Results 21 to 30 of about 3,924 (173)

Identification of novel TMEM16A blockers through integrated virtual screening, molecular dynamics, and experimental studies [PDF]

Scientific Reports
The calcium-activated chloride channel TMEM16A is a promising drug target for treating hypertension, secretory diarrheas, and various cancers, including head and neck cancer. Despite its potential, no FDA-approved drugs have provided the structural basis
Mattanun Sangkhawasi, Wichuda Pitaktrakul, Rungtiwa Khumjiang, Yasuteru Shigeta, Chatchai Muanprasat, Kowit Hengphasatporn, Thanyada Rungrotmongkol   +6 more
doaj   +2 more sources

Ca2+-activated Cl− channel TMEM16A inhibition by cholesterol promotes angiogenesis in endothelial cells

Journal of Advanced Research, 2021
Introduction: Ca2+-activated Cl− channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension.
Ke Ma, Sitong Liu, Hongyue Liang, Guan Wang, Tianyu Wang, Shuya Luo, Kuan Gao, Hui Wang, Mei Liu, Lichuan Bai, Qinghuan Xiao   +10 more
doaj   +1 more source

Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells

Membranes, 2021
Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent ...
Khaoula Talbi, Jiraporn Ousingsawat, Raquel Centeio, Rainer Schreiber, Karl Kunzelmann   +4 more
doaj   +1 more source

Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis

Cell Death and Disease, 2022
Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca2+-activated chloride channel, has been implicated in a variety of ...
Jiawei Guo, Zihao Song, Jie Yu, Chengyi Li, Chenchen Jin, Wei Duan, Xiu Liu, Yingying Liu, Shuai Huang, Yonghua Tuo, Fei Pei, Zhengyang Jian, Pengyu Zhou, Shaoyi Zheng, Zhaowei Zou, Feng Zhang, Quan Gong, Sijia Liang   +17 more
doaj   +1 more source

Activation of TMEM16A Ca2+-activated Cl− channels by ROCK1/moesin promotes breast cancer metastasis

Journal of Advanced Research, 2021
Introduction: Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis.
Shuya Luo, Hui Wang, Lichuan Bai, Yiwen Chen, Si Chen, Kuan Gao, Huijie Wang, Shuwei Wu, Hanbin Song, Ke Ma, Mei Liu, Fan Yao, Yue Fang, Qinghuan Xiao   +13 more
doaj   +1 more source

Expression of TMEM16A in Colorectal Cancer and Its Correlation With Clinical and Pathological Parameters

Frontiers in Oncology, 2021
TMEM16A is a recently identified calcium-activated chloride channel (CaCC) and its overexpression contributes to tumorigenesis and progression in several human malignancies.
Hongxia Li, Qiwei Yang, Sibo Huo, Sibo Huo, Zhenwu Du, Zhenwu Du, Fei Wu, Haiyue Zhao, Shifan Chen, Longfei Yang, Zhiming Ma, Yujie Sui   +11 more
doaj   +1 more source

Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f

Gastro Hep Advances, 2022
Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber, Ines Cabrita, Karl Kunzelmann   +2 more
doaj   +1 more source

The pharmacology of the TMEM16A channel: therapeutic opportunities

Trends in Pharmacological Sciences, 2022
The TMEM16A Ca2+-gated Cl- channel is involved in a variety of vital physiological functions and may be targeted pharmacologically for therapeutic benefit in diseases such as hypertension, stroke, and cystic fibrosis (CF). The determination of the TMEM16A structure and high-throughput screening efforts, alongside ex vivo and in vivo animal studies and ...
Rumaitha Al-Hosni, Zeki Ilkan, Emilio Agostinelli, Paolo Tammaro   +3 more
openaire   +2 more sources

Electrophysiological Characterization of TMEM16A [PDF]

Biophysical Journal, 2015
Sweating is an essential physiological process to regulate body temperature in humans and various disorders are associated with dysregulated sweat formation.Primary sweat secretion in human eccrine sweat glands is initiated by Ca2+-activated Cl- channels (CaCC).
Bruggemann, Andrea, Rapedius, Markus, Götze, Tom, Haarmann, Claudia, Rinke, Ilka, Vogel, Marius, Stengel, Timo, Stiehler, Johannes, George, Michael, Fertig, Niels, Ertongur-Fauth, Torsten   +10 more
openaire   +1 more source

TMEM16A inhibition suppresses melanoma metastasis. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Zhou N, Pei C, Lu X, Shi P, Wu S, Chen H.   +5 more
europepmc   +3 more sources