Results 11 to 20 of about 4,623 (196)
Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice. [PDF]
PLoS ONE, 2015 TMEM16A/ANO1 is a calcium-activated chloride channel expressed in several types of epithelia and involved in various physiological processes, including proliferation and development.
Devendra Kumar Maurya +7 more
doaj +10 more sources
TMEM16A in Cystic Fibrosis: Activating or Inhibiting? [PDF]
Frontiers in Pharmacology, 2019 The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann +8 more
doaj +6 more sources
Cell Death and Disease, 2022 Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca2+-activated chloride channel, has been implicated in a variety of ...
Jiawei Guo +17 more
doaj +2 more sources
Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells [PDF]
Membranes, 2021 Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent ...
Khaoula Talbi +4 more
doaj +2 more sources
Epithelial chloride transport by CFTR requires TMEM16A [PDF]
Scientific Reports, 2017 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory chloride/bicarbonate channel in airways and intestine that is activated through ATP binding and phosphorylation by protein kinase A, but fails to operate in cystic fibrosis (CF).
Michael J. Holtzman +19 more
core +5 more sources
Control of Ion Transport by Tmem16a Expressed in Murine Intestine [PDF]
Frontiers in Physiology, 2019 Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann +8 more
doaj +2 more sources
Intracellular TMEM16A is necessary for myogenesis of skeletal muscle
iScience, 2022 Summary: Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and controls chloride influx in various type of cells. We here showed an intracellular localization pattern of TMEM16A molecules.
Wen Yuan +14 more
doaj +3 more sources
Functional expression of TMEM16A in taste bud cells [PDF]
The Journal of Physiology, 2021 Key points: Taste transduction occurs in taste buds in the tongue epithelium. The Ca2+-activated Cl– channels TMEM16A and TMEM16B play relevant physiological roles in several sensory systems. Here, we report that TMEM16A, but not TMEM16B, is expressed in
Pifferi S. +4 more
core +5 more sources
Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
doaj +2 more sources
The Prognostic Value and Mechanisms of TMEM16A in Human Cancer [PDF]
Frontiers in Molecular Biosciences, 2021 As a calcium ion-dependent chloride channel transmembrane protein 16A (TMEM16A) locates on the cell membrane. Numerous research results have shown that TMEM16A is abnormally expressed in many cancers.
Wenjian Chen +11 more
doaj +3 more sources