Results 111 to 120 of about 4,877 (202)

TMEM16A is associated with Voltage-gated Calcium Channels in mouse retina and its function is disrupted upon mutation of the auxiliary α2δ4 subunit.

Frontiers in Cellular Neuroscience, 2015
Photoreceptors rely upon highly specialized synapses to efficiently transmit signals to multiple postsynaptic targets. Calcium influx in the presynaptic terminal is mediated by voltage-gated calcium channels (VGCC).
Antonella eCaputo, Ilaria ePiano, Gian Carlo eDemontis, Niccolò eBacchi, Simona eCasarosa, Luca eDella Santina, Claudia eGargini   +6 more
doaj   +1 more source

Die Bedeutung des calciumaktivierten Chloridkanals TMEM16A in vaskulären glatten Muskelzellen [PDF]

, 2015
Der arterielle Blutdruck wird durch das Herzzeitvolumen und den peripheren Widerstand des Gefäßsystems bestimmt. Dieser hängt wesentlich vom Tonus kleiner Arteriolen ab, die ihren Durchmesser durch Kontraktion ihrer glatten Muskelzellen verändern können.
Heinze, Christoph
core  

Knockdown of TMEM16A in SW620 cells.

, 2014
A, Western blot analysis of TMEM16A protein expression in SW620 cells that were transfected with shRNA #1 and #2. B, The bar graph summarizes the relative expression level of TMEM16A protein from panel A.
Xuedong Fang (227155), Lili Zhong (679551), Meiyan Sun (679548), Tonghui Ma (549091), Guizhen Zhang (679550), Jinhao Zheng (679553), Yujie Sui (549090), Zhiming Ma (679552), Fei Wu (117860), Weihua Di (679549), Longfei Yang (435484)   +10 more
core   +1 more source

Modulation of TMEM16A-Channel Activity as Ca2+ Activated Cl− Conductance via the Interaction With Actin Cytoskeleton in Murine Portal Vein

Journal of Pharmacological Sciences, 2014
.: TMEM16A is a major component of Ca2+-activated Cl− channel (CaCC) conductance in murine portal vein smooth muscle cells (mPVSMCs). Here, the regulation of CaCC activity by the actin cytoskeleton was examined in mPVSMCs.
Junya Ohshiro, Hisao Yamamura, Yoshiaki Suzuki, Yuji Imaizumi   +3 more
doaj   +1 more source

TMEM16A blocker as vasorelaxant

, 2013
Background and purposeT16A(inh) -A01 is a recently identified inhibitor of the calcium-activated chloride channel TMEM16A. The aim of this study was to test the efficacy of T16A(inh) -A01 for inhibition of calcium-activated chloride channels in vascular smooth muscle and consequent effects on vascular tone.Experimental approachSingle channel and whole ...
Davis, Alison J, Shi, Jian, Pritchard, Harry AT, Chadha, Preet S, Leblanc, Normand, Vasilikostas, Georgios, Yao, Zhen, Verkman, AS, Albert, Anthony P, Greenwood, Iain A   +9 more
openaire   +2 more sources

9‐phenanthrol inhibits TMEM16A channels

The FASEB Journal, 2013
Intravascular pressure stimulates several smooth muscle cell TRP channels, including TRPM4, leading to membrane depolarization and vasoconstriction (the myogenic response). Previous studies using 9‐phenanthrol (9‐phen), a TRPM4 channel inhibitor, suggest that TRPM4 is essential for pressure‐induced depolarization and constriction ...
Sarah Burris, Zachary P. Neeb, Jonathan Jaggar   +2 more
openaire   +1 more source

TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis [PDF]

, 2019
Pancreatic cancer typically spreads rapidly and has poor survival rates. Here, we report that the calcium-activated chloride channel TMEM16A is a biomarker for pancreatic cancer with a poor prognosis. TMEM16A is up-regulated in 75% of cases of pancreatic
Lin, Yu-Hsiu T, Jan, Yuh, Wiita, Arun, Gilchrist, John, Gilchrist, John M, Lin, Yu-Hsiu, Crottès, David, Peters, Christian, Peters, Christian J, Jan, Lily, Wiita, Arun P, Jan, Yuh Nung, Jan, Lily Yeh   +12 more
core   +1 more source

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Frontiers in Pharmacology, 2019
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations.
Kent Miner, Katja Labitzke, Benxian Liu, Paul Wang, Kathryn Henckels, Kevin Gaida, Robin Elliott, Jian Jeffrey Chen, Longbin Liu, Anh Leith, Esther Trueblood, Esther Trueblood, Esther Trueblood, Kelly Hensley, Kelly Hensley, Kelly Hensley, Xing-Zhong Xia, Oliver Homann, Brian Bennett, Mike Fiorino, John Whoriskey, Gang Yu, Sabine Escobar, Min Wong, Teresa L. Born, Alison Budelsky, Mike Comeau, Dirk Smith, Jonathan Phillips, James A. Johnston, Joseph G. McGivern, Kerstin Weikl, David Powers, Karl Kunzelmann, Deanna Mohn, Andreas Hochheimer, John K. Sullivan   +36 more
doaj   +1 more source

CLCA2 does not increase TMEM16A stability or surface occupancy.

, 2018
(A) Immunofluorescence micrographs showing HEK293 cells stably expressing vector (upper row) or CLCA2 (lower row) and probed for transduced TMEM16A or CLCA2.
Aarushi Sharma (5216615), Grace Ramena (2549773), Louis Premkumar (5216612), Yufang Yin (2549770), Randolph C. Elble (502366)   +4 more
core   +1 more source

Immunofluorescence labeling of TMEM16A in CRC cell lines.

, 2014
Cells were grown on coverslips and stained with anti-TMEM16A antibodies. Left column, anti-TMEM16A immunofluorescence (Cy3, red). Middle column, DAPI staining to visualize nuclei.
Xuedong Fang (227155), Lili Zhong (679551), Meiyan Sun (679548), Tonghui Ma (549091), Guizhen Zhang (679550), Jinhao Zheng (679553), Yujie Sui (549090), Zhiming Ma (679552), Fei Wu (117860), Weihua Di (679549), Longfei Yang (435484)   +10 more
core   +1 more source