Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice. [PDF]
PLoS ONE, 2015 TMEM16A/ANO1 is a calcium-activated chloride channel expressed in several types of epithelia and involved in various physiological processes, including proliferation and development.
Devendra Kumar Maurya +7 more
doaj +8 more sources
TMEM16A channel signalling microdomains in the regulation of vascular function. [PDF]
J PhysiolAbstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Araujo F, Sonkusare SK.
europepmc +2 more sources
Ca<sup>2+</sup>-Activated Cl<sup>-</sup> Channels: Do Bestrophins and TMEM16A Interact? [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Aalkjær C +4 more
europepmc +2 more sources
The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin
Frontiers in Pharmacology, 2021 The transmembrane 16 (TMEM16) family contains 10 subtypes, and the function of each protein is different. TMEM16A is a calcium-activated chloride channel involved in physiological and pathological situations.
Masataka Sunagawa, Mami Kato
exaly +3 more sources
Renin-Angiotensin Signaling and Vascular Function: Insights into Health and Disease. [PDF]
Acta Physiol (Oxf)ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Bertoldi G, Sonkusare SK.
europepmc +2 more sources
Intracellular TMEM16A is necessary for myogenesis of skeletal muscle
iScience, 2022 Summary: Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and controls chloride influx in various type of cells. We here showed an intracellular localization pattern of TMEM16A molecules.
Wen Yuan +14 more
doaj +3 more sources
The Prognostic Value and Mechanisms of TMEM16A in Human Cancer [PDF]
Frontiers in Molecular Biosciences, 2021 As a calcium ion-dependent chloride channel transmembrane protein 16A (TMEM16A) locates on the cell membrane. Numerous research results have shown that TMEM16A is abnormally expressed in many cancers.
Wenjian Chen +11 more
doaj +3 more sources
Molecular Mechanisms of Electric Signals Generated at Corneal Wounds. [PDF]
FASEB JCorneal injury triggers cell signaling (including calcium waves) leading to ion channel up‐regulation, increased ion pumping, and enhanced wound electric signals which stimulate wound healing. ABSTRACT Over 150 years ago, it was demonstrated that wounds produce electric fields and currents.
Reid B, Luxardi G, Zhao M.
europepmc +2 more sources
HIF-Regulated Pannexin-1 Channel Drives Luminal ATP Accumulation in Kidney Cysts. [PDF]
FASEB JAutosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Skoczynski K +10 more
europepmc +2 more sources
TMEM16A in Cystic Fibrosis: Activating or Inhibiting? [PDF]
Frontiers in Pharmacology, 2019 The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann +8 more
doaj +4 more sources