Results 51 to 60 of about 4,623 (196)
Arctigenin Attenuates Vascular Inflammation Induced by High Salt through TMEM16A/ESM1/VCAM-1 Pathway
Biomedicines, 2022 Salt-sensitive hypertension is closely related to inflammation, but the mechanism is barely known. Transmembrane member 16A (TMEM16A) is the Ca2+-activated chloride channel in epithelial cells, smooth muscle cells, and sensory neurons.
Mengying Zeng +5 more
doaj +1 more source
HIF-Regulated Pannexin-1 Channel Drives Luminal ATP Accumulation in Kidney Cysts. [PDF]
FASEB JAutosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Skoczynski K +10 more
europepmc +2 more sources
Expression of TMEM16A and SLC4A4 in Human Pancreatic Islets [PDF]
Cellular Physiology and Biochemistry, 2012 Stimulation of insulin release by D-glucose is accompanied by Cl(-) and HCO(3)(-) efflux from pancreatic islet cells. The efflux of these anions may involve volume-regulated anion channels, including possibly TMEM16A, and the Na(+)-HCO(3)(-)-cotransporter SLC4A4.
Hanzu, Felicia A +7 more
openaire +3 more sources
Acta Pharmaceutica Sinica B, 2021 Vascular smooth muscle cell (VSMC) migration plays a critical role in the pathogenesis of many cardiovascular diseases. We recently showed that TMEM16A is involved in hypertension-induced cerebrovascular remodeling.
Huaqing Zheng +10 more
doaj +1 more source
ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]
, 2009 Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Rainer Schreiber +13 more
core +2 more sources
Expression of TMEM16A in various nasal glands of TMEM16A-/- and TMEM16A+/+ littermate mice. [PDF]
, 2015 Expression of TMEM16A and aquaporin 5 in the Bowman’s gland (BG), nasal septal gland (NSG) and lateral nasal gland (LNG) of TMEM16A-/- and TMEM16A+/+ littermate mice.
Devendra Kumar Maurya (753367) +7 more
core +1 more source
Expression of TMEM16A and ACIII in the olfactory epithelium of TMEM16A-/- and TMEM16A+/+ littermate mice. [PDF]
, 2015 Confocal images of coronal sections of the olfactory epithelium from a region near the transition zone with the respiratory epithelium at E14.5, E16.5, E18.5 and P4.
Devendra Kumar Maurya (753367) +7 more
core +1 more source
Frontiers in Physiology, 2022 Background: Cardiac hypertrophy (CH) occurs with an increase in myocardium mass as an adaptive compensation to increased stress. Prolonged CH causes decompensated heart failure (HF).
Yaofang Zhang +4 more
doaj +1 more source
ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC) [PDF]
Pflügers Archiv - European Journal of Physiology, 2014 Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca(2+)-activated Cl(-) channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in the recent years, its pathophysiological function has only been poorly understood.
Sauter, Daniel Rafael Peter +4 more
openaire +4 more sources
CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A [PDF]
, 2021 TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are associated with inflammatory airway disease and goblet cell metaplasia.
Raquel Centeio +7 more
core +1 more source