Results 31 to 40 of about 352,273 (289)

Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat

Molecular Pain, 2011
Background Mechanisms underlying pain in chronic pancreatitis (CP) are incompletely understood. Our previous data showed that astrocytes were actively involved. However, it was unclear how astrocytic activation was induced in CP conditions.
Feng Quan-Xing, Liao Yong-Hui, Qian Nian-Song, Tang Yu, Dou Ke-Feng, Tao Kai-Shan   +5 more
doaj   +1 more source

Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells [PDF]

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
Dansako, Hiromichi, Hu, Fengyu, Kato, Nobuyuki, Lemon, Stanley M., McGivern, David R., Welsch, Christoph, Yamane, Daisuke   +6 more
core   +4 more sources

Expression and functionality of Toll‐like receptor 3 in the megakaryocytic lineage [PDF]

Journal of Thrombosis and Haemostasis, 2015
In addition to their key role in hemostasis, platelets and megakaryocytes regulate immune and inflammatory responses, in part through their expression of Toll-like receptors (TLRs). Among the TLRs, TLR3 recognizes dsRNA associated with viral infection. Thrombocytopenia is a frequent complication of viral infection.
D'Atri, Lina Paola, Etulain, Julia, Rivadeneyra, Leonardo, Lapponi, María José, Centurion, M., Cheng, K., Yin, H., Schattner, Mirta Ana   +7 more
openaire   +3 more sources

The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes [PDF]

, 2014
Peer reviewedPublisher ...
Berry, Susan, Brookes, Heather, Bryant, Clare E, Drew, Janice, El-Omar, Emad M, Gay, Nick J, Hold, Georgina L, Mayer, Claus, Saunders, Karin A   +8 more
core   +8 more sources

Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations:A Randomized Controlled Study [PDF]

, 2017
BACKGROUND: Human rhinoviruses (HRVs) commonly precipitate asthma exacerbations. Toll-like receptor 3, an innate pattern recognition receptor, is triggered by HRV, driving inflammation that can worsen asthma.
Backer, Vibeke, Baribaud, Frédéric, Barnathan, Elliot S., Branigan, Patrick, Del Vecchio, Alfred M., Diamant, Zuzana, Eich, Andreas, Flavin, Susan, Gern, James E., Gordon, Robert, Halperin, Scott A., Herzmann, Christian, Johnston, Sebastian L., Lipworth, Brian J., Loza, Mathew J., Lutter, Rene, Mensinga, Tjeert T., Proud, David, San Mateo, Lani, Silkoff, Philip E., Singh, Dave, Sterk, Peter J., Turner, Ronald B.   +22 more
core   +3 more sources

Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]

, 2009
U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
C. D. Sadik, M. Bachmann, J. Pfeilschifter, H. Muhl, Busch, Will, Hoet, Lovgren, Hoffman, Casciola-Rosen, Biggiogera, Malmegrim, Dieker, Rosen, Hof, Vandivier, Bowie, Gantier, Schr  der, Matsumoto, Honda, Yoneyama, Schleimer, M  ller, Sexton, Monks, Dow, Colin, O'neill, Schreiber, Schafer, Taniguchi, Colonna, Tamura, Hemmi, M  hl, Reddy, Sioud, Degen, Sturchier, Gowen, Nagai, Pirher, Platanias, Grumbach, Yu, Chung, Krysko, King, Akbar, Vervoordeldonk, Nikolaus, Wirtz, Hemmer, Katakura, Sel, Fadok, Voll, Moller, O'Garra   +59 more
core   +1 more source

Red blood cell alloimmunization is influenced by the delay between Toll-like receptor agonist injection and transfusion

Haematologica, 2016
Murine models of red blood cell transfusion show that inflammation associated with viruses or methylated DNA promotes red blood cell alloimmunization.
Rahma Elayeb, Marie Tamagne, Philippe Bierling, France Noizat-Pirenne, Benoît Vingert   +4 more
doaj   +1 more source

Toll-Like Receptor 3 in Solid Cancer and Therapy Resistance. [PDF]

Cancers (Basel), 2020
Toll-like receptor 3 (TLR3) is a member of the TLR family, which has been extensively studied for its antiviral function. It is highly expressed in the endosomes of antigen-presenting immune cells and epithelial cells. TLR3 binds specifically double-strand RNAs (dsRNAs), leading to the activation of mainly two downstream pathways: the phosphorylation ...
Muresan XM, Bouchal J, Culig Z, Souček K.   +3 more
europepmc   +4 more sources

The dsRNA binding site of human Toll-like receptor 3 [PDF]

Proceedings of the National Academy of Sciences, 2006
Pathogen recognition by Toll-like receptors (TLRs) initiates innate immune responses that are essential for inhibiting pathogen dissemination and for the development of acquired immunity. The TLRs recognize pathogens with their N-terminal ectodomains (ECD), but the molecular basis for this recognition is not known.
Jessica K, Bell, Janine, Askins, Pamela R, Hall, David R, Davies, David M, Segal   +4 more
openaire   +2 more sources

Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells

Journal of Biomedical Science, 2011
Background Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system.
Du Yung-Ying, Wu Chia-Ling, Huang Chao-Cheng, Chuang Hui-Ching, Chuang Jiin-Haur, Kung Mei-Lang, Chen Chih-Hao, Chen San-Cher, Tai Ming-Hong   +8 more
doaj   +1 more source