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An association between TLR1 and TLR6 gene polymorphism and development of bronchial asthma [PDF]
Russian Pulmonology, 2017 The aim of this study was to analyze an association between TLR1 and TLR6 gene polymorphism and development of bronchial asthma in Russian patients living at the Republic of Bashkortostan. Methods. We investigated DNA samples of unrelated individuals (n =
G. F. Gimalova +5 more
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TLR6: A novel member of an expanding Toll-like receptor family
Gene, 1999Drosophila Toll protein is shown to activate the innate immune system in adult and regulate the dorsoventral patterning in the developing embryo. Recently, five human homologs of Drosophila Toll, designated as Toll-like receptors (TLRs), have been identified and shown to play a role in the innate immune response.
O, Takeuchi +7 more
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Porcine TLR2 and TLR6: Identification and Their Involvement in Mycoplasma hyopneumoniae Infection
Journal of Interferon & Cytokine Research, 2003We successfully cloned and sequenced porcine toll-like receptor (TLR2) and TLR6 cDNA from porcine alveolar macrophages stimulated with 10 microg/ml lipopolysaccharide (LPS). The open reading frames (ORFs) of the porcine TLR2 and TLR6 cDNA were shown to be 2358 and 2391 bp in length and to encode 785 and 796 amino acids, respectively.
Yoshihiro, Muneta +8 more
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Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility
Immunologic Research, 2015Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products. Ligand binding to TLRs activates the signaling cascade and results in activation of multiple inflammatory genes. Variation in this immune response is under genetic control.
Mamoona, Noreen, Muhammad, Arshad
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Characteristics of Tlr6 Receptor Expression in Patients with Bronchial Asthma
International Journal of Modern MedicineThe aim of this study was to investigate the features of innate immunity receptor (TLR6) expression in patients with bronchial asthma (BA). The study examined 45 pediatric patients with BA aged 5 to 15 years. The comparison group consisted of 31 children with recurrent obstructive bronchitis (ROB).
Shamsiev F.M. +5 more
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Single nucleotide polymorphisms and haplotypes of TLR6 gene in Chinese Cantonese population
International Journal of Immunogenetics, 2010SummarySequence polymorphisms in the coding region of Toll‐like receptor 6 gene were investigated in Chinese Cantonese population. By amplifying and sequencing a 2787 bp segment containing the entire coding region of TLR6 gene of 191 individuals in Chinese Cantonese population, a total of seven single nucleotide polymorphisms (SNP) along with their ...
W J, Xiao +3 more
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Involvement of TLR6/1 in rLcrV-mediated immunomodulation of murine peritoneal macrophages in vitro
Molecular Immunology, 2005LcrV of Yersinia pestis is an enigmatic antigenic protein having multiple functions such as effector, translocator and regulator in Type III secretion system. In present study, it is reported that rLcrV causes subversion of macrophage-mediated immune functions.
Rajesh Kumar, Sharma +2 more
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