Results 51 to 60 of about 3,924 (173)

Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation

Cells, 2020
Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher expression levels
Madalena C. Pinto, Rainer Schreiber, Joana Lerias, Jiraporn Ousingsawat, Aires Duarte, Margarida Amaral, Karl Kunzelmann   +6 more
doaj   +1 more source

TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium

Frontiers in Physiology, 2023
Cl− channels such as the Ca2+ activated Cl− channel TMEM16A and the Cl− permeable phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−]i), which could act as an intracellular signal.
Raquel Centeio, Inês Cabrita, Rainer Schreiber, Karl Kunzelmann   +3 more
doaj   +1 more source

ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC) [PDF]

Pflügers Archiv - European Journal of Physiology, 2014
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca(2+)-activated Cl(-) channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in the recent years, its pathophysiological function has only been poorly understood.
Sauter, Daniel Rafael Peter, Novak, Ivana, Pedersen, Stine Helene Falsig, Larsen, Erik Hviid, Hoffmann, Else Kay   +4 more
openaire   +4 more sources

Hepatocyte TMEM16A Deletion Retards NAFLD Progression by Ameliorating Hepatic Glucose Metabolic Disorder

Advanced Science, 2020
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease, and the mechanisms underpinning its pathogenesis have not been completely established.
Jia‐Wei Guo, Xiu Liu, Ting‐Ting Zhang, Xiao‐Chun Lin, Yu Hong, Jie Yu, Qin‐Yan Wu, Fei‐Ran Zhang, Qian‐Qian Wu, Jin‐Yan Shang, Xiao‐Fei Lv, Jing‐Song Ou, Jia‐Guo Zhou, Rui‐Ping Pang, Bao‐Dong Tang, Si‐Jia Liang   +15 more
doaj   +1 more source

Gating the pore of the calcium-activated chloride channel TMEM16A [PDF]

Nature Communications, 2021
AbstractThe binding of cytoplasmic Ca2+ to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck of an hourglass-shaped pore. By combining mutagenesis, electrophysiology, and cryo-electron microscopy, we identified three hydrophobic residues at the ...
Lam, Andy K M, Rheinberger, Jan, Paulino, Cristina, Dutzler, Raimund   +3 more
openaire   +4 more sources

Intestinal TMEM16A control luminal chloride secretion in a NHERF1 dependent manner

Biochemistry and Biophysics Reports, 2021
TMEM16A (Transmembrane protein 16A or Anoctamin1) is a calcium-activated chloride channel.(CaCC),that exerts critical roles in epithelial secretion. However, its localization, function, and regulation in intestinal chloride (Cl−) secretion remain obscure.
Tultul Saha, Joydeep Aoun, Mikio Hayashi, Sheikh Irshad Ali, Paramita Sarkar, Prasanta Kumar Bag, Normand Leblanc, Nadia Ameen, Owen M. Woodward, Kazi Mirajul Hoque   +9 more
doaj   +1 more source

Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl− channels

Journal of Pharmacological Sciences, 2021
The blood–brain barrier (BBB) is mainly formed by brain capillary endothelial cells (BCECs) and is exposed to hypoxic environments under pathological conditions. The effects of hypoxia on the expression and activity of Ca2+-activated Cl− (ClCa) channels,
Takahisa Suzuki, Yoshiaki Suzuki, Kiyofumi Asai, Yuji Imaizumi, Hisao Yamamura   +4 more
doaj   +1 more source

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

Role of ANO1‐Expressing PDGFRα+ Smooth Muscle Cells in Generating Spontaneous Phasic Contractions of the Rodent Epididymis

Andrology, EarlyView.
ABSTRACT Background Spontaneous phasic contractions (SPCs) in the epididymal duct play an important role in transport and maturation of sperm. In proximal cauda of the rat epididymis, platelet‐derived growth factor receptor α (PDGFRα)‐positive smooth muscle cells (SMCs) generate ANO1 Ca2+‐activated chloride channels (CaCCs)‐dependent spontaneous ...
Wataru Kudo, Hiromichi Takano, Toshiya Izuchi, Retsu Mitsui, Kyoko Miwa‐Nishimura, Hikaru Hashitani   +5 more
wiley   +1 more source

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing [PDF]

Journal of Biological Chemistry, 2009
Expression of TMEM16A protein is associated with the activity of Ca(2+)-activated Cl(-) channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the generation of multiple isoforms. We have determined the pattern of splicing and assessed the functional properties of the corresponding TMEM16A variants.
Ferrera, Loretta, Caputo, Antonella, Ubby, Ifeoma, Bussani, Erica, Zegarra-Moran, Olga, Ravazzolo, Roberto, Pagani, Franco, Galietta, Luis J. V.   +7 more
openaire   +4 more sources