Results 1 to 10 of about 352,273 (289)

Roles of Toll-Like Receptor 3 in Human Tumors [PDF]

Frontiers in Immunology, 2021
Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons ...
Xin Zheng, Song Li, Hui Yang
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Toll-like receptor 3: a double-edged sword [PDF]

Biomarker Research
The discovery of Toll-like receptors (TLRs) and their role in dendritic cells earned the Nobel Prize for 2011 because TLRs profoundly enhanced our understanding of the immune system.
Marvin L Hsieh, Daisuke Nishizaki, Jacob J Adashek, Shumei Kato, Razelle Kurzrock   +4 more
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Toll-Like receptor 3 genetic polymorphism in dengue encephalitis [PDF]

Journal of Family Medicine and Primary Care
Context: Dengue is one of the important vector-borne viral diseases affecting humans with diverse manifestations. Toll-like receptors (TLR) are pattern recognition receptors and play an important role in innate immunity against microbes.
Rajesh Verma, Atul K. Pandey, Rajarshi Chakraborty, Shantanu Prakash, Amita Jain   +4 more
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Anti‐pruritic effect of isothiocyanates: Potential involvement of toll‐like receptor 3 signaling [PDF]

Pharmacology Research & Perspectives, 2022
The innate immune system has an emerging role as a mediator of neuro‐immune communication and a therapeutic target for itch. Toll‐like receptor 3 (TLR3) plays an important role in itch, as shown in TLR3 knock‐out mice.
Masaki Moriyama, Mitsuhiro Konno, Kanako Serizawa, Natsumi Yuzawa, Yuki Majima, Ikuo Hayashi, Tomohiko Suzuki, Mie Kainoh   +7 more
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Toll-like receptor 3 activation promotes joint degeneration in osteoarthritis [PDF]

Cell Death and Disease, 2022
Osteoarthritis (OA) is characterized by cartilage degradation that is induced by inflammation. Sterile inflammation can be caused by damage-associated molecular patterns that are released by chondrocytes and activate pattern recognition receptors.
Josef Stolberg-Stolberg, Annika Boettcher, Meike Sambale, Sina Stuecker, Joanna Sherwood, Michael Raschke, Thomas Pap, Jessica Bertrand   +7 more
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Avian Toll-like receptor 3 isoforms and evaluation of Toll-like receptor 3–mediated immune responses using knockout quail fibroblast cells [PDF]

Poultry Science, 2020
Toll-like receptor 3 (TLR3) induces host innate immune response on recognition of viral double-stranded RNA (dsRNA). Although several studies of avian TLR3 have been reported, none of these studies used a gene knockout (KO) model to directly assess its ...
Mahesh KC, John M. Ngunjiri, Joonbum Lee, Jinsoo Ahn, Mohamed Elaish, Amir Ghorbani, Michael E.C. Abundo, Kichoon Lee, Chang-Won Lee   +8 more
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Extracellular RNA Induces Neutrophil Recruitment Via Toll‐Like Receptor 3 During Venous Thrombosis After Vascular Injury [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Venous thromboembolism is associated with endothelial cell activation that contributes to the inflammation‐dependent activation of the coagulation system. Cellular damage is associated with the release of different species of extracellular RNA
Maria Y. Najem, Ryan N. Rys, Sandrine Laurance, François‐René Bertin, Virginie Gourdou‐Latyszenok, Lénaïck Gourhant, Lauriane Le Gall, Rozenn Le Corre, Francis Couturaud, Mark D. Blostein, Catherine A. Lemarié   +10 more
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TL-532, a novel specific Toll-like receptor 3 agonist rationally designed for targeting cancers: discovery process and biological characterization [PDF]

Microbial Cell, 2023
Toll-like receptor 3 (TLR3) is an innate immune receptor that recognizes double-stranded RNA (dsRNA) and induces inflammation in immune and normal cells to initiate anti-microbial responses. TLR3 acts also as a death receptor only in cancer cells but not
Sylvain Thierry, Sarah Maadadi, Aurore Berton, Laura Dimier, Clémence Perret, Nelly Vey, Saïd Ourfali, Mathilde Saccas, Solène Caron, Mathilde Boucard-Jourdin, Marc Colombel, Bettina Werle, Marc Bonnin   +12 more
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Toll-like receptor 3 signaling attenuated colitis-associated cancer development in mice [PDF]

Scientific Reports
Inflammatory bowel disease is associated with a high risk of colitis-associated cancer (CAC). We evaluated the role of TLR3 in CAC using a murine model.
Kee Young Chung, Seulji Kim, Hee Tae Yoon, So Hyun Kwon, Hyun Sun Park, Jong Pil Im, Joo Sung Kim, Ji Won Kim, Yoo Min Han, Seong-Joon Koh   +9 more
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Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy [PDF]

Acta Pharmaceutica Sinica B, 2022
Toll-like receptor 3 (TLR3), as an important pattern recognition receptor (PRR), dominates the innate and adaptive immunity regulating many acute and chronic inflammatory diseases.
Xiaohong Cen, Baoqu Wang, Yuqing Liang, Yanlin Chen, Yu Xiao, Shaohua Du, Kutty Selva Nandakumar, Hang Yin, Shuwen Liu, Kui Cheng   +9 more
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