Results 21 to 30 of about 183,650 (307)

The cationic liposome CCS/C adjuvant induces immunity to influenza independently of the adaptor protein MyD88

Human Vaccines & Immunotherapeutics, 2020
Traditional non-living vaccines are often least effective in the populations that need them most, such as neonates and elderly adults. Vaccine adjuvants are one approach to boost the immunogenicity of antigens in populations with reduced immunity ...
Orli Even-Or, Shani Avniel-Polak, Yechezkel Barenholz, Gabriel Nussbaum   +3 more
doaj   +1 more source

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis

OncoImmunology, 2017
Exosomes are a class of nanovesicles formed and released through the late endosomal compartment and represent an important mode of intercellular communication. The ability of anticancer chemotherapy to enhance the immunogenic potential of malignant cells
Elisabetta Vulpis, Francesca Cecere, Rosa Molfetta, Alessandra Soriani, Cinzia Fionda, Giovanna Peruzzi, Giulio Caracciolo, Sara Palchetti, Laura Masuelli, Lucilla Simonelli, Ugo D'Oro, Maria Pia Abruzzese, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Rossella Paolini, Marco Cippitelli, Angela Santoni, Alessandra Zingoni   +17 more
doaj   +1 more source

PROSPECTS OF Toll-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS

Медицинская иммунология, 2019
Antiviral research has focused mainly on viral targets. However, cellular targets involved in the viral life cycle and antiviral response are becoming more attractive for research, providing a variety of opportunities for antiviral therapy.
A. A. Nikonova, M. R. Khaitov, R. M. Khaitov   +2 more
doaj   +1 more source

ADMINISTRATION OF BONE MARROW DERIVED MESENCHYMAL STEM CELLS MODULATE TLR EXPRESSION DURING LIVER REGENERATION

Trakya University Journal of Natural Sciences, 2019
Liver cell transplantation is a powerful alternative to orthotopic cell transplantation in the treatment of liver failures. Recently, considerable effort is being channeled to understand the nature and kinetics of directing stem cells to effectively ...
İhsan Gursel, Kamil Can Akçalı, Burcu İnsal, Hande Kocak, Zeynep Tokcaer-keskin   +4 more
doaj   +1 more source

Digitalization of toxicology: improving preclinical to clinical translation

Frontiers in Toxicology
Though the portfolio of medicines that are extending and improving the lives of patients continues to grow, drug discovery and development remains a challenging business on its best day.
Brian R. Berridge, Szczepan W. Baran, Vivek Kumar, Natalie Bratcher-Petersen, Michael Ellis, Chang-Ning Liu, Timothy L. Robertson, Timothy L. Robertson   +7 more
doaj   +1 more source

Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction

, 2019
Small molecule Toll-like receptor-7 and -8 agonists (TLR-7/8a) can be used as vaccine adjuvants to induce CD8 T cell immunity but require formulations that prevent systemic toxicity and focus adjuvant activity in lymphoid tissues.
Geoffrey M. Lynn, Karel Ulbrich (515369), Faezzah Baharom, Gray Kueberuwa (6244223), Faezzah Baharom (4093315), Amy Q. Wang (1395658), Joseph R. Francica (242197), Neeha Zaidi (6244229), Joseph R. Francica, Robert A. Seder, Andrew S. Ishizuka (6244226), Anna Lagová, Nicolas J. Blobel, Nicolas J. Blobel (6244235), Richard Laga, Neeha Zaidi, Ramiro A. Ramirez-Valdez, Anna Lagová (6244220), Andrew S. Ishizuka, Michael Y. Gerner (690623), Richard Laga (1554178), Michael Y. Gerner, Ramiro A. Ramirez-Valdez (6244232), Amy Q. Wang, Geoffrey M. Lynn (6244217), Joseph Leal (3928820), Robert A. Seder (750008), Tomáš Etrych, Tomáš Etrych (1554169), Gray Kueberuwa, Joseph Leal, Karel Ulbrich, Petr Chytil, Petr Chytil (1887454), Leonard W. Seymour, Leonard W. Seymour (9362)   +35 more
core   +1 more source

Inflammaging as the basis of age-associated diseases

Медицинская иммунология, 2020
Aging is one of the most complex biological phenomena that affects all human physiological systems, including the immune system. Immunosenescence is understood as structural and functional changes in both adaptive and innate immunity systems.
O. V. Artemyeva, L. V. Gankovskaya
doaj   +1 more source

Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications

Diabetes, Metabolic Syndrome and Obesity, 2020
Awgichew Shewasinad Yehualashet Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, EthiopiaCorrespondence: Awgichew Shewasinad YehualashetPharmacology and Toxicology Unit ...
Yehualashet AS
doaj  

The effect of Kagocel® on gene expression of Toll-like receptors of innate immunity in THP-1 human monocytes with different levels of differentiation

Биопрепараты: Профилактика, диагностика, лечение, 2021
Kagocel® is used in Russia for the treatment of viral infections. In terms of its chemical structure, Kagocel® active ingredient is a copolymer of gossypol polyphenol and carboxymethylcellulose.
T. M. Sokolova, V. V. Poloskov
doaj   +1 more source

Professional Development: Know Your TLR

, 2019
Have you ever been in a meeting with a supervisor wondering when you will get a chance to speak? Or have you walked away from an interview not knowing much about the candidate because you were talking all the time?
Sanjay Saint, Saint, S, Chopra, V, Vineet Chopra   +3 more
core   +1 more source