Results 371 to 380 of about 262,724 (386)

TLR4-Based Immunotherapeutics in Cancer: A Review of the Achievements and Shortcomings.

Molecular Pharmaceutics, 2018
Toll-like Receptor 4 (TLR4) agonists have had a long journey in the field of cancer immunotherapy. Nevertheless, despite the remarkable number of the TLR4 ligands that have gone through various preclinical and clinical stages, only two (Bacillus Calmette-
Maryam A. Shetab Boushehri, A. Lamprecht
semanticscholar   +1 more source

Cigarette Smoke Upregulates TLR4 Expression and Enhances TLR4 Mediated Responses

2006
A key component of the innate defence mecbanisms against infections is represented by the tolllike receptor (TLR) family. We explored the role played by TLR4 in the pathogenesis of chronic obstructive pulmonary disease (COPD). We first assessed TLR4 expression by immunohystochemistry in surgical specimens from current and former smoker COPDs, from ...
PACE E, FERRARO M, MINERVINI MI, CHIAPPARA G, SIENA L, PIPITONE L, MELIS MR, MONTALBANO AM, BONSIGNORE MR, BELLIA V, BONSIGNORE G, GJOMARKAJ M   +11 more
openaire   +3 more sources

A Tenacious Hold on TLR4

Science Signaling, 2009
Activation of TLR4 by the extracellular matrix glycoprotein tenascin-C promotes persistent inflammation in mouse models of rheumatoid arthritis.
openaire   +2 more sources

TLR4 as the Mammalian Endotoxin Sensor

2002
For more than a century, the ability to sense endotoxin (later known also as lipopolysaccharide; LPS) stood as the archetypal innate immune response: even before the phrase 'innate immunity' became popular. Yet the mechanism by which LPS initiated a signal remained unknown.
openaire   +2 more sources

Role of TLR4 in Sepsis

2019
Sepsis, a syndrome of physiologic pathologic and biochemical abnormalities induced by infection, is a major public health concern. The concept of sepsis changed as time goes by. According to the Third International Consensus Definitions for Sepsis and Septic Shock, sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host ...
openaire   +2 more sources

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

Nature, 2009
B. Park, D. Song, Ho Min Kim, Byong-Seok Choi, Hayyoung Lee, Jie-Oh Lee   +5 more
semanticscholar   +1 more source

LPS/TLR4 signal transduction pathway.

Cytokine, 2008
Yong-Chen Lu, W. Yeh, P. Ohashi
semanticscholar   +1 more source

LPS-mediated TLR4 clustering is not dependent on LPS binding to TLR4

Journal of Surgical Research, 2006
Ronald V. Maier, Eileen M. Bulger, Joseph Cuschieri   +2 more
openaire   +2 more sources

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Nature Network Boston, 2007
Stephen R. Clark, Adrienne C. Ma, Samantha A. Tavener, B. McDonald, Z. Goodarzi, M. Kelly, K. Patel, S. Chakrabarti, Erin F. McAvoy, G. Sinclair, Elizabeth Keys, E. Allen-Vercoe, R. Devinney, C. Doig, F. Green, P. Kubes   +15 more
semanticscholar   +1 more source

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

Nature Genetics, 2000
N. Arbour, E. Lorenz, B. Schutte, J. Zabner, J. Kline, Michael P. Jones, K. Frees, J. L. Watt, D. Schwartz   +8 more
semanticscholar   +1 more source