Results 141 to 150 of about 9,070 (169)

Downregulation of Toll-Like Receptor Gene Expression Among Hepatitis B Virus-Positive Human Patients. [PDF]

Cureus
Hussein TH, Al-Yami A, Mtiraoui N, Gharbi J, Ben M'hadheb M.   +4 more
europepmc   +1 more source

Mycobacterial Infection in TLR2 and TLR6 Knockout Mice [PDF]

Microbiology and Immunology, 2003
AbstractTo investigate the role of TLR in the development of murine tuberculosis in vivo, TLR2 and TLR6 knockout (KO) mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne infection apparatus. Both TLR2 and TLR6 KO mice survived until sacrifice at 12 weeks after infection.
Shizuo Akira, Osamu Takeuchi, Hiroyuki Yamada   +2 more
exaly   +3 more sources

A TLR6 polymorphism is associated with increased risk of Legionnaires’ disease [PDF]

Genes and Immunity, 2013
Legionella pneumophila (Lp), the etiologic agent of Legionnaires' disease (LD), is an important cause of community-acquired and nosocomial pneumonia. However, the host immune and genetic determinants of human susceptibility to Lp are poorly understood. Here we show that both TLR6 and TLR1 cooperate with TLR2 to recognize Lp in transfected HEK293 cells.
Annelies Verbon, S J Skerrett, Hawn T R
exaly   +5 more sources

TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides [PDF]

Journal of Biological Chemistry, 2006
Bacterial cell walls contain lipoproteins/peptides, which are strong modulators of the innate immune system. Triacylated lipopeptides are assumed to be recognized by TLR2/TLR1-, whereas diacylated lipopeptides use TLR2/TLR6 heteromers for signaling. Following our initial discovery of TLR6-independent diacylated lipopeptides, we could now characterize ...
Shizuo Akira, Holger Heine, Roland Brock   +2 more
exaly   +4 more sources

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TLR6: A novel member of an expanding Toll-like receptor family

Gene, 1999
Drosophila Toll protein is shown to activate the innate immune system in adult and regulate the dorsoventral patterning in the developing embryo. Recently, five human homologs of Drosophila Toll, designated as Toll-like receptors (TLRs), have been identified and shown to play a role in the innate immune response.
O, Takeuchi, T, Kawai, H, Sanjo, N G, Copeland, D J, Gilbert, N A, Jenkins, K, Takeda, S, Akira   +7 more
openaire   +2 more sources

Porcine TLR2 and TLR6: Identification and Their Involvement in Mycoplasma hyopneumoniae Infection

Journal of Interferon & Cytokine Research, 2003
We successfully cloned and sequenced porcine toll-like receptor (TLR2) and TLR6 cDNA from porcine alveolar macrophages stimulated with 10 microg/ml lipopolysaccharide (LPS). The open reading frames (ORFs) of the porcine TLR2 and TLR6 cDNA were shown to be 2358 and 2391 bp in length and to encode 785 and 796 amino acids, respectively.
Yoshihiro, Muneta, Hirohide, Uenishi, Reiko, Kikuma, Kazuhiro, Yoshihara, Yoshihiro, Shimoji, Ryuji, Yamamoto, Noriyuki, Hamashima, Yuichi, Yokomizo, Yasuyuki, Mori   +8 more
openaire   +2 more sources

Deleterious intestinal inflammation in neonatal mice treated with TLR2/TLR6 agonists

Journal of Leukocyte Biology
Abstract By providing innate immune modulatory stimuli, the early-life immune system can be enhanced to increase resistance to infections. Activation of innate cell surface receptors called pattern recognition receptors by Toll-like receptor (TLR) ligands is one promising approach that can help to control infections as described for ...
Sonia Lamandé, Fabrice Laurent, Catherine Werts   +2 more
exaly   +4 more sources

Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination [PDF]

Gut Pathogens, 2017
Toll-like receptors (TLRs) are the major pattern recognition receptors that mediate sensing of a wide range of microorganisms. TLR2 forms heterodimers with either TLR1 or TLR6, broadening its ligand diversity against pathogens. TLR1, TLR2 and TLR6 have been implicated in the recognition of Candida albicans, an opportunistic fungal pathogen that ...
Didier Le Roy, Daniel Poulain, Samir Jawhara   +2 more
exaly   +7 more sources

Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility

Immunologic Research, 2015
Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products. Ligand binding to TLRs activates the signaling cascade and results in activation of multiple inflammatory genes. Variation in this immune response is under genetic control.
Mamoona, Noreen, Muhammad, Arshad
openaire   +2 more sources

Characteristics of Tlr6 Receptor Expression in Patients with Bronchial Asthma

International Journal of Modern Medicine
The aim of this study was to investigate the features of innate immunity receptor (TLR6) expression in patients with bronchial asthma (BA). The study examined 45 pediatric patients with BA aged 5 to 15 years. The comparison group consisted of 31 children with recurrent obstructive bronchitis (ROB).
Shamsiev F.M., Azizova N.D., Musajanova R.A., Abdullaeva M.K., Karimova M.Kh., Uzakova Sh.B.   +5 more
openaire   +1 more source