Results 41 to 50 of about 3,924 (173)
Expression of TMEM16A and SLC4A4 in Human Pancreatic Islets [PDF]
Cellular Physiology and Biochemistry, 2012 Stimulation of insulin release by D-glucose is accompanied by Cl(-) and HCO(3)(-) efflux from pancreatic islet cells. The efflux of these anions may involve volume-regulated anion channels, including possibly TMEM16A, and the Na(+)-HCO(3)(-)-cotransporter SLC4A4.
Hanzu, Felicia A +7 more
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Journal of Advanced Research, 2020 TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown.
Qinghua Wang +13 more
doaj +1 more source
TMEM16A chloride channel does not drive mucus production
Life Science Alliance, 2019 Despite being essential for airway hydration, TMEM16A is not required for mucus (MUC5AC) production. Cell proliferation is the main driver for TMEM16A up-regulation during inflammation.
Filipa B Simões +7 more
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Epithelial Chloride Transport by CFTR Requires TMEM16A [PDF]
Scientific Reports, 2017 AbstractCystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory chloride/bicarbonate channel in airways and intestine that is activated through ATP binding and phosphorylation by protein kinase A, but fails to operate in cystic fibrosis (CF).
Roberta Benedetto +8 more
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Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
doaj +1 more source
TMEM16A alternative splicing coordination in breast cancer [PDF]
Molecular Cancer, 2013 Abstract Background TMEM16A, also known as Anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. The role of TMEM16A in cancer is not completely understood and no data are available regarding the potential tumorigenic properties of the multiple isoforms generated by ...
Ubby, Ifeoma +7 more
openaire +3 more sources
Control of Ion Transport by Tmem16a Expressed in Murine Intestine
Frontiers in Physiology, 2019 Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann +8 more
doaj +1 more source
TMEM16A as a potential treatment target for head and neck cancer
Journal of Experimental & Clinical Cancer Research, 2022 Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized Ca2+-activated Cl- channel. Its gene has been mapped to an area on chromosome 11q13, which is amplified in head and neck squamous cell carcinoma (HNSCC).
Kohei Okuyama, Souichi Yanamoto
doaj +1 more source
Frontiers in Pharmacology, 2021 Background: Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed ...
Shuai Guo +9 more
doaj +1 more source
TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke
Frontiers in Cellular Neuroscience, 2019 The inflammatory response plays a pivotal role in Blood–Brain Barrier (BBB) destruction following ischemic brain injury. Enhanced leukocyte adhesion to vascular endothelial cells is an essential event in the inflammatory process.
Pin-yi Liu +17 more
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