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TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS [PDF]

, 2013
The study included 70 patients with a transplanted kidney and 50 healthy volunteers representing a control group. Median age of the transplanted patients was 53 years (48-58 years). Transplanted patients had been receiving an adjuvant kidney therapy for an average of 4 years (2-6 years).
Glavaš, Josipa, Sesar, Sanda, Alkhamis, Tamara, Kralik, Kristina, Prlić, Damir, Barbić, Jerko   +5 more
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Melanoma cell lines are responsive in vitro to lipopolysaccharide and express TLR-4

Cancer Letters, 2006
Endotoxin/lipopolysacccharide (LPS) is a potent inflammatory stimulus, which acts on tumour infiltrating leukocytes by eliciting a wide range of factors promoting invasion and metastasis. Less known is the effect of LPS directly on tumour cells. In this study, we analysed whether tumour cell lines from different origin (melanoma, ovarian carcinoma ...
MOLTENI M, MARABELLA D, ORLANDI C, ROSSETTI, CARLO   +3 more
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Inhibition of TLR-4/MD-2 signaling by RP105/MD-1

Journal of Endotoxin Research, 2005
Activation of Toll-like receptor (TLR) signaling by microbial and host molecular signatures is critical to the induction of immune responses. Such signaling is, perforce, kept under tight control. We recently discovered a novel endogenous inhibitor of TLR-4 — RP105.
Senad, Divanovic, Aurelien, Trompette, Sowsan F, Atabani, Rajat, Madan, Douglas T, Golenbock, Alberto, Visintin, Robert W, Finberg, Alexander, Tarakhovsky, Stefanie N, Vogel, Yasmine, Belkaid, Evelyn A, Kurt-Jones, Christopher L, Karp   +11 more
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Immune Response Against Sporothrix schenckii in TLR-4-Deficient Mice

Mycopathologia, 2012
For many fungal diseases, macrophages are the major cell population implicated in host protection, primarily by their ability to eliminate the invading fungal pathogen through phagocytosis. In sporotrichosis, this remains true, because of macrophages’ ability to recognize Sporothrix schenckii through specific receptors for some of the fungus’ cellular ...
Sassa, Micheli Fernanda, Ferreira, Lucas Souza, de Abreu Ribeiro, Livia Carolina, Carlos, Iracilda Zeppone   +3 more
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Imidacloprid induced histomorphological changes and expression of TLR-4 and TNFα in lung

Pesticide Biochemistry and Physiology, 2016
The imidacloprid is used worldwide as a pesticide and has been linked with endocrine disturbances and reduced pulmonary function. However, effects of imidacloprid alone or in combination with microbial molecules on lungs are not fully understood. Because the pulmonary effects of interactions of endotoxins with imidacloprid are unknown, we designed a ...
Arif Ahmad, Pandit, Shanti, Choudhary, , Ramneek, Baljit, Singh, R S, Sethi   +4 more
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Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases

Pharmacological Reports
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A diverse set of cell signaling mediators and their interactions play critical roles in neuroinflammation. The release of pro-inflammatory mediators in response to neural dysfunction is detrimental to normal cell
Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh   +2 more
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Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.

The American journal of pathology, 2003
Acute lung injury (ALI) leading to respiratory distress is a common sequela of shock/trauma, however, modeling this process in mice with a single shock or septic event is inconsistent. One explanation is that hemorrhage is often just a "priming insult," thus, secondary stimuli may be required to "trigger" ALI.
Alfred, Ayala, Chun-Shiang, Chung, Joanne L, Lomas, Grace Y, Song, Lesley A, Doughty, Stephen H, Gregory, William G, Cioffi, Brian W, LeBlanc, Jonathan, Reichner, H Hank, Simms, Patricia S, Grutkoski   +10 more
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“Monovalent” ligands that trigger TLR-4 and TCR are not necessarily truly monovalent

Molecular Immunology, 2012
Cell surface receptors mediate many cellular responses in health and disease. Recent progress in our understanding of how ligand binding to the extracellular domains of receptors triggers intracellular signaling has underlined the role of ligand-promoted receptor clustering following by oligomerization of the cytoplasmic signaling domains.
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TLR-4 Signaling vs. Immune Checkpoints, miRNAs Molecules, Cancer Stem Cells, and Wingless-Signaling Interplay in Glioblastoma Multiforme—Future Perspectives

International Journal of Molecular Sciences, 2020
Jakub Litak, Elżbieta Radzikowska, Cezary Grochowski   +2 more
exaly  

TREATMENT OF TLR-4 MEDIATED DISEASES AND CONDITIONS WITH APTAMERS TARGETING TLR-4

2020
SEGARRA DE LA PEÑA DAVID, BOSCÁ GOMAR LISARDO, LIZASOAIN HERNÁNDEZ IGNACIO, DE CASTRO SOUBRIET FERNANDO, ZARAGOZA CARLOS, HERNÁNDEZ JIMÉNEZ MACARENA, PIÑEIRO DEL RIO DAVID, FERNANDEZ GÓMEZ BEATRIZ, MORO SÁNCHEZ MARÍA ÁNGELES, PÉREZ RODRÍGUEZ DIEGO, ZARABOZO LEAL MARÍA EUGENIA   +10 more
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