Results 241 to 250 of about 148,110 (341)

Untangling the TLRs [PDF]

Nature Reviews Immunology, 2002
openaire   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

The emerging role of TLR7-mediated signaling in respiratory viral infections and autoimmune diseases. [PDF]

Cell Mol Life Sci
Wang C, Evangelista JF, Vidal AKN, Islamuddin M, Chen Y, Xu D, Qin X.   +6 more
europepmc   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

A two-step bioconjugation of <i>S. aureus</i> lipoteichoic acid (LTA) affords fluorescent probes that illuminate the interaction between Gram-positive glycolipids and mammalian cell membranes. [PDF]

RSC Chem Biol
Henry J, Nabarro J, Chidwick H, Conrich-Wilks G, Morton-West EG, Crook A, Boucher D, Signoret N, Fascione MA.   +8 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

COVID-19, the disease that changed the world. [PDF]

Med Pharm Rep
Petrovan A, Puiu L, Pop CM.
europepmc   +1 more source

TLR choreography

Journal of Experimental Medicine, 2009
openaire   +2 more sources

Heparan sulfate and glycomimetics: Advances in synthesis and biological applications for post‐stroke neurorepair

Neuroprotection, EarlyView.
ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan, Madeleine J. Smith, Simon F. R. Hinkley, Andrew N. Clarkson   +3 more
wiley   +1 more source

Dental Pulp Stem Cells for the Management of Plaque Biofilm-Associated Infections : A Review. [PDF]

Int Dent J
Aliniay-Sharafshadehi S, Sheykhhasan M, Sharifi K, Ansari-Mohseni A, Yousefi MH, Afkhami H, Mehdipour A, Aghaali M.   +7 more
europepmc   +1 more source