Results 21 to 30 of about 300,160 (284)
TLR Ignores Methylated RNA? [PDF]
Immunity, 2005 CpG methylation of DNA silences TLR9-mediated innate immune recognition. In this issue of Immunity, Kariko et al (2005) suggest that the innate immune recognition of RNA by TLR3, TLR7, or TLR8 is in fact controlled by modification of nucleotides, including methylation.
Ishii, Ken J., Akira, Shizuo
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Protein phosphatases in TLR signaling [PDF]
Cell Communication and Signaling, 2021 AbstractToll-like receptors (TLRs) are critical sensors for the detection of potentially harmful microbes. They are instrumental in initiating innate and adaptive immune responses against pathogenic organisms. However, exaggerated activation of TLR receptor signaling can also be responsible for the onset of autoimmune and inflammatory diseases.
Clovis H. T. Seumen +2 more
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Inflammaging as the basis of age-associated diseases
Медицинская иммунология, 2020 Aging is one of the most complex biological phenomena that affects all human physiological systems, including the immune system. Immunosenescence is understood as structural and functional changes in both adaptive and innate immunity systems.
O. V. Artemyeva, L. V. Gankovskaya
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Debugging of Web Applications with Web-TLR [PDF]
, 2011 Web-TLR is a Web verification engine that is based on the well-established Rewriting Logic--Maude/LTLR tandem for Web system specification and model-checking. In Web-TLR, Web applications are expressed as rewrite theories that can be formally verified by
Daniel Romero +19 more
core +3 more sources
Эпидемиология и вакцинопрофилактика, 2018 Vaccines for many years act as one of the most effective and successfully used medicines. Vaccines obtained by traditional methods contain in their composition live, weakened or killed microorganisms (bacteria, viruses, etc.).
O. A. Svitich +5 more
doaj +1 more source
Immunity, 2016 Two new studies published in The American Journal of Human Genetics (Dannemann et al., 2016; Deschamps et al., 2016) show that introgression of innate immune genes from Neandertals and Denisovans contributed to the modern genome of European and Asian, but not African, populations, and this might partly explain differences in susceptibility to immune ...
Netea, M.G., Joosten, L.A.B.
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Neisserial PorB immune enhancing activity and use as a vaccine adjuvant
Human Vaccines & Immunotherapeutics, 2019 Our laboratory has focused on Porin B (PorB), an outer membrane protein from Neisseria meningitidis and TLR2 ligand-based adjuvant, to characterize specific molecular and cellular pathways involved in improved immune responses induced by vaccine ...
Rachel Yuen +3 more
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OncoImmunology, 2017 Exosomes are a class of nanovesicles formed and released through the late endosomal compartment and represent an important mode of intercellular communication. The ability of anticancer chemotherapy to enhance the immunogenic potential of malignant cells
Elisabetta Vulpis +17 more
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Autoimmunity, 2021 Toll-like receptors (TLRs) are known to have an important role in triggering the innate immune response and in priming antigen-specific adaptive immunity and inflammation. The differences in synovial tissue expression of the TLRs between seronegative and
Alzahraa Abdelwahab +10 more
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The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release [PDF]
, 2013 <p>Objectives: Macrophages are central to the inflammatory processes driving rheumatoid arthritis (RA) synovitis. The molecular pathways that are induced in synovial macrophages and thereby promote RA disease pathology remain poorly understood.</
Ananth +42 more
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