Results 171 to 180 of about 274,305 (384)

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis

Acta Pharmacologica Sinica, 2021
Sainan Chen, Ying Tan, Xiaochan Xiao, Qian Li, Qi Wu, You-you Peng, Jun Ren, Maolong Dong   +7 more
semanticscholar   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer [PDF]

, 2018
Matthew S. Block, Robert A. Vierkant, Peter Rambau, Stacey J. Winham, Philipp Wagner, Nadia Traficante, Aleksandra Tołoczko, Daniel Guimarães Tiezzi, Florin‐Andrei Taran, Hans‐Peter Sinn, Weiva Sieh, Raghwa Sharma, Joseph H. Rothstein, Teresa Ramón y Cajal, Luis Paz‐Ares, Oleg Oszurek, Sandra Oršulić, Roberta B. Ness, Gregg Nelson, Francesmary Modugno, Janusz Menkiszak, Valerie McGuire, Bryan M. McCauley, Marie Mack, Jan Lubiński, Teri A. Longacre, Zheng Li, Jenny Lester, Catherine J. Kennedy, Kimberly R. Kalli, Audrey Jung, Sharon E. Johnatty, Mercedes Jimenez‐Liñan, Allan Jensen, Maria P. Intermaggio, Jillian A. Hung, Esther Herpel, Brenda Y. Hernandez, Andreas D. Hartkopf, Paul R. Harnett, Prafull Ghatage, Jose Maria Garcia-Bueno, Bo Gao, Sián Fereday, Ursula Eilber, Robert P. Edwards, Christiani Bisinoto de Sousa, Jurandyr Moreira de Andrade, Anita Chudecka-Głaz, Georgia Chenevix‐Trench, Alicia Cazorla, Sara Y. Brucker, Jennifer Alsop, Alice S. Whittemore, Helen Steed, Annette Staebler, Kirsten B. Moysich, Usha Menon, Jennifer M. Koziak, Stefan Kommoss, Susanne K. Kjær, Linda E. Kelemen, Beth Y. Karlan, David G. Huntsman, Estrid Høgdall, Jacek Gronwald, Marc T. Goodman, C. Blake Gilks, María J. García, Peter A. Fasching, Anna de Fazio, Suha Deen, Jenny Chang‐Claude, Francisco José Cândido dos Reis, Ian Campbell, James D. Brenton, David D.L. Bowtell, Javier Benı́tez, Paul D.P. Pharoah, Martin Köbel, Susan J. Ramus, Ellen L. Goode, David D.L. Bowtell, Georgia Chenevix‐Trench, A. Green, Penelope M. Webb, Anna DeFazio, Dorota M. Gertig, Nadia Traficante, Sián Fereday, S. Moore, Jillian A. Hung, K.R. Harrap, T. Sadkowsky, Nirmala Pandeya, M. Malt, A. Mellon, R. Paul Robertson, T. Vanden Bergh, Marsha Jones   +99 more
openalex   +1 more source

Near‐Infrared Switch‐Driven Macrophage Dynamically Reprogramming for Anti‐Infection and Tissue Healing on Polyetheretherketone Implants

Advanced Science, EarlyView.
This study develops a Mg‐H‐SPEEK implant with NIR‐switchable immunomodulatory properties. Under NIR, it promotes M1 macrophages for antibacterial action; without NIR, it induces M2 reprogramming to enhance tissue healing. This dual‐function material offers a smart strategy for reducing infection and improving integration in percutaneous implants ...
Yinghao Wu, Shuaiqi Jiang, Jibing He, Ji Tan, Junjie Zhou, Zhipeng Zou, Jiaxing Wang, Jia Jiang, Xuanyong Liu, Xiaochun Peng   +9 more
wiley   +1 more source

The role of acetylation in TLR4‐mediated innate immune responses [PDF]

, 2013
Xiaolan Hu, Yingnian Yu, Y. Eugene Chin, Qiang Xia   +3 more
openalex   +1 more source

microRNA-630 Regulates Underglycosylated IgA1 Production in the Tonsils by Targeting TLR4 in IgA Nephropathy [PDF]

, 2020
Chan Liu, Muyao Ye, Wenzhe Yan, Xiaofei Peng, Liyu He, Youming Peng   +5 more
openalex   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

Advanced Science, EarlyView.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden, Craig J McClain, Zhongbin Deng   +11 more
wiley   +1 more source

Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children [PDF]

, 2020
Elina Tenhu, Johanna Teräsjärvi, Manuel Leite Cruzeiro, Okko Savonius, Emilie Rugemalira, Irmeli Roine, Qiushui He, Tuula Pelkonen   +7 more
openalex   +1 more source