Results 121 to 130 of about 4,877 (202)

To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN [PDF]

, 2014
PURPOSE: Tumor metastasis is the leading cause of death in patients with cancer. However, the mechanisms that underlie metastatic progression remain unclear.
Bertrand, Carol A, Puthenveedu, Manojkumar A, sano, daisuke, puthenveedu, manojkumar, Shao, Chunbo, duvvuri, umamaheswar, Shao , Chunbo, ha, patrick, Shiwarski, Daniel J, Shiwarski, Daniel, Gaither, Larry, kim, jean, myers, jeffery, Seethala, Raja S, grandis, jennifer, Myers, Jeffery N, Bill, Anke, xiao, dong, bertrand, carol, seethala, raja, Gaither, L Alex   +20 more
core   +1 more source

Data_Sheet_1_Control of Ion Transport by Tmem16a Expressed in Murine Intestine.PDF

, 2019
Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann (80303), Inês Cabrita (7461878), Podchanart Wanitchakool (5821628), Raquel Centeio (7461875), Rainer Schreiber (80302), Kazi Mirajul Hoque (822762), Roberta Benedetto (7461881), Tultul Saha (822761)   +7 more
core   +1 more source

TMEM16A Potentiation: Possible Drawbacks

American Journal of Respiratory and Critical Care Medicine, 2020
Andrea Olschewski, Chandran Nagaraj, Diana Zabini, Bence M. Nagy, Grazyna Kwapiszewska, Horst Olschewski   +5 more
openaire   +2 more sources

Pharmacological properties of native CaCCs and TMEM16A [PDF]

Channels, 2014
Kenton M, Sanders, Kate, O'Driscoll, Normand, Leblanc   +2 more
openaire   +2 more sources

Olfactory sensory neurons in the developing olfactory epithelium of TMEM16A^-/- and TMEM16A^+/+ mice.

, 2015
Mature olfactory sensory neurons express the olfactory marker protein (OMP). Confocal images of coronal sections of the olfactory epithelium at E14.5, E16.5, E18.5 and P4 from TMEM16A-/- (A, C, E, G) or TMEM16A+/+ (B, D, F, H) mice.
Devendra Kumar Maurya (753367), Anna Menini (266689), Nicoletta Pedemonte (383764), Tiago Henriques (753368), Jason R. Rock (247452), Monica Marini (753369), Brian D. Harfe (148989), Luis J. V. Galietta (753370)   +7 more
core   +1 more source

The Tmem16a chloride channel is required for mucin maturation after secretion from goblet-like cells in the Xenopus tropicalis tadpole skin

Scientific Reports
The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms.
Eamon Dubaissi, Emma N. Hilton, Sarah Lilley, Richard Collins, Charlotte Holt, Peter March, Henry Danahay, Martin Gosling, Richard K Grencis, Ian S Roberts, David J Thornton   +10 more
doaj   +1 more source

Control of TMEM16A by INO‐4995 and other inositolphosphates

, 2013
Background And Purpose Ca2+-dependent Cl- secretion (CaCC) in airways and other tissues is due to activation of the Cl- channel TMEM16A (anoctamin 1).
Fragata, José I, Tian, Yuemin, Kongsuphol, Patthara, Uliyakina, Inna, Faria, Diana, Wanitchakool, Podchanart, Kunzelmann, Karl, Traynor‐Kaplan, Alexis E, Schreiber, Rainer, Sousa, Marisa, Palma, Marta, Amaral, Margarida D   +11 more
core   +1 more source

TMEM16A knockdown induced a decrease in proliferation of SW620 cells.

, 2014
A, The growth of SW620 cells was inhibited by TMEM16A shRNA #1 and #2 compared to the control group (Mean ± SD; n = 3 ...
Xuedong Fang (227155), Lili Zhong (679551), Meiyan Sun (679548), Tonghui Ma (549091), Guizhen Zhang (679550), Jinhao Zheng (679553), Yujie Sui (549090), Zhiming Ma (679552), Fei Wu (117860), Weihua Di (679549), Longfei Yang (435484)   +10 more
core   +1 more source

TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression

, 2012
Frequent gene amplification of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its involvement in human tumorigenesis has not been previously studied.
Egloff, Ann Marie, Edinger, Robert S., Harfe, Brian D., Shiwarski, Daniel J., Kunzelmann, Karl, Schreiber, Rainer, Chen, Xing, Rock, Jason R., Seethala, Raja S., Gollin, Susanne M., Bertrand, Carol, Huang, Xin, Henson, Brian J., Lui, Vivian W., Duvvuri, Umamaheswar, Grandis, Jennifer R., Xiao, Dong   +16 more
core   +1 more source

Intestinal epithelial ion channel TMEM16A deficiency impairs enteroendocrine cell differentiation and epithelial homeostasis and enhances anxiety-like behavior in mice

陆军军医大学学报
Objective Transmembrane member 16A (TMEM16A) is involved in intestinal epithelial ion transport and secretory homeostasis, but its effects on enteroendocrine cell (EEC) function and gut-brain axis-related behaviors remain unclear.
Wang Hao, Sun Meiyan
doaj   +1 more source