Results 31 to 40 of about 183,650 (307)
Human Vaccines & Immunotherapeutics, 2021 Outer membrane vesicles (OMV) are exosomes naturally released from the surface of Gram-negative bacteria. Since the ’80s, OMVs have been proposed as powerful vaccine platforms due to their intrinsic self-adjuvanticity and ability to present multiple ...
Omar Rossi +2 more
doaj +1 more source
Cells, 2020 Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-κB pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in ...
Hsiang-Chi Huang +6 more
doaj +1 more source
, 2020 The aim: is to study the efficacy of influenza vaccination for individuals with polymorphism Arg753Gln of TLR-2 gene, Leu412Phe of TLR-3 gene, and Asp299Gly of TLR-4 gene. Materials and methods: 66 people with mutant genotypes and normal distribution of
Pryimenko, N. O. +11 more
core +1 more source
TLR staining intensity compared between NAT and US patients for each TLR.
, 2022 TLR staining intensity compared between NAT and US patients for each TLR.
Harri Mustonen (641410) +4 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Cancer Research, 2012 Abstract MicroRNAs (miRNA) are small noncoding RNAs with gene regulatory functions. Their expression is frequently dysregulated in almost all human tumors and they can be found circulating within exosomes secreted by cancer cells. In addition to being promising cancer biomarkers with diagnostic, prognostic, and theranostic implications ...
openaire +2 more sources
Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection [PDF]
, 2003 Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated TLR-4) in response to Salmonella infection.
Maskell, Duncan J +4 more
core
, 2009 Ischemia-reperfusion (I/R) activates innate immunity involving Toll-like receptor (TLR) 2 and TLR-4 signaling. Leukocyte migration and vascular permeability contribute to postischemic tissue damage.
Khandoga, AG;Khandoga, A;Anders, HJ;Krombach, F
core +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Benefits of post-stress immunosuppression: a viewpoint from exercise immunology
Journal of Physical Fitness and Sports Medicine, 2018 In understanding the relationship between exercise and immunity, the “open window theory” is a well-known theory stating that immediately after high intensity exercise, temporary immunosuppression occurs, which increases the risk of infections such as ...
Hiromi Yano +3 more
doaj +1 more source