Results 261 to 270 of about 154,777 (303)

TLR‐4 targeting contributes to the recovery of osteoimmunology in periodontitis

Journal of Periodontal Research, 2021
AbstractObjectiveThe aim of this study was to determine the potential role of TLR‐4 in the osteoimmunological imbalance of periodontitis.BackgroundAlthough current evidence supports that TLR‐4 plays an important role in the inflammatory response of periodontal tissues triggered by microorganisms, little information is available regarding the function ...
Xi Yang, Xiaoan Tao, Weijuan Qi, Zhao Liu, Yamin Wang, Qianqian Han, Chenrong Xu   +6 more
openaire   +2 more sources

TLR-4 Signaling in Pericytes

2021
Introduction Pericytes are cells with intriguing properties that have only recently attracted the attention of numerous researchers. In the past years, their function was mainly associated with microvascular homeostasis, angiogenesis and maintenance of blood-tissue barriers.
Stasi, Alessandra, Franzin, Rossana, Netti, Giuseppe Stefano, Ranieri, Elena, Gesualdo, Loreto, Stallone, Giovanni, Castellano, Giuseppe   +6 more
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TLR-2 Arg753Gln, TLR-4 Asp299Gly, and TLR-4 Thr399Ile polymorphisms in Henoch Schonlein purpura with and without renal involvement

Rheumatology International, 2009
Infections may trigger or aggravate glomerulonephritidis and renal vasculitis like Henoch Schonlein purpura (HSP). HSP is seen more frequently in patients with familial Mediterranean fever in which TLR-2 Arg753Gln polymorphism frequency is increased. Although renal involvement is the most important factor affecting the prognosis in HSP, it is not known
CİNGÖZ, SULTAN, KIZILDAĞ, SEFA, Sakizli, Meral, KAVUKÇU, SALİH, Turkmen, Mehmet, Demir, Belde Kasap, SOYLU, ALPER   +6 more
openaire   +3 more sources

Hemorrhage-induced acute lung injury is TLR-4 dependent

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2004
Toll-like receptor 4 (TLR-4), initially identified as an LPS receptor, is critical to the signaling of a variety of danger signals, including heat shock protein 60, fibrinogen, and fibronectin. Recent data also suggest that TLR-4 plays a role in determining survival in both endotoxemia and hemorrhagic shock.
Katherine A, Barsness, John, Arcaroli, Alden H, Harken, Edward, Abraham, Anirban, Banerjee, Leonid, Reznikov, Robert C, McIntyre   +6 more
openaire   +2 more sources

Cloning, expression and bioinformatics analysis of the duck TLR 4 gene

British Poultry Science, 2012
1. Toll-like receptors (TLRs) are type I transmembrane proteins that play an essential role in the innate immune system. Studies on the structure and function of TLRs can be applied to the development of new approaches to control diseases of humans and animals. 2. A 3432-bp cDNA encoding duck toll-like receptor 4 (duTLR4) was cloned from duck splenic
H, Jia, G, Li, J, Li, Y, Tian, D, Wang, J, Shen, Z, Tao, J, Xu, L, Lu   +8 more
openaire   +2 more sources

Hyaluronan differently modulates TLR‐4 and the inflammatory response in mouse chondrocytes

BioFactors, 2012
AbstractHyaluronic acid (HA) may exert different action depending on its degree of polymerization. Small HA fragments induce proinflammatory responses, while highly polymerized HA exerts a protective effect in inflammatory pathologies such as rheumatoid arthritis.
CAMPO, Giuseppe Maurizio, AVENOSO, Angela, D'ASCOLA, ANGELA, Prestipino V, Scuruchi M, Nastasi G, CALATRONI, Alberto, CAMPO, Salvatore Giuseppe   +7 more
openaire   +3 more sources

TLR-4: a promising target for chemotherapy-induced peripheral neuropathy

Molecular Biology Reports
Chemotherapy-induced peripheral neuropathy (CIPN) affects a significant majority of cancer patients, with up to 80% experiencing this severe and dose-limiting side effect while undergoing anti-cancer treatment. CIPN can be induced by a variety of drugs commonly employed in the management of both solid tumors and hematologic cancers. The inadequacies in
Nagendra, Babu, Anagha, Gadepalli, , Akhilesh, Dilip, Sharma, Anurag Kumar, Singh, Deepak, Chouhan, Somesh, Agrawal, Vinod, Tiwari   +7 more
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Melanoma cell lines are responsive in vitro to lipopolysaccharide and express TLR-4

Cancer Letters, 2006
Endotoxin/lipopolysacccharide (LPS) is a potent inflammatory stimulus, which acts on tumour infiltrating leukocytes by eliciting a wide range of factors promoting invasion and metastasis. Less known is the effect of LPS directly on tumour cells. In this study, we analysed whether tumour cell lines from different origin (melanoma, ovarian carcinoma ...
MOLTENI M, MARABELLA D, ORLANDI C, ROSSETTI, CARLO   +3 more
openaire   +3 more sources

HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2

Shock, 2006
In response to bacterial endotoxin (e.g., LPS) or endogenous proinflammatory cytokines (e.g., TNF and IL-1beta), innate immune cells release HMGB1, a late cytokine mediator of lethal endotoxemia and sepsis. The delayed kinetics of HMGB1 release makes it an attractive therapeutic target with a wider window of opportunity for the treatment of lethal ...
Man, Yu, Haichao, Wang, Aihao, Ding, Douglas T, Golenbock, Eicke, Latz, Christopher J, Czura, Matthew J, Fenton, Kevin J, Tracey, Huan, Yang   +8 more
openaire   +2 more sources

Inhibition of TLR-4/MD-2 signaling by RP105/MD-1

Journal of Endotoxin Research, 2005
Activation of Toll-like receptor (TLR) signaling by microbial and host molecular signatures is critical to the induction of immune responses. Such signaling is, perforce, kept under tight control. We recently discovered a novel endogenous inhibitor of TLR-4 — RP105. Initially identified as a B-cell-specific molecule with a role in B-cell proliferation
Senad, Divanovic, Aurelien, Trompette, Sowsan F, Atabani, Rajat, Madan, Douglas T, Golenbock, Alberto, Visintin, Robert W, Finberg, Alexander, Tarakhovsky, Stefanie N, Vogel, Yasmine, Belkaid, Evelyn A, Kurt-Jones, Christopher L, Karp   +11 more
openaire   +2 more sources