inconsistent. One explanation is that hemorrhage is often just a "priming insult," thus, secondary stimuli may be required to "trigger" ALI.
Alfred, Ayala, Chun-Shiang, Chung, Joanne L, Lomas, Grace Y, Song, Lesley A, Doughty, Stephen H, Gregory, William G, Cioffi, Brian W, LeBlanc, Jonathan, Reichner, H Hank, Simms, Patricia S, Grutkoski   +10 more
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Expression and Subcellular Localization of TLR-4 in Term and First Trimester Human Placenta

Placenta, 2006
Toll-like receptor 4 (TLR-4) mediates Gram-negative bacterial-induced inflammatory responses, including production of pro-inflammatory cytokines. Maternal infection and inflammation play an important role in preterm birth and neonatal brain damage. The localization of placental TLR-4 as well as changes during normal gestation are critical issues in ...
E C E, Beijar, C, Mallard, T L, Powell
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“Monovalent” ligands that trigger TLR-4 and TCR are not necessarily truly monovalent

Molecular Immunology, 2012
Cell surface receptors mediate many cellular responses in health and disease. Recent progress in our understanding of how ligand binding to the extracellular domains of receptors triggers intracellular signaling has underlined the role of ligand-promoted receptor clustering following by oligomerization of the cytoplasmic signaling domains.
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Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases

Pharmacological Reports
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A diverse set of cell signaling mediators and their interactions play critical roles in neuroinflammation. The release of pro-inflammatory mediators in response to neural dysfunction is detrimental to normal cell
Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh   +2 more
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Investigating TLR-4 signalling in response to protein ligands

2018
Toll-like receptor (TLR)-4 is a pattern recognition receptor (PRR) that recognises the pathogen-associated molecular pattern (PAMP) lipopolysaccharide (LPS) produced by Gram-negative bacteria. LPS binds to Myeloid differentiation 2 (MD-2)/TLR-4 heterodimers, driving their dimerisation and inducing a conformational change of the intracellular TLR-4 toll/
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TLR-4 Signaling vs. Immune Checkpoints, miRNAs Molecules, Cancer Stem Cells, and Wingless-Signaling Interplay in Glioblastoma Multiforme—Future Perspectives

International Journal of Molecular Sciences, 2020
Jakub Litak, Cezary Grochowski, Krzysztof Gosik   +2 more
exaly  

Effects of Exercise Training on TLR-4 Expression

Medicine & Science in Sports & Exercise, 2006
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