Results 61 to 70 of about 183,650 (307)
Journal of Experimental MedicineGenetic variation in UNC93B1, a key component in TLR trafficking, can lead to autoinflammation caused by increased TLR activity. Analysis of seven patient variants combined with a comprehensive alanine screen revealed that different regions of UNC93B1 selectively regulate different TLRs (Rael et al.
Justin Taft, Dusan Bogunovic
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Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity
Advanced Science, EarlyView.Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang +11 more
wiley +1 more source
Toll-Like Receptors Expression in Follicular Cells of Patients with Poor Ovarian Response [PDF]
International Journal of Fertility and Sterility, 2014 Background Poor ovarian response (POR) to gonadotropin stimulation has led to a significant decline in success rate of fertility treatment. The immune system may play an important role in pathophysiology of POR by dysfunctions of cytokines and the ...
Seyed Abdolvahab Taghavi +4 more
doaj
ROLE OF INNATE IMMUNITY FACTORS IN PERIODONTITIS PATHOGENESIS
Журнал микробиологии, эпидемиологии и иммунобиологии, 2016 Chronic generalized periodontitis (CGP) is a disease of periodontium tissues supporting tooth induced by bacteria, that is characterized by the presence of processes of inflammation with destruction ofbone tissue. The knowledge of molecular mechanisms of
L. V. Gankovskaya +3 more
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Blood, 2010 Killer immunoglobulin-like receptors (KIRs) are well-known for binding human leukocyte antigen (HLA) and allowing natural killer (NK) cells to monitor HLA levels on host cells. Unexpectedly, Sivori and colleagues have found that certain KIRs can also bind microbial nucleic acid and deliver it ...
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Advanced Science, EarlyView.Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang +4 more
wiley +1 more source
Advanced Science, EarlyView.Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu +11 more
wiley +1 more source
A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors. [PDF]
PLoS ONE, 2013 Toll-like Receptors (TLR) are phylogenetically conserved transmembrane proteins responsible for detection of pathogens and activation of immune responses in diverse animal species.
Marylene Y Peroval +3 more
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Advanced Science, EarlyView.This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li +12 more
wiley +1 more source
Effects of Separate and Concomitant TLR-2 and TLR-4 Activation in Peripheral Blood Mononuclear Cells of Newborn and Adult Horses. [PDF]
PLoS ONE, 2013 Deficient innate and adaptive immune responses cause newborn mammals to be more susceptible to bacterial infections than adult individuals. Toll-like receptors (TLRs) are known to play a pivotal role in bacterial recognition and subsequent immune ...
Johannes Cornelis Vendrig +2 more
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