Results 51 to 60 of about 183,650 (307)

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Vernal keratoconjunctivitis activity induces decrease of ocular surface CD14, TLR-4 and TLR-9 expression

, 2022
Purpose: CD14 is involved in the modulation of immune reaction via toll-like receptors (TLR) and may influence the development of allergic diseases. The role of CD14 in vernal keratoconjunctivitis (VKC) has not yet been investigated.
Nebbioso, Marcella, Lambiase, Alessandro, Bruscolini, Alice, Sacchetti, Marta, Segatto, Marco, Abicca, Irene, Zicari, Anna Maria   +6 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes

Mediators of Inflammation, 2010
The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it ...
Yolanda Alvarez, Isela Valera, Cristina Municio, Etzel Hugo, Francisco Padrón, Lydia Blanco, Mario Rodríguez, Nieves Fernández, Mariano Sánchez Crespo   +8 more
openaire   +4 more sources

Evidence for dissociation of TLR mRNA expression and TLR agonist-mediated functions in bovine macrophages

, 2006
Toll-like receptors are of key importance in the recognition of and response to infectious agents by cells of the innate immune system. TLR mRNA expression and TLR-mediated functions were determined in bovine macrophages (MPhi) infected with bovine viral
Sauter, Kay-Sara, Franchini, Marco, Schweizer, Matthias, Peterhans, Ernst, Jungi, Thomas W, Mirkovitch, Jelena, Mätzener, Philippe, Magkouras, Ioannis, Mätzener P, Jungi, Thomas, Magouras, Ioannis, Sauter, Kay Sara, Franchini M, Magkouras I, Mirkovitch J, Peterhans E, Sauter KS, Jungi TW, Schweizer M   +18 more
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

The role of TLR-2, TLR-3, TLR-4 genes polymorphism in case of grippe

, 2014
В данной статье изучены распространенность и прогностическое значение полиморфизма Arg753Gln гена TLR-2, Leu412Phe TLR-3, Asp299Gly TLR-4 при гриппе.
Кайдашев, Игорь Петрович, Чуб, Костянтин Федорович, Dubynska, G., Похилько, Валерий Иванович, Прийменко, Наталія Олегівна, Дубинська, Галина Михайлівна, Pryimenko, N. O., Chub, K. F., Чуб, Константин Федорович, Kaidashev, I., Pokhylko, V. I., Прийменко, Наталья Олеговна, Кайдашев, Ігор Петрович, Дубинская, Галина Михайловна, Похилько, Валерій Іванович   +14 more
core   +1 more source

Spontaneous clearance of the human papilloma virus as a result of suppressive therapy with acyclic nucleosides of a recurrent herpes-viral infection [PDF]

Гинекология, 2017
Background. Genital human papillomavirus (HPV) infection is not effectively controlled and treated. Current dates suggest that 80% cases of HPV infections are transient and clear spontaneously, it is connected with the deterministic immune response ...
N I Tapilskaya, I N Vorobtsova, R I Glushakov   +2 more
doaj  

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

Efficacy and safety of imiquimod in the treatment of subclinicaland clinical forms of persistent cervical papillomavirus infection in patients of early reproductive age [PDF]

Гинекология, 2015
Objectives. HPV infection is a major risk factor for cervix cancer. This study evaluated cervical application of imiquimodfortreatment of subclinical (flat condyloma) and clinical (CIN I, LSIL) manifestations of human papillomavirus infection.
N I Tapilskaya, I N Vorobtsova, S N Gaidukov, S N Proshin   +3 more
doaj