Results 191 to 200 of about 21,015 (212)
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TMAO to the rescue of pathogenic protein variants
Biochimica et Biophysica Acta (BBA) - General Subjects, 2022Trimethylamine N-oxide (TMAO) is a chemical chaperone found in various organisms including humans. Various studies unveiled that it is an excellent protein-stabilizing agent, and induces folding of unstructured proteins. It is also well established that it can counteract the deleterious effects of urea, salt, and hydrostatic pressure on macromolecular ...
Kritika, Kumari +4 more
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Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease
Current Atherosclerosis Reports, 2021The association between plasma Trimethylamine N-Oxide (TMAO), diet and risk for cardiovascular disease (CVD) is still not fully understood. While epidemiologic research shows a causal relationship between plasma TMAO concentrations and CVD risk, the role of dietary precursors in determining plasma concentrations of TMAO and biomarkers for CVD is ...
Minu S. Thomas, Maria Luz Fernandez
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TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies
Journal of Cardiovascular Translational Research, 2021Hypertension is the most prevalent chronic disease and a risk factor for various diseases. Although its mechanisms and therapies are constantly being updated and developed, they are still not fully clarified. In recent years, novel gut microbiota and its metabolites have attracted widespread attention.
Wan-Qin Zhang +9 more
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TMAO: A small molecule of great expectations
Nutrition, 2015Trimethylamine N-oxide (TMAO) is a small organic compound whose concentration in blood increases after ingesting dietary l-carnitine and phosphatidylcholine. Recent clinical studies show a positive correlation between elevated plasma levels of TMAO and an increased risk for major adverse cardiovascular events defined as death, myocardial infarction, or
Marcin, Ufnal +2 more
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The Journal of Physical Chemistry B, 2017
Five molecular models for trimethylamine N-oxide (TMAO) to be used in conjunction with compatible models for liquid water are evaluated by comparison of molecular dynamics (MD) simulation results to experimental data as functions of TMAO molality. The experimental data comprise thermodynamic properties (density, apparent molar volume, and partial molar
Daniel Markthaler +4 more
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Five molecular models for trimethylamine N-oxide (TMAO) to be used in conjunction with compatible models for liquid water are evaluated by comparison of molecular dynamics (MD) simulation results to experimental data as functions of TMAO molality. The experimental data comprise thermodynamic properties (density, apparent molar volume, and partial molar
Daniel Markthaler +4 more
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The Journal of Physical Chemistry B, 2016
Classical molecular dynamics simulation of GB1 peptide (a 16-residue β-hairpin) in different osmotic environments is studied. Urea is used for denaturation of the peptide, and trimethylamine-N-oxide (TMAO) is used to offset the effect of urea. Protein-urea electrostatic interactions are found to play a major role in protein-denaturation.
Gargi, Borgohain, Sandip, Paul
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Classical molecular dynamics simulation of GB1 peptide (a 16-residue β-hairpin) in different osmotic environments is studied. Urea is used for denaturation of the peptide, and trimethylamine-N-oxide (TMAO) is used to offset the effect of urea. Protein-urea electrostatic interactions are found to play a major role in protein-denaturation.
Gargi, Borgohain, Sandip, Paul
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Temperature induced change of TMAO effects on hydrophobic hydration
The Journal of Chemical Physics, 2022The effect of trimethylamine-N-oxide (TMAO) on hydrophobic solvation and hydrophobic interactions of methane has been studied with Molecular Dynamics simulations in the temperature range between 280 and 370 K at 1 bar ambient pressure. We observe a temperature transition in the effect of TMAO on the aqueous solubility of methane.
Angelina Folberth +1 more
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Localization, characterization and partial purification of TMAO-ase
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19821. Formaldehyde (FA) and dimethylamine (DMA) are generated in several species of fish of commercial importance. 2. The present study describes the localization, partial purification and characterization of an enzyme recovered from cod kidney tissue which is responsible for the reduction of trimethylamine oxide (TMAO) to FA and DMA. 3.
T A, Gill, A T, Paulson
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Counteraction ability of TMAO toward different denaturing agents
Biopolymers, 2018AbstractDifferential scanning calorimetry measurements performed on RNase A in aqueous binary solutions containing different concentrations of urea, tetramethylurea, guanidinium chloride, and guanidinium thiocyanate, and in aqueous ternary solutions, containing the same denaturants plus 1 M trimethylamine N‐oxide, TMAO, demonstrate that the latter has ...
Vigorita, Marilisa +4 more
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P27 TMAO : un nouveau marqueur d’athérosclérose ?
Diabetes & Metabolism, 2014Introduction Les microbacteries intestinales produisent a partir de la phosphatidylcholine (lecithine) et de la carnitine, du trimethylamine (TMA), qui est rapidement converti dans le foie en TMA-N oxide (TMAO). A forte concentration, ce metabolite est considere comme un biomarqueur de l’atherosclerose chez l’animal et chez l’homme (Wang et al.
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