Results 81 to 90 of about 300,160 (284)

B Cell Activation in Insulin Resistance and Obesity [PDF]

, 2011
Our group has demonstrated that inflammatory diseases such as type 2 diabetes (DM), inflammatory bowel disease (IBD), and periodontal disease (PD) are associated with altered B cell function that may contribute to disease pathogenesis. B cells were found
Apovian, Caroline, Ganley-Leal, Lisa, Gokce, Noyan, Liang, YanMei, McDonnell, Marie, Mehta, Ankeeta, Zhang, Jeanette   +6 more
core   +1 more source

Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis

Advanced Materials, EarlyView.
This study identifies a “mechano‐epigenetic” checkpoint in which matrix stiffness governs the immune responses of gingival fibroblasts. Using biomimetic hydrogels and human gingival explants, the studies revealed that restoring extracellular matrix stiffness actively suppresses inflammation via non‐canonical NF‐κB signaling and DNA methylation ...
Hardik Makkar, Nghi Tran, Yu‐Chang Chen, Kang I. Ko, Rebecca G. Wells, Kyle H. Vining   +5 more
wiley   +1 more source

Association between polymorphisms of IL33 and IL37 and atopic dermatitis

Медицинская иммунология
Atopic dermatitis (AD) is a chronic recurrent inflammatory disease accompanied by severe itching. One of the leading mechanisms underlying the development of AD is an imbalance of the Th1/Th2 cells immune response, which leads to an increased production ...
O. A. Svitich, O. Yu. Olisova, M. B. Potapova, E. A. Meremianina, N. D. Rasskazova, E. A. Belokopytova, A. A. Solodkova, A. A. Murzina, I. B. Semenova, A. G. Upatova   +9 more
doaj   +1 more source

CD44 Suppresses TLR-Mediated Inflammation [PDF]

The Journal of Immunology, 2008
Abstract The cell adhesion molecule CD44, which is the major hyaluronan receptor, has been implicated in the binding, endocytosis, and metabolism of hyaluronan. Previous studies have revealed that CD44 plays crucial roles in a variety of inflammatory diseases.
Hidetada, Kawana, Hirokazu, Karaki, Morihiro, Higashi, Masaru, Miyazaki, Frank, Hilberg, Motoo, Kitagawa, Kenichi, Harigaya   +6 more
openaire   +2 more sources

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Effect of the organoselenium compound 974zh on the TLR2 and TLR4 gene expression in blood and spleen cells of experimental animals when co-administered with Yersinia pestis EV

Acta Biomedica Scientifica
One of the important directions for increasing the immunogenic properties of vaccine strains against highly dangerous infections is the search for adjuvants that not only stimulate the immunological effectiveness of vaccination, but can also provide a ...
A. B. Pyatidesyatnikova, V. I. Dubrovina, O. V. Yurieva, K. M. Korytov, T. I. Ivanova, V. A. Potapov, M. V. Musalov, S. V. Balakhonov   +7 more
doaj   +1 more source

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

Çeşitli Hastalıklarda Toll Benzeri Reseptörlerin Rolü

Sakarya Tıp Dergisi, 2012
Toll benzeri reseptörler, patojenlerin tanınmasından sorumlu doğal immün reseptörlerdir. İnsanlarda on farklı toll benzeri reseptör tanımlanmıştır. Toll benzeri reseptörler çeşitli hastalıklarda ekzojen ligandlar (bakteriyel, viral ve fungal patojenler ...
Berrak Güven, Murat Can
doaj   +1 more source

Local magnetic moments and electronic transport in closed loop quantum dot systems: a case of quadruple quantum dot ring at and away from equilibrium [PDF]

, 2019
We apply the non-equilibrium functional renormalization group approach treating flow of the electronic self-energies, to describe local magnetic moments formation and electronic transport in a quadruple quantum dot (QQD) ring, coupled to leads, with ...
Katanin, A. A., Protsenko, V. S.
core   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source