Results 41 to 50 of about 235,198 (285)

Toll-Like Receptor 3 Mediates a More Potent Antiviral Response Than Toll-Like Receptor 4 [PDF]

The Journal of Immunology, 2003
Abstract We have recently described an IFN regulatory factor 3-mediated antiviral gene program that is induced by both Toll-like receptor (TLR)3 and TLR4 ligands. In our current study, we show that activation of IFN/viral response gene expression in primary macrophage cells is stronger and prolonged with TLR3 stimulation compared with
Sean E, Doyle, Ryan, O'Connell, Sagar A, Vaidya, Edward K, Chow, Kathleen, Yee, Genhong, Cheng   +5 more
openaire   +2 more sources

Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells

Journal of Biomedical Science, 2011
Background Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system.
Du Yung-Ying, Wu Chia-Ling, Huang Chao-Cheng, Chuang Hui-Ching, Chuang Jiin-Haur, Kung Mei-Lang, Chen Chih-Hao, Chen San-Cher, Tai Ming-Hong   +8 more
doaj   +1 more source

Expression and functionality of Toll‐like receptor 3 in the megakaryocytic lineage [PDF]

Journal of Thrombosis and Haemostasis, 2015
In addition to their key role in hemostasis, platelets and megakaryocytes regulate immune and inflammatory responses, in part through their expression of Toll-like receptors (TLRs). Among the TLRs, TLR3 recognizes dsRNA associated with viral infection. Thrombocytopenia is a frequent complication of viral infection.
D'Atri, Lina Paola, Etulain, Julia, Rivadeneyra, Leonardo, Lapponi, María José, Centurion, M., Cheng, K., Yin, H., Schattner, Mirta Ana   +7 more
openaire   +3 more sources

The dsRNA binding site of human Toll-like receptor 3 [PDF]

Proceedings of the National Academy of Sciences, 2006
Pathogen recognition by Toll-like receptors (TLRs) initiates innate immune responses that are essential for inhibiting pathogen dissemination and for the development of acquired immunity. The TLRs recognize pathogens with their N-terminal ectodomains (ECD), but the molecular basis for this recognition is not known.
Jessica K, Bell, Janine, Askins, Pamela R, Hall, David R, Davies, David M, Segal   +4 more
openaire   +2 more sources

Association Between Single-Nucleotide Polymorphisms in <i>Toll-like Receptor 3</i> (<i>tlr3</i>), <i>tlr7</i>, <i>tlr8</i> and <i>tirap</i> Genes with Severe Symptoms in Children Presenting COVID-19. [PDF]

Viruses
Andrade AS, Bentes AA, Diniz LM, Carvalho SH, Kroon EG, Campos MA.   +5 more
europepmc   +3 more sources

Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension [PDF]

American Journal of Respiratory and Critical Care Medicine, 2019
Abstract Rationale Pulmonary arterial hypertension (PAH) is characterized by vascular cell proliferation and endothelial cell apoptosis. TLR3 (Toll-like receptor 3) is a receptor for double-stranded RNA and has been recently implicated in vascular protection.
Farkas, D., Thompson, A.A.R., Bhagwani, A.R., Hultman, S., Ji, H., Kotha, N., Farr, G., Arnold, N.D, Braithwaite, A., Casbolt, H., Cole, J.E., Sabroe, I., Monaco, C., Cool, C.D., Goncharova, E.A., Lawrie, A., Farkas, L.   +16 more
openaire   +6 more sources

Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy

Frontiers in Immunology, 2017
Pattern recognition receptors (PRRs) play a crucial role in the innate immune system and contribute to host defense against microbial infection. PRR-mediated antimicrobial signals provide robust type-I IFN/cytokine production and trigger inflammation ...
Misako Matsumoto, Yohei Takeda, Megumi Tatematsu, Tsukasa Seya   +3 more
doaj   +1 more source

Staphylococcus aureus increases Prostaglandin E2 secretion in cow neutrophils by activating TLR2, TLR4, and NLRP3 inflammasome signaling pathways

Frontiers in Microbiology, 2023
IntroductionIn clinical settings, dairy cows are often attacked by pathogenic bacteria after delivery, especially Staphylococcus aureus (S. aureus). Neutrophils have long been regarded as essential for host defense against S. aureus.
Kai Zhang, Kai Zhang, Yan Jia, Yan Jia, Yinghong Qian, Xueying Jiang, Xueying Jiang, Shuangyi Zhang, Shuangyi Zhang, Bo Liu, Bo Liu, Jinshan Cao, Jinshan Cao, Yongli Song, Wei Mao, Wei Mao   +15 more
doaj   +1 more source

Clostridium butyricum Helps to Alleviate Inflammation in Weaned Piglets Challenged With Enterotoxigenic Escherichia coli K88

Frontiers in Veterinary Science, 2021
Background: Whether the probiotic Clostridium butyricum (CB) alleviates enterotoxigenic Escherichia coli (ETEC) K88-induced inflammation by regulating the activation of the toll-like receptor (TLR) signaling pathway is not clear, thus, we carried out ...
Haihua Li, Xuejiao Liu, Zhiyuan Shang, Jiayun Qiao   +3 more
doaj   +1 more source

LncRNA CRNDE triggers inflammation through the TLR3-NF-κB-Cytokine signaling pathway

Tumor Biology, 2017
Colorectal neoplasia differentially expressed (CRNDE), an oncogene, is highly expressed in many tumor cells and affects cellular proliferation, migration, invasion, and apoptosis. Its function and mechanism of action is a research hotspot. In this study,
Haowen Li, Qi Li, Tao Guo, Wenyan He, Chengya Dong, Yajie Wang   +5 more
doaj   +1 more source