Results 261 to 270 of about 74,934 (299)

LC3 anchors TLR9 signalling

Nature Reviews Immunology, 2018
TLR9-mediated signalling induces type I IFN production through the direct recruitment of IKKα to a signalling platform anchored by the autophagy protein LC3.
exaly   +3 more sources

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

Nature Immunology, 2004
Eicke Latz, Katherine A Fitzgerald, Brian G Monks   +2 more
exaly   +2 more sources

Clocking on for TLR9

Nature Reviews Immunology, 2012
exaly   +2 more sources

Development of CpG oligodeoxynucleotide TLR9 agonists in anti-cancer therapy

Expert Review of Anticancer Therapy, 2021
Introduction Toll-like receptor-9(TLR9) can recognize the foreign unmethylated CpG DNA, and thus intrigue a strong Th1 response which plays a crucial role in the innate and adaptive immune responses.
Yizhen Jin, Yuxin Zhuang, Xiaowu Dong, Mei Liu   +3 more
semanticscholar   +1 more source

Hydroxychloroquine inhibiting neutrophil extracellular trap formation alleviates hepatic ischemia/reperfusion injury by blocking TLR9 in mice.

Clinical Immunology, 2020
Hepatic ischemia/reperfusion (I/R) injury may arise after partial hepatectomy and liver transplantation. Neutrophil extracellular traps (NETs) were involved in hepatic I/R injury.
Sigong Zhang, Qiuyue Zhang, Furong Wang, Xuehui Guo, Tao Liu, Yang Zhao, Baohong Gu, Hao Chen, Yumin Li   +8 more
semanticscholar   +1 more source

DNA Motifs Suppressing TLR9 Responses

Critical Reviews™ in Immunology, 2006
Immune cells respond to bacterial DNA containing unmethylated CpG motifs via Toll-like receptor 9 (TLR9). Given the apparent role of TLR9 in development of systemic lupus erythematosus (SLE), there is interest in the development of TLR9 inhibitors. TLR9-mediated responses are reported to be inhibited by a confusing variety of different DNA sequences ...
Trieu, Angela, Roberts, Tara L. (R17471), Dunn, Jasmyn A., Sweet, Matthew J., Stacey, Katryn J.   +4 more
openaire   +3 more sources

TLR9-Mediated Recognition of DNA

2008
The mammalian immune system senses pathogens through pattern recognition receptors (PRRs) and responds with activation. The Toll-like receptor (TLR) family that consists of 13 receptors plays a critical role in this process. TLRmediated signaling activates immune cells and leads to an innate immune response with subsequent initiation of an adaptive ...
Thomas, Müller, Svetlana, Hamm, Stefan, Bauer   +2 more
openaire   +2 more sources

TLR9 in Health and Disease

International Reviews of Immunology, 2006
Toll-like receptor 9 (TLR9) is specialized for the recognition of pathogenic nucleic acids. TLR9 is expressed in intracellular compartments where it responds specifically to pathogen DNA. Several factors contribute to the ability of TLR9 to discriminate between self and foreign DNA.
openaire   +2 more sources

Bacterial CpG-DNA Licenses TLR9

2002
The family of Toll-like receptors (TLRs) plays an important role in the innate immune response to pathogens. TLRs sense pathogen associated molecular patterns (PAMP) and lead to the stimulation of immune cells. In man, so far ten members (TLR1-10) have been reported.
S, Bauer, H, Wagner
openaire   +2 more sources

Expression of TLR9 within human glioblastoma

Journal of Neuro-Oncology, 2008
Immunostimulating oligonucleotides containing CpG motifs (CpG-ODN) have shown promising antitumor activity in preclinical glioma models. CpG motifs are specifically recognized by the Toll-like receptor 9 (TLR9), mainly expressed in plasmacytoid dendritic cells (pDCs) and B cells. Expression of TLR9 within human glioma samples has not been investigated.
Yuxia, Meng, Michèle, Kujas, Yannick, Marie, Sophie, Paris, Joëlle, Thillet, Jean-Yves, Delattre, Antoine F, Carpentier   +6 more
openaire   +2 more sources