Results 71 to 80 of about 183,650 (307)

Coxiella burnetii lipopolysaccharide blocks p38α-MAPK activation through the disruption of TLR-2 and TLR-4 association [PDF]

, 2015
To survive in macrophages, Coxiella burnetii hijacks the activation pathway of macrophages. Recently, we have demonstrated that C. burnetii, via its lipopolysaccharide (LPS), avoids the activation of p38α-MAPK through an antagonistic engagement of Toll ...
Veronica eBaldassarre, Nicolas Boucherit, Veronica Baldassarre, Virginie Trouplin, Eric Ghigo, Jean-louis eMege, Jean-Louis Mege, Rudolf eToman, Filippo Conti, Rudolf Toman, Giovanna Mottola, Filippo eConti, Eric eGhigo, Giovanna eMottola, Nicolas eBoucherit, Virginie eTrouplin   +15 more
core   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

TLRs and innate immunity

Blood, 2009
AbstractOne of the most fundamental questions in immunology pertains to the recognition of non-self, which for the most part means microbes. How do we initially realize that we have been inoculated with microbes, and how is the immune response ignited?
openaire   +3 more sources

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Assessment of immunological efficacy of specific prevention influenza in persons with polymorphism of TLR-2, TLR-3, TLR-4 genes

, 2014
Метою дослідження було вивчення ефективності вакцинації проти грипу в осіб із поліморфізмом Arg753Gln гену TLR-2, Leu412Phe TLR-3, Asp299Gly TLR-4. Провакциновано 66 осіб із мутантними генотипами та нормальним розподілом алелей TLR-2, TLR-3, TLR-4, віком
Руденко, Станіслав Станіславович, Руденко, Станислав Станиславович, Iziumska, O. M., Артемьева, Елена Владимировна, Artemyeva, Е. V., Dubynska, G., Прийменко, Наталія Олегівна, Дубинська, Галина Михайлівна, Pryimenko, N. O., Ізюмська, Олена Михайлівна, Артемьєва, Олена Володимирівна, Rudenko, S. S., Изюмская, Елена Михайловна, Прийменко, Наталья Олеговна, Дубинская, Галина Михайловна   +14 more
core   +1 more source

Однонуклеотидные полиморфизмы TLR-2, TLR-3, TLR-4 и восприимчивость к воспалительным заболеваниям дыхательных путей [PDF]

, 2018
The aim of the research is to establish an association between Arg753Gln polymorphism of TLR-2 gene, Leu412Phe of TLR3 gene, Asp299Gly of TLR-4 gene and susceptibility to inflammatory diseases of the upper and lower respiratory tract and the complicated ...
Пікуль, Катерина Вікторівна, Кайдашев, Игорь Петрович, Dubynska, H. M., Прийменко, Наталія Олегівна, Котелевская, Татьяна Михайловна, Пикуль, Екатерина Викторовна, Дубинська, Галина Михайлівна, Pryimenko, N. O., Kotelevska, T. M., Pikul, K. V., Котелевська, Тетяна Михайлівна, Kaidashev, I. P., Кайдашев, Ігор Петрович, Прийменко, Наталья Олеговна, Дубинская, Галина Михайловна   +14 more
core   +1 more source

Investigation of Inflammation and Autophagy due to Biglycan-mediated TLR2/4 Signaling in Oral Lichen Planus Tissues [PDF]

Forbes Tıp Dergisi
Objective: Oral lichen planus (OLP) is a chronic oral mucosal disease of unknown etiology. Cellular immune response, basement membrane, and extracellular matrix (ECM) molecules are also noteworthy in the pathogenesis.
Özlem Ceren GÜNİZİ, Hüseyin GÜNİZİ, Hamiyet ECİROĞLU, Fatma YILDIZ   +3 more
doaj   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

Polysaccharides from pectinase digests of green tea enhances host immune defence through toll-like receptor 4

Food and Agricultural Immunology, 2018
To develop new immunostimulatory ingredients, green tea polysaccharides were obtained by pectinase-assisted extraction. The present study investigated the immune stimulating and protective ability of polysaccharides from pectinase digests of green tea ...
BoYoon Chang, TaeYoung Kim, SungYeon Kim
doaj   +1 more source

Dual‐Targeted Biomimetic MoSe2 Nanozymes for Enhancing Peri‐Implant Soft Tissue Integration

Advanced Science, EarlyView.
A dual‐targeting biomimetic nanozyme, MoSe2@SPMM, selectively targets Staphylococcus aureus and oxidatively stressed macrophages. Near‐infrared activation couples contact‐enhanced photothermal bacterial eradication with reactive oxygen species scavenging to disrupt the pathogenic–immunological amplification loop.
Minghao Zhou, Miaomiao Tian, Jingwei Yu, Jiaxin Kang, Miaomiao Chen, Yue Yuan, Lizhi Liu, Hongbo Wei   +7 more
wiley   +1 more source