Toll-Like Receptor 3 in Liver Diseases [PDF]
Gastroenterology Research and Practice, 2010 Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity.
Shi Yin, Bin Gao
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Placental Toll-like receptor 3 and Toll-like receptor 7/8 activation contributes to preeclampsia in humans and mice. [PDF]
PLoS ONE, 2012 Preeclampsia (PE) is a pregnancy-specific hypertensive syndrome characterized by excessive maternal immune system activation, inflammation, and endothelial dysfunction.
Piyali Chatterjee +10 more
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Role of Toll-Like Receptor 3 Gene Polymorphisms in Preeclampsia [PDF]
Cellular Physiology and Biochemistry, 2015 Background/Aims: Accumulating evidence suggests that an excessive maternal systemic inflammatory response to pregnancy with exaggerated activation of the innate immune system plays a critical role in the development of preeclampsia (PE).
Aiping Chen +5 more
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Toll‐Like Receptor 3: A Link between Toll‐Like Receptor, Interferon and Viruses [PDF]
Microbiology and Immunology, 2004 AbstractProduction of type I interferon (IFN‐α/β) by virus‐infected cells is the central event in their antiviral immune responses. In mammalian cells, IFN‐α/β gene transcription is induced through distinct signaling pathways by viral infection or by treatment with double‐stranded (ds) RNA, which is an intermediate of virus replication.
Misako, Matsumoto +3 more
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Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression [PDF]
, 2009 The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders.
Aghabarari, A. +8 more
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Polyinosinic Acid Is a Ligand for Toll-like Receptor 3 [PDF]
Journal of Biological Chemistry, 2007 Innate immune responses are critical in controlling viral infections. Viral proteins and nucleic acids have been shown to be recognized by pattern recognition receptors of the Toll-like receptor (TLR) family, triggering downstream signaling cascades that lead to cellular activation and cytokine production.
Marshall-Clarke, Stuart +7 more
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The Role of MEG3 in the Activation of Toll Like Receptor 3 in Prostate Cancer Cells
Sakarya Tıp Dergisi, 2021 Objective: Prostate cancer accounts for approximately 10% of new cases diagnosed in men worldwide. Toll like receptors (TLRs) play a crucial role in the progression of cancer.
Gamze Güney Eskiler +5 more
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PM2.5 increases mouse blood pressure by activating toll-like receptor 3
Ecotoxicology and Environmental Safety, 2022 Background and aims: Plenty of literature has documented that fine particulate matter (PM2.5) exposure is related to blood pressure (BP) elevation. Vascular dysfunction is the initiation of cardiovascular diseases, such as hypertension.
Jinna Zhang +10 more
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Modeling of the Toll‐like receptor 3 and a putative Toll‐like receptor 3 antagonist encoded by the African swine fever virus [PDF]
Protein Science, 2011 AbstractAfrican swine fever virus (ASFV) is a large double‐stranded DNA virus responsible for a lethal pig disease, to which no vaccine has ever been obtained. Its genome encodes a number of proteins involved in virus survival and transmission in its hosts, in particular proteins that inhibit signaling pathways in infected macrophages and, thus ...
Henriques, Elsa S +5 more
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The Toll-like receptor 3:dsRNA signaling complex [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2009 Toll-like receptors (TLRs) recognize conserved molecular patterns in invading pathogens and trigger innate immune responses. TLR3 recognizes dsRNA, a molecular signature of most viruses via its ectodomain (ECD). The TLR3-ECD structure consists of a 23 turn coil bent into the shape of a horseshoe with specialized domains capping the N and C-terminal ...
Istvan, Botos +4 more
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