Results 171 to 180 of about 63,928 (200)

Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis

Human Immunology, 2012
HSV-1 persistently infects almost 90% of our population; however, only 30% of the infected subjects suffer from recurrent herpes lesions, most frequently herpes labialis (HL). We hypothesized that variations in toll-like receptor (TLR) functions might contribute to HL susceptibility.
Chin-An, Yang, Martin J, Raftery, Lutz, Hamann, Manuel, Guerreiro, Gerald, Grütz, Doreen, Haase, Nadine, Unterwalder, Günther, Schönrich, Ralf R, Schumann, Hans-Dieter, Volk, Carmen, Scheibenbogen   +10 more
openaire   +2 more sources

Antiviral responses induced by the TLR3 pathway

Reviews in Medical Virology, 2011
AbstractAntiviral responses are successively induced in virus‐infected animals, and include primary innate immune responses such as type I interferon (IFN) and cytokine production, secondary natural killer (NK) cell responses, and final cytotoxic T lymphocyte (CTL) responses and antibody production.
Misako, Matsumoto, Hiroyuki, Oshiumi, Tsukasa, Seya   +2 more
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The molecular structure of the TLR3 extracellular domain

Journal of Endotoxin Research, 2006
Toll-like receptors (TLRs), type I integral membrane receptors, recognize pathogen associated molecular patterns (PAMPs). PAMP recognition occurs via the N-terminal ectodomain (ECD) which initiates an inflammatory response that is mediated by the C-terminal cytosolic signaling domain.
Jessica K, Bell, Istvan, Botos, Pamela R, Hall, Janine, Askins, Joseph, Shiloach, David R, Davies, David M, Segal   +6 more
openaire   +2 more sources

TLR3 Tolls for dsRNA

Science Signaling, 2001
Members of the Toll-like receptor (TLR) family appear to recognize molecular patterns found on pathogens. Alexopoulou et al. have found that double-stranded RNA (dsRNA), which can be associate with viral infection, is recognized by TLR3. DsRNA-treated HEK293 cells that expressed TLR3 showed increased activity of the
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The dual role of TLR3 in metastatic cell line

Clinical & Experimental Metastasis, 2011
Toll-like receptors (TLRs) are members of transmembrane proteins that recognize conserved molecular motifs of viral and bacterial origin and initiate innate immune response. As the role of TLRs in tumors cells is still not clear, our aim was to investigate the role of TLR3 in primary tumor and metastatic cells (SW480, SW620, FaDu and Detroit 562).
Pavelić, Jasminka, Matijević Glavan, Tanja   +1 more
openaire   +2 more sources

TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

Science, 2007
Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural ecosystems is unknown. We report a dominant-negative TLR3 allele in otherwise healthy children with herpes simplex virus 1 (HSV-1) encephalitis.
Zhang, Shen-Ying, Jouanguy, Emmanuelle, Ugolini, Sophie, Smahi, Asma, Elain, Gaëlle, Romero, Pedro, Segal, David, Sancho-Shimizu, Vanessa, Lorenzo, Lazaro, Puel, Anne, Picard, Capucine, Chapgier, Ariane, Plancoulaine, Sabine, Titeux, Matthias, Cognet, Céline, von Bernuth, Horst, Ku, Cheng-Lung, Casrouge, Armanda, Zhang, Xin-Xin, Barreiro, Luis, Leonard, Joshua, Hamilton, Claire, Lebon, Pierre, Héron, Bénédicte, Vallée, Louis, Quintana-Murci, Lluis, Hovnanian, Alain, Rozenberg, Flore, Vivier, Eric, Geissmann, Frédéric, Tardieu, Marc, Abel, Laurent, Casanova, Jean-Laurent   +32 more
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TLR3 deficiency increases voluntary alcohol consumption

NeuroReport, 2016
Toll-like receptors (TLRs) are innate immunity-related receptors. Many studies have indicated the involvement of TLRs in neurophysiology and neuropathology. One study showed that TLR3 regulates hippocampal memory and is highly expressed in the mesolimbic dopamine system, suggesting that TLR3 signaling may regulate alcohol consumption. The present study
Yujin, Jang, Min Hee, Lee, Jong-Hwan, Park, Seung-Yun, Han, Dong Kwan, Kim   +4 more
openaire   +2 more sources

Investigating the TLR3 Signaling Dynamics

2013
Along with TLR-7, -8, and -9, TLR3 is an intracellular member of the Toll-like receptor (TLR) superfamily (see Chap. 3). It plays a crucial role in the mammalian innate immune response against viral attacks by recognizing double-stranded RNA (dsRNA) or its synthetic analogue polyinosinic-polycytidylic acid (poly (I:C)).
openaire   +1 more source

TLR3 Agonists as Immunotherapeutic Agents

Immunotherapy, 2010
Christopher F, Nicodemus, Jonathan S, Berek   +1 more
openaire   +2 more sources

Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses

Journal of Zhejiang University: Science B, 2021
Hua-shan Yi
exaly