Results 31 to 40 of about 235,198 (285)
Predicting novel features of toll-like receptor 3 signaling in macrophages. [PDF]
PLoS ONE, 2009 The Toll-like receptor (TLR) 3 plays a critical role in mammalian innate immune response against viral attacks by recognizing double-stranded RNA (dsRNA) or its synthetic analog polyinosinic-polycytidylic acid (poly (IratioC)).
Mohamed Helmy +5 more
doaj +1 more source
Modeling of the Toll‐like receptor 3 and a putative Toll‐like receptor 3 antagonist encoded by the African swine fever virus [PDF]
Protein Science, 2011 AbstractAfrican swine fever virus (ASFV) is a large double‐stranded DNA virus responsible for a lethal pig disease, to which no vaccine has ever been obtained. Its genome encodes a number of proteins involved in virus survival and transmission in its hosts, in particular proteins that inhibit signaling pathways in infected macrophages and, thus ...
Henriques, Elsa S +5 more
openaire +2 more sources
Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity. [PDF]
PLoS ONE, 2013 Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxicity. Herein, we hypothesize that TLR3 activation significantly contributed to APAP-induced liver injury.
Karen A Cavassani +13 more
doaj +1 more source
Frontiers in Immunology, 2022 Risk stratification for cytomegalovirus (CMV) infection after kidney transplantation (KT) remains to be determined. Since endosomal toll-like receptors (TLRs) are involved in viral sensing, we investigated the impact of common single-nucleotide ...
Natalia Redondo +25 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Chikungunya virus (CHIKV) is the etiological agent of chikungunya fever (CHIKF), a self-limiting disease characterized by myalgia and severe acute or chronic arthralgia. CHIKF is associated with immunopathology and high levels of pro-inflammatory factors.
Juan Felipe Valdés-López +2 more
doaj +1 more source
mRNA Is an Endogenous Ligand for Toll-like Receptor 3 [PDF]
Journal of Biological Chemistry, 2004 Toll-like receptors (TLRs) are the basic signaling receptors of the innate immune system. They are activated by molecules associated with pathogens or injured host cells and tissue. TLR3 has been shown to respond to double stranded (ds) RNA, a replication intermediary for many viruses.
Katalin, Karikó +4 more
openaire +2 more sources
The Toll-like receptor 3:dsRNA signaling complex [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2009 Toll-like receptors (TLRs) recognize conserved molecular patterns in invading pathogens and trigger innate immune responses. TLR3 recognizes dsRNA, a molecular signature of most viruses via its ectodomain (ECD). The TLR3-ECD structure consists of a 23 turn coil bent into the shape of a horseshoe with specialized domains capping the N and C-terminal ...
Istvan, Botos +4 more
openaire +2 more sources
Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat
Molecular Pain, 2011 Background Mechanisms underlying pain in chronic pancreatitis (CP) are incompletely understood. Our previous data showed that astrocytes were actively involved. However, it was unclear how astrocytic activation was induced in CP conditions.
Feng Quan-Xing +5 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2022 Toll-like receptor 3 (TLR3), as an important pattern recognition receptor (PRR), dominates the innate and adaptive immunity regulating many acute and chronic inflammatory diseases.
Xiaohong Cen +9 more
doaj +1 more source
Haematologica, 2016 Murine models of red blood cell transfusion show that inflammation associated with viruses or methylated DNA promotes red blood cell alloimmunization.
Rahma Elayeb +4 more
doaj +1 more source