Results 21 to 30 of about 138,799 (244)
OncoImmunology, 2017 Exosomes are a class of nanovesicles formed and released through the late endosomal compartment and represent an important mode of intercellular communication. The ability of anticancer chemotherapy to enhance the immunogenic potential of malignant cells
Elisabetta Vulpis +17 more
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Benefits of post-stress immunosuppression: a viewpoint from exercise immunology
Journal of Physical Fitness and Sports Medicine, 2018 In understanding the relationship between exercise and immunity, the “open window theory” is a well-known theory stating that immediately after high intensity exercise, temporary immunosuppression occurs, which increases the risk of infections such as ...
Hiromi Yano +3 more
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Emerging roles of microRNAs in the regulation of Toll-like receptor (TLR)-signaling
Frontiers in Bioscience-Landmark, 2020 Toll-like receptors (TLRs) are evolutionarily conserved molecules that detect exogenous and endogenous molecular patterns and trigger both the innate and adaptive immune systems to initiate a pathogen-specific immune response and eliminate the threat ...
Saswati Banerjee +2 more
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Digitalization of toxicology: improving preclinical to clinical translation
Frontiers in ToxicologyThough the portfolio of medicines that are extending and improving the lives of patients continues to grow, drug discovery and development remains a challenging business on its best day.
Brian R. Berridge +7 more
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Life Sciences, 2019 Toll-like receptors (TLRs) comprise a clan of proteins involved in identification and triggering a suitable response against pathogenic attacks. As lung is steadily exposed to multiple infectious agents, antigens and host-derived danger signals, the inhabiting stromal and myeloid cells of the lung express an aggregate of TLRs which perceive the ...
Arora, Shweta +10 more
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Human Plasmacytoid Dendritic Cells and Cutaneous Melanoma
Cells, 2020 The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Matilde Monti +4 more
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Diabetes, Metabolic Syndrome and Obesity, 2020 Awgichew Shewasinad Yehualashet Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, EthiopiaCorrespondence: Awgichew Shewasinad YehualashetPharmacology and Toxicology Unit ...
Yehualashet AS
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Cancer Research, 2012 Abstract MicroRNAs (miRNA) are small noncoding RNAs with gene regulatory functions. Their expression is frequently dysregulated in almost all human tumors and they can be found circulating within exosomes secreted by cancer cells. In addition to being promising cancer biomarkers with diagnostic, prognostic, and theranostic implications ...
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Human Vaccines & Immunotherapeutics, 2021 Outer membrane vesicles (OMV) are exosomes naturally released from the surface of Gram-negative bacteria. Since the ’80s, OMVs have been proposed as powerful vaccine platforms due to their intrinsic self-adjuvanticity and ability to present multiple ...
Omar Rossi +2 more
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Human Vaccines & Immunotherapeutics, 2020 Traditional non-living vaccines are often least effective in the populations that need them most, such as neonates and elderly adults. Vaccine adjuvants are one approach to boost the immunogenicity of antigens in populations with reduced immunity ...
Orli Even-Or +3 more
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