Results 21 to 30 of about 4,623 (196)
PLoS ONE, 2015 TMEM16A, a calcium-activated chloride channel (CaCC), is highly amplified and expressed in human cancers and is involved in the growth and metastasis of some malignancies. Inhibition of TMEM16A represents a novel pharmaceutical approach for the treatment
Yujie Sui +11 more
doaj +2 more sources
TMEM16A alternative splicing coordination in breast cancer [PDF]
Molecular Cancer, 2013 BACKGROUND: TMEM16A, also known as Anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. The role of TMEM16A in cancer is not completely understood and no data are available regarding the potential tumorigenic ...
Luis Galietta +23 more
core +5 more sources
Reduced Expression of TMEM16A Impairs Nitric Oxide-Dependent Cl− Transport in Retinal Amacrine Cells [PDF]
Frontiers in Cellular Neuroscience, 2022 Postsynaptic cytosolic Cl− concentration determines whether GABAergic and glycinergic synapses are inhibitory or excitatory. We have shown that nitric oxide (NO) initiates the release of Cl− from acidic internal stores into the cytosol of retinal ...
Tyler Christopher Rodriguez +3 more
doaj +2 more sources
Intermolecular interactions in the TMEM16A dimer controlling channel activity [PDF]
Scientific Reports, 2016 TMEM16A and TMEM16B are plasma membrane proteins with Ca2+-dependent Cl- channel function. By replacing the carboxy-terminus of TMEM16A with the equivalent region of TMEM16B, we obtained channels with potentiation of channel activity.
Gianotti A. +9 more
core +6 more sources
TMEM16A (ANO1) as a therapeutic target in cystic fibrosis
Current Opinion in Pharmacology, 2022 Cystic fibrosis (CF) is a multi-organ genetic disease caused by loss of function of CFTR, a cAMP-regulated chloride channel expressed in epithelial cells.
Galietta, L
core +4 more sources
The role and regulation of TMEM16A in the vascular system
, 2020 TMEM16A is a Ca2+-activated Cl- channel (CaCC) encoded by the TMEM16A gene, expressed in vascular smooth muscle cells (VSMCs). TMEM16A has a proposed role in depolarising the membrane potential (Vm) in response to activation of the Gq-protein coupled ...
Acheson, Kathryn
core +3 more sources
TMEM16A as a potential treatment target for head and neck cancer
Journal of Experimental & Clinical Cancer Research, 2022 Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized Ca2+-activated Cl- channel. Its gene has been mapped to an area on chromosome 11q13, which is amplified in head and neck squamous cell carcinoma (HNSCC).
Kohei Okuyama, Souichi Yanamoto
doaj +2 more sources
Regulation of TMEM16A altrenatice splincing
, 2012 TMEM16A/Anoctamin1 is a novel calcium-‐activated chloride channel involved in neuronal and cardiac excitation, vascular tone, pain perception and olfactory and sensory signal transduction and GI tract motility.
Ubby, Ifeoma
core +2 more sources
Identification of novel TMEM16A blockers through integrated virtual screening, molecular dynamics, and experimental studies [PDF]
Scientific ReportsThe calcium-activated chloride channel TMEM16A is a promising drug target for treating hypertension, secretory diarrheas, and various cancers, including head and neck cancer. Despite its potential, no FDA-approved drugs have provided the structural basis
Mattanun Sangkhawasi +6 more
doaj +2 more sources
Frontiers in Pharmacology, 2019 There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations.
Kelly Hensley +2 more
exaly +3 more sources