Results 61 to 70 of about 352,273 (289)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Pattern-recognition receptors in endometriosis: A narrative review

Frontiers in Immunology, 2023
Endometriosis is closely associated with ectopic focal inflammation and immunosuppressive microenvironment. Multiple types of pattern recognition receptors (PRRs) are present in the innate immune system, which are able to detect pathogen-associated ...
Bao Guo, Jia hua Chen, Jun hui Zhang, Yuan Fang, Xiao jing Liu, Jing Zhang, Hai qing Zhu, Lei Zhan   +7 more
doaj   +1 more source

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. [PDF]

, 2013
BackgroundSpinal Toll-like receptors (TLRs) and signaling intermediaries have been implicated in persistent pain states. We examined the roles of two major TLR signaling pathways and selected TLRs in a mononeuropathic allodynia.MethodsL5 spinal nerve ...
A Ledeboer, AI de la Llave-Rincon, AL Oaklander, AS Jaggi, BJ Marsh, C Erridge, C Fernandez-de-las-Penas, C Fernandez-de-las-Penas, CA Christianson, CC Bowman, CF Kim, CI Svensson, CR Stewart, CS Jack, D Kim, D Kim, F Kozin, F Marchand, FY Tanga, H Cao, H Hacker, H Hashizume, H Tsujino, H Yanai, I Bettoni, J Mika, J Zhang, JA DeLeo, JA Stokes, JA Stokes, Jennifer A Stokes, JL Hylden, JM Chung, Jonathan Cheung, K Hoebe, K Honda, K Hoshino, K Kariko, KA Cavassani, Kelly Eddinger, KH Konopka, L Cao, L Nicotra, L Znaor, LA O’Neill, LA Panagio, LH Guo, M Bsibsi, M Calvo, M Chacur, M Hossaini, M Koltzenburg, M Yamamoto, Maripat Corr, MR Hutchinson, MR Hutchinson, NE Saade, O Adachi, O Saito, O Takeuchi, P Hu, P Hu, Q Xu, Q Zhang, R Wang, RE Sorge, RG Chen, RG Zanon, S Akira, S Akira, S Hosmane, S Lehnardt, S Nadeau, S Pu, S Rivest, S Sakaguchi, SR Chaplan, SW Mitchell, T Kawai, T King, T Liu, T Shichita, T Tanaka, Tony L Yaksh, TW Vanderah, V Huge, V Raghavendra, V Raghavendra, XY Hua, Y Ohmichi, YR Wen   +90 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Toll-like receptor 3 modulates the behavioral effects of cocaine in mice

Journal of Neuroinflammation, 2018
Background The nucleus accumbens in the midbrain dopamine limbic system plays a key role in cocaine addiction. Toll-like receptors (TLRs) are important pattern-recognition receptors (PPRs) in the innate immune system that are also involved in drug ...
Ruiming Zhu, Qian Bu, Dengqi Fu, Xue Shao, Linhong Jiang, Wei Guo, Bo Chen, Bin Liu, Zhengtao Hu, Jingwei Tian, Yinglan Zhao, Xiaobo Cen   +11 more
doaj   +1 more source

Toll-like receptor 3 signaling attenuates liver regeneration # [PDF]

Hepatology, 2009
Abstract The current model for liver regeneration suggests that cell damage triggers Toll-like receptor (TLR) signaling via MyD88, leading to the induction of nuclear factor κB (NF-κB) and secretion of inflammatory cytokines that in turn prime liver regeneration.
Elina, Zorde-Khvalevsky, Rinat, Abramovitch, Hila, Barash, Irit, Spivak-Pohis, Ludmila, Rivkin, Jacob, Rachmilewitz, Eithan, Galun, Hilla, Giladi   +7 more
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model

, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core   +2 more sources

Drift, not selection, shapes toll-like receptor variation among oceanic island populations [PDF]

, 2015
Understanding the relative role of different evolutionary forces in shaping the level and distribution of functional genetic diversity among natural populations is a key issue in evolutionary and conservation biology.
Acevedo-Whitehouse, Aguilar, Akira, Alcaide, Areal, Basu, Belvin, Betrán, Bollmer, Cabe, Chen, Cramp, Downing, Ekblom, England, Excoffier, Fornůsková, Frankham, Frankham, Garza, Gautschi, Girard, Goslee, Grueber, Grueber, Grueber, Grueber, Hall, Hartl, Hartmann, Hedrick, Hudson, Hughes, Illera, Jensen, Jiggins, Kalinowski, Keestra, Klein, Kryazhimskiy, Librado, Manly, Mikami, Miller, Misch, Murrell, Murrell, Nakajima, Ohta, Oliver, Outlaw, Piertney, Poltorak, Pond, Pond, Quéméré, R Development Core Team, Raymond, Richardson, Roach, Schröder, Sommer, Spurgin, Spurgin, Spurgin, Spurgin, Stephens, Sutton, Takeuchi, Tamura, Teacher, Trowsdale, Tschirren, Tschirren, Turner, Voelker, Winternitz, Wlasiuk, Yoneyama   +78 more
core   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source